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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2003 Volume 11 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

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February 2003 Volume 11 Issue 2

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Article

Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth

  • Authors:
    • Laura Del Pup
    • Anna S. Belloni
    • Gianni Carraro
    • Sergio De Angeli
    • Pier Paolo Parnigotto
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Sciences, Section of Anatomy, University of Padua, I-35121 Padua, Italy
  • Pages: 157-160
    |
    Published online on: February 1, 2003
       https://doi.org/10.3892/ijmm.11.2.157
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Abstract

Adrenomedullin (AM) is a hypotensive peptide, which originates from the proteolytic cleavage of pro(p)AM and acts via AM22-52-sensitive receptors. Reverse transcription polymerase chain reaction allowed the detection of the specific mRNAs of pAM in the mononuclear hematopoietic cells of the cord blood and immunocytochemistry demonstrated their abundant AM-immunoreactivity. AM (10−8 M) markedly enhanced clonal growth of cord blood hematopoietic cells cultured on semisolid media added with stem cell-growth promoting cytokines, and this effect was abolished by AM22-52 (10−6 M). Collectively, these findings indicate that AM is expressed in and stimulates the proliferation of cord blood hematopoietic stem cells. Cord blood has been proposed as a source of stem cells alternative to bone marrow for allogeneic transplantation, and our study suggests that AM may be used, in addition to the classic cytokines, to expand in vitro cord blood stem cells in advance of their clinical use.

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Copy and paste a formatted citation
Spandidos Publications style
Del Pup L, Belloni AS, Carraro G, De Angeli S, Parnigotto PP and Nussdorfer GG: Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth. Int J Mol Med 11: 157-160, 2003.
APA
Del Pup, L., Belloni, A.S., Carraro, G., De Angeli, S., Parnigotto, P.P., & Nussdorfer, G.G. (2003). Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth. International Journal of Molecular Medicine, 11, 157-160. https://doi.org/10.3892/ijmm.11.2.157
MLA
Del Pup, L., Belloni, A. S., Carraro, G., De Angeli, S., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth". International Journal of Molecular Medicine 11.2 (2003): 157-160.
Chicago
Del Pup, L., Belloni, A. S., Carraro, G., De Angeli, S., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth". International Journal of Molecular Medicine 11, no. 2 (2003): 157-160. https://doi.org/10.3892/ijmm.11.2.157
Copy and paste a formatted citation
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Spandidos Publications style
Del Pup L, Belloni AS, Carraro G, De Angeli S, Parnigotto PP and Nussdorfer GG: Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth. Int J Mol Med 11: 157-160, 2003.
APA
Del Pup, L., Belloni, A.S., Carraro, G., De Angeli, S., Parnigotto, P.P., & Nussdorfer, G.G. (2003). Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth. International Journal of Molecular Medicine, 11, 157-160. https://doi.org/10.3892/ijmm.11.2.157
MLA
Del Pup, L., Belloni, A. S., Carraro, G., De Angeli, S., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth". International Journal of Molecular Medicine 11.2 (2003): 157-160.
Chicago
Del Pup, L., Belloni, A. S., Carraro, G., De Angeli, S., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin is expressed in cord blood hematopoietic cells and stimulates their clonal growth". International Journal of Molecular Medicine 11, no. 2 (2003): 157-160. https://doi.org/10.3892/ijmm.11.2.157
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