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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2002 Volume 10 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2002 Volume 10 Issue 6

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Article

Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model

  • Authors:
    • Ilana Teruszkin Balassiano
    • Sheila Alves de Paulo
    • Nathalie Henriques Silva
    • Maulori Curié Cabral
    • Daniel Gibaldi
    • Marcelo Bozza
    • Clovis Orlando da Fonseca
    • Maria Da Glória Da Costa Carvalho

  • View Affiliations / Copyright

    Affiliations: Instituto de Biofisica Carlos Chagas Filho, Laboratorio de Controle da Expressao Genica, Universidade Federal do Rio de Janeiro, Centro de Ciencias da Saude, Rio de Janeiro, Brazil
  • Pages: 785-788
    |
    Published online on: December 1, 2002
       https://doi.org/10.3892/ijmm.10.6.785
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Abstract

The search for new chemotherapeutic drugs has increased, especially for those that have a natural origin. The monoterpene perillyl alcohol (POH) has been shown to exert chemopreventive activity in mammary, liver, and lung tumor models. It has also been used to treat a variety of rodent cancers, including pancreatic and breast carcinomas. In vitro data suggest that it may be effective against neuroblastomas and leukemias. This work evaluates the effects of the treatment of murine glial C6 cells with perillyl alcohol. In vitro, our studies have indicated that POH inhibits proliferation of the C6 glial cell line. POH was logarithmically diluted in concentrations of 30% through 0.0003% and showed inhibition cell proliferation of 78.36% in concentration of 30%; 69.87% in concentration of 3%; and 67.04% in concentration of 0.03%. In addition, the anti-metastatic activity of POH against these cells was evaluated using chick embryos as an in vivo model. The experiments have shown anti-metastatic activity of POH when the C6 murine glial cells were exposed to a concentration of 0.3 to 0.003% POH for 2 h, prior to its inoculation in chick embryo chorioallantoic membrane model. This phenomenon shows the possible role of POH as an in vivo anti-metastatic drug.

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Copy and paste a formatted citation
Spandidos Publications style
Teruszkin Balassiano I, Alves de Paulo S, Henriques Silva N, Curié Cabral M, Gibaldi D, Bozza M, Orlando da Fonseca C and Da Glória Da Costa Carvalho M: Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. Int J Mol Med 10: 785-788, 2002.
APA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M. ... Da Glória Da Costa Carvalho, M. (2002). Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. International Journal of Molecular Medicine, 10, 785-788. https://doi.org/10.3892/ijmm.10.6.785
MLA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10.6 (2002): 785-788.
Chicago
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10, no. 6 (2002): 785-788. https://doi.org/10.3892/ijmm.10.6.785
Copy and paste a formatted citation
x
Spandidos Publications style
Teruszkin Balassiano I, Alves de Paulo S, Henriques Silva N, Curié Cabral M, Gibaldi D, Bozza M, Orlando da Fonseca C and Da Glória Da Costa Carvalho M: Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. Int J Mol Med 10: 785-788, 2002.
APA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M. ... Da Glória Da Costa Carvalho, M. (2002). Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. International Journal of Molecular Medicine, 10, 785-788. https://doi.org/10.3892/ijmm.10.6.785
MLA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10.6 (2002): 785-788.
Chicago
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10, no. 6 (2002): 785-788. https://doi.org/10.3892/ijmm.10.6.785
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