Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model

  • Authors:
    • Ilana Teruszkin Balassiano
    • Sheila Alves de Paulo
    • Nathalie Henriques Silva
    • Maulori Curié Cabral
    • Daniel Gibaldi
    • Marcelo Bozza
    • Clovis Orlando da Fonseca
    • Maria Da Glória Da Costa Carvalho
  • View Affiliations

  • Published online on: December 1, 2002     https://doi.org/10.3892/ijmm.10.6.785
  • Pages: 785-788
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The search for new chemotherapeutic drugs has increased, especially for those that have a natural origin. The monoterpene perillyl alcohol (POH) has been shown to exert chemopreventive activity in mammary, liver, and lung tumor models. It has also been used to treat a variety of rodent cancers, including pancreatic and breast carcinomas. In vitro data suggest that it may be effective against neuroblastomas and leukemias. This work evaluates the effects of the treatment of murine glial C6 cells with perillyl alcohol. In vitro, our studies have indicated that POH inhibits proliferation of the C6 glial cell line. POH was logarithmically diluted in concentrations of 30% through 0.0003% and showed inhibition cell proliferation of 78.36% in concentration of 30%; 69.87% in concentration of 3%; and 67.04% in concentration of 0.03%. In addition, the anti-metastatic activity of POH against these cells was evaluated using chick embryos as an in vivo model. The experiments have shown anti-metastatic activity of POH when the C6 murine glial cells were exposed to a concentration of 0.3 to 0.003% POH for 2 h, prior to its inoculation in chick embryo chorioallantoic membrane model. This phenomenon shows the possible role of POH as an in vivo anti-metastatic drug.

Related Articles

Journal Cover

December 2002
Volume 10 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Teruszkin Balassiano I, Alves de Paulo S, Henriques Silva N, Curié Cabral M, Gibaldi D, Bozza M, Orlando da Fonseca C and Da Glória Da Costa Carvalho M: Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. Int J Mol Med 10: 785-788, 2002
APA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M. ... Da Glória Da Costa Carvalho, M. (2002). Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model. International Journal of Molecular Medicine, 10, 785-788. https://doi.org/10.3892/ijmm.10.6.785
MLA
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10.6 (2002): 785-788.
Chicago
Teruszkin Balassiano, I., Alves de Paulo, S., Henriques Silva, N., Curié Cabral, M., Gibaldi, D., Bozza, M., Orlando da Fonseca, C., Da Glória Da Costa Carvalho, M."Effects of perillyl alcohol in glial C6 cell line in vitro and anti-metastatic activity in chorioallantoic membrane model". International Journal of Molecular Medicine 10, no. 6 (2002): 785-788. https://doi.org/10.3892/ijmm.10.6.785