Posthepatectomy hepatitis shortens tumor-free intervals in hepatitis C virus-associated hepatocellular carcinoma patients

  • Authors:
    • Susumu Kobayashi
    • Kotaro Iwasaki
    • Takehide Asano
    • Takenori Ochiai
  • View Affiliations

  • Published online on: December 1, 2002     https://doi.org/10.3892/ijmm.10.6.749
  • Pages: 749-753
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Abstract

In hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC), serum alanine aminotransferase (ALT) is frequently sustained on a high level after hepatectomy, with the formation of recurrent HCC tumors during follow-up periods. We investigated whether or not postoperative serum ALT level affects the interval before recurrence in hepatitis C virus-associated HCC. The subjects studied were 50 hepatectomized HCC patients who were HCV-Ab(+), and underwent a curable surgery in our Hospital from June 1990 to December 1999. We assessed the significance of the postoperative serum ALT level affecting tumor-free survival rates, as compared with other clinicopathological parameters, using univariate and multivariate Cox proportional hazard analysis. Thereafter, tumor-free and overall survival rates after hepatectomy were compared between high and low ALT groups, using Kaplan-Meier plotting and a log-rank test. The factor of ALT levels (a high or low ALT group) was most strongly associated with a tumor-free survival rate. Both tumor-free and overall survival rates were significantly poorer in the high ALT group than in the low ALT group among HCV-associated HCC cases (p<0.05). The results in this study suggest that postoperative hepatitis, which is indicated by sustained high ALT levels, may shorten the interval before recurrence in HCV-associated HCC. We should take care to control postoperative hepatitis to improve the prognoses of HCV-associated HCC cases.

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December 2002
Volume 10 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kobayashi S, Iwasaki K, Asano T and Ochiai T: Posthepatectomy hepatitis shortens tumor-free intervals in hepatitis C virus-associated hepatocellular carcinoma patients. Int J Mol Med 10: 749-753, 2002
APA
Kobayashi, S., Iwasaki, K., Asano, T., & Ochiai, T. (2002). Posthepatectomy hepatitis shortens tumor-free intervals in hepatitis C virus-associated hepatocellular carcinoma patients. International Journal of Molecular Medicine, 10, 749-753. https://doi.org/10.3892/ijmm.10.6.749
MLA
Kobayashi, S., Iwasaki, K., Asano, T., Ochiai, T."Posthepatectomy hepatitis shortens tumor-free intervals in hepatitis C virus-associated hepatocellular carcinoma patients". International Journal of Molecular Medicine 10.6 (2002): 749-753.
Chicago
Kobayashi, S., Iwasaki, K., Asano, T., Ochiai, T."Posthepatectomy hepatitis shortens tumor-free intervals in hepatitis C virus-associated hepatocellular carcinoma patients". International Journal of Molecular Medicine 10, no. 6 (2002): 749-753. https://doi.org/10.3892/ijmm.10.6.749