Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock

  • Authors:
    • Balazs Toth
    • Martin G. Schwacha
    • Joachim F. Kuebler
    • Kirby I. Bland
    • Ping Wang
    • Irshad H. Chaudrya
  • View Affiliations

  • Published online on: March 1, 2003     https://doi.org/10.3892/ijmm.11.3.357
  • Pages: 357-364
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Abstract

Although gender influences T-cell, macrophage and organ functions following trauma-hemorrhage and resuscitation (T-H), it remains unknown whether it also influences polymorphonuclear cell (PMN) activity under such conditions. To study this, proestrus female and male Sprague-Dawley rats underwent trauma-hemorrhage followed by fluid resuscitation. Circulating PMNs were assessed for superoxide (O2-) and elastase production and tissues were analyzed for myeloperoxidase (MPO) activity and TBARS (thiobarbituric acid reactive substances) as a marker of oxidative injury, at 2 and 24 h after resuscitation. PMA stimulated O2- production was not influenced by T-H or gender. In contrast, fMLP-stimulated O2- and LPS-stimulated elastase release by PMNs from male T-H rats was greater than that of females. A significant MPO activity and TBARS in tissues of both male and female rats was induced; however, MPO activity and TBARS levels were higher in males following T-H. Levels of the chemokine CINC-1 were elevated in the lungs of male, but not of proestrus females after T-H. Thus, decreased PMN priming and activation in proestrus females, compared to males, occurs following T-H resulting in decreased cellular injury and organ damage that is likely to contribute to improved outcome under those conditions.

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March 2003
Volume 11 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Toth B, Schwacha MG, Kuebler JF, Bland KI, Wang P and Chaudrya IH: Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock. Int J Mol Med 11: 357-364, 2003
APA
Toth, B., Schwacha, M.G., Kuebler, J.F., Bland, K.I., Wang, P., & Chaudrya, I.H. (2003). Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock. International Journal of Molecular Medicine, 11, 357-364. https://doi.org/10.3892/ijmm.11.3.357
MLA
Toth, B., Schwacha, M. G., Kuebler, J. F., Bland, K. I., Wang, P., Chaudrya, I. H."Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock". International Journal of Molecular Medicine 11.3 (2003): 357-364.
Chicago
Toth, B., Schwacha, M. G., Kuebler, J. F., Bland, K. I., Wang, P., Chaudrya, I. H."Gender dimorphism in neutrophil priming and activation following trauma-hemorrhagic shock". International Journal of Molecular Medicine 11, no. 3 (2003): 357-364. https://doi.org/10.3892/ijmm.11.3.357