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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2003 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis

  • Authors:
    • Jiangyong Miao
    • Takeshi Kusafuka
    • Seika Kuroda
    • Akihiro Yoneda
    • Zhiwei Zhou
    • Akira Okada

  • View Affiliations / Copyright

    Affiliations: Department of Pediatric Surgery, Osaka University Medical School, Suita, Osaka, Japan
  • Pages: 461-464
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijmm.11.4.461
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Abstract

β-catenin serves not only as a structural component of the E-cadherin-mediated cell-cell adhesion system, but also as a signaling molecule of the Wnt/wingless pathway. Mutations of β-catenin and aberrant expression of its protein have been identified in a number of different types of human malignancies. To determine the role of β-catenin in solid and cystic tumor (SCT) of the pancreas, a rare neoplasm usually observed in young females, we examined three primary tumors and one corresponding liver metastatic tumor presented in pediatric patients. Single strand conformation polymorphism and neucleotide sequencing analysis confirmed a TCT↷TTT somatic mutation at codon 37 changing serine to phenylalanine in one of the primary tumors and its corresponding metastatic tumor. Immunohistochemical analysis displayed abnormally strong nuclear and widespread cytoplasmic expression of β-catenin in these tumors with the mutation. Our observations suggest that, in some SCTs of the pancreas presented in the pediatric age group, mutated β-catenin has an important oncogenic effect.

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Copy and paste a formatted citation
Spandidos Publications style
Miao J, Kusafuka T, Kuroda S, Yoneda A, Zhou Z and Okada A: Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis. Int J Mol Med 11: 461-464, 2003.
APA
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., & Okada, A. (2003). Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis. International Journal of Molecular Medicine, 11, 461-464. https://doi.org/10.3892/ijmm.11.4.461
MLA
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., Okada, A."Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis". International Journal of Molecular Medicine 11.4 (2003): 461-464.
Chicago
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., Okada, A."Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis". International Journal of Molecular Medicine 11, no. 4 (2003): 461-464. https://doi.org/10.3892/ijmm.11.4.461
Copy and paste a formatted citation
x
Spandidos Publications style
Miao J, Kusafuka T, Kuroda S, Yoneda A, Zhou Z and Okada A: Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis. Int J Mol Med 11: 461-464, 2003.
APA
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., & Okada, A. (2003). Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis. International Journal of Molecular Medicine, 11, 461-464. https://doi.org/10.3892/ijmm.11.4.461
MLA
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., Okada, A."Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis". International Journal of Molecular Medicine 11.4 (2003): 461-464.
Chicago
Miao, J., Kusafuka, T., Kuroda, S., Yoneda, A., Zhou, Z., Okada, A."Mutation of β-catenin and its protein accumulation in solid and cystic tumor of the pancreas associated with metastasis". International Journal of Molecular Medicine 11, no. 4 (2003): 461-464. https://doi.org/10.3892/ijmm.11.4.461
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