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Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase

  • Authors:
    • Ernest Kun
    • Eva Kirsten
    • Jerome Mendeleyev

  • View Affiliations

  • Published online on: February 1, 2003     https://doi.org/10.3892/ijmm.11.2.191
  • Pages: 191-193
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Abstract

The synergistic interaction of two ligands (INH2BP and the prodrug INO2BA) of PARP I has been demonstrated for two human leukemia cell lines (855-2 and HL-60), for a human lung cancer cell (A549) and for Eras 20 cancer cells. Synergism was calculated using kinetic combination constants based on cell multiplication rates. Reducing cellular GSH content by BSO strongly augmented synergism, an effect partly explained by the removal of C-NO scavenging (by GSH). However, INH2BP action was augmented by BSO, an effect most probably explained by the sensitization of the cell to apoptosis by GSH removal.

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Journal Cover

February 2003
Volume 11 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Kun E, Kirsten E and Mendeleyev J: Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. Int J Mol Med 11: 191-193, 2003
APA
Kun, E., Kirsten, E., & Mendeleyev, J. (2003). Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase. International Journal of Molecular Medicine, 11, 191-193. https://doi.org/10.3892/ijmm.11.2.191
MLA
Kun, E., Kirsten, E., Mendeleyev, J."Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase". International Journal of Molecular Medicine 11.2 (2003): 191-193.
Chicago
Kun, E., Kirsten, E., Mendeleyev, J."Synergistic anticancer action of reversibly and irreversibly acting ligands of poly (ADP-ribose) polymerase". International Journal of Molecular Medicine 11, no. 2 (2003): 191-193. https://doi.org/10.3892/ijmm.11.2.191