Cholesteryl esters in human malignant neoplasms

  • Authors:
    • M. R. Tosi
    • G. Bottura
    • P. Lucchi
    • A. Reggiani
    • A. Trinchero
    • V. Tugnoli
  • View Affiliations

  • Published online on: January 1, 2003     https://doi.org/10.3892/ijmm.11.1.95
  • Pages: 95-98
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Abstract

Cholesteryl esters (CholE) were detected in human malignant neoplasms by means of in vitro nuclear magnetic resonance spectroscopy. Spectroscopic analysis of the total lipid extracts obtained from cerebral tumors revealed appreciable amount of esterified cholesterol in high grade gliomas such as glioblastomas and anaplastic oligodendrogliomas, characterized by prominent neovascularity. The finding that no CholE were detected in the healthy brain and in low grade and benign tumors supports a possible correlation between this class of lipids and histological vascular proliferation. Compared with high grade gliomas, renal cell carcinomas show higher levels of CholE, absent in the healthy renal parenchyma and in benign oncocytomas. In nefro-carcinomas, cytoplasmic lipid inclusions and prominent vascularization contribute to the increased levels of CholE present mainly as oleate. CholE are discussed as potential biochemical markers of cancer and as a target for new therapeutic strategies.

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January 2003
Volume 11 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Tosi MR, Bottura G, Lucchi P, Reggiani A, Trinchero A and Tugnoli V: Cholesteryl esters in human malignant neoplasms. Int J Mol Med 11: 95-98, 2003
APA
Tosi, M.R., Bottura, G., Lucchi, P., Reggiani, A., Trinchero, A., & Tugnoli, V. (2003). Cholesteryl esters in human malignant neoplasms. International Journal of Molecular Medicine, 11, 95-98. https://doi.org/10.3892/ijmm.11.1.95
MLA
Tosi, M. R., Bottura, G., Lucchi, P., Reggiani, A., Trinchero, A., Tugnoli, V."Cholesteryl esters in human malignant neoplasms". International Journal of Molecular Medicine 11.1 (2003): 95-98.
Chicago
Tosi, M. R., Bottura, G., Lucchi, P., Reggiani, A., Trinchero, A., Tugnoli, V."Cholesteryl esters in human malignant neoplasms". International Journal of Molecular Medicine 11, no. 1 (2003): 95-98. https://doi.org/10.3892/ijmm.11.1.95