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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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April 2003 Volume 11 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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April 2003 Volume 11 Issue 4

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Article

Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3

  • Authors:
    • Zhong-Ying Shen
    • Wen-Ying Shen
    • Ming-Hua Chen
    • Jian Shen
    • Yi Zeng

  • View Affiliations / Copyright

    Affiliations: Department of Pathology, Medicine College of Shantou University, Shantou 515031, P.R. China. zhongyingshen@yahoo.com
  • Pages: 479-484
    |
    Published online on: April 1, 2003
       https://doi.org/10.3892/ijmm.11.4.479
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Abstract

To explore the relationship between the reactive oxygen species (ROS) and apoptosis in esophageal carcinoma cells (SHEE85) induced by arsenic trioxide (As2O3), we focused on changes of apoptosis, ROS, and antioxidants. Apoptosis of SHEE85 was confirmed by means of DNA fragmentation stained by Hoechst 33342, Sub-G1 cells scored by flow cytometry and ultrastructure of cells by electron microscopy. To evaluate the level of ROS, the chemiluminescent method was used for measuring the production of superoxide anion (O−__AMB__dot;2). Lipid peroxide (malondialdehyde, MDA), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) were measured respectively by the photometry method. In the cells treated with As2O3 at a concentration of 5.0 µmol/l for 2-24 h, the content of cellular O−__AMB__dot;2 and MDA was increased, but SOD and GSH-Px were significantly lower in the process of apoptosis in SHEE85. As2O3 at concentration of 0.5 µmol/l did not cause cell apoptosis but promoted cell proliferation. These results suggest that As2O3 at a high dosage (5 µmol/l) causes cell apoptosis and at a low dosage (0.5 µmol/l) causes cell proliferation. The essential mechanisms of cell apoptosis induced by As2O3 may be related to the increase of ROS and decrease of anti-oxidation. ROS and antioxidants participate in the apoptotic pathway of esophageal carcinoma cells.

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Copy and paste a formatted citation
Spandidos Publications style
Shen Z, Shen W, Chen M, Shen J and Zeng Y: Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. Int J Mol Med 11: 479-484, 2003.
APA
Shen, Z., Shen, W., Chen, M., Shen, J., & Zeng, Y. (2003). Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. International Journal of Molecular Medicine, 11, 479-484. https://doi.org/10.3892/ijmm.11.4.479
MLA
Shen, Z., Shen, W., Chen, M., Shen, J., Zeng, Y."Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3". International Journal of Molecular Medicine 11.4 (2003): 479-484.
Chicago
Shen, Z., Shen, W., Chen, M., Shen, J., Zeng, Y."Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3". International Journal of Molecular Medicine 11, no. 4 (2003): 479-484. https://doi.org/10.3892/ijmm.11.4.479
Copy and paste a formatted citation
x
Spandidos Publications style
Shen Z, Shen W, Chen M, Shen J and Zeng Y: Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. Int J Mol Med 11: 479-484, 2003.
APA
Shen, Z., Shen, W., Chen, M., Shen, J., & Zeng, Y. (2003). Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3. International Journal of Molecular Medicine, 11, 479-484. https://doi.org/10.3892/ijmm.11.4.479
MLA
Shen, Z., Shen, W., Chen, M., Shen, J., Zeng, Y."Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3". International Journal of Molecular Medicine 11.4 (2003): 479-484.
Chicago
Shen, Z., Shen, W., Chen, M., Shen, J., Zeng, Y."Reactive oxygen species and antioxidants in apoptosis of esophageal cancer cells induced by As2O3". International Journal of Molecular Medicine 11, no. 4 (2003): 479-484. https://doi.org/10.3892/ijmm.11.4.479
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