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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2003 Volume 11 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2003 Volume 11 Issue 6

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Article

Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma

  • Authors:
    • Er-Bin Yang
    • Liu-Liang Qin
    • Yin-Nong Zhao
    • Kai Zhang
    • Pierce Chow

  • View Affiliations / Copyright

    Affiliations: Department of Experimental Surgery, Singapore General Hospital, Singapore 169608. gesyeb@sgh.com.sg
  • Pages: 773-778
    |
    Published online on: June 1, 2003
       https://doi.org/10.3892/ijmm.11.6.773
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Abstract

It was reported that 60-70% of hepatitis B virus (HBV)-negative hepatocellular carcinoma (HCC) had loss of heterozygosity (LOH) at the mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) locus and this gene was mutated in 55% of these patients with LOH. In this study, genomic DNA from 29 pairs of HBV-positive HCC and corresponding non-tumor tissues was used to analyze LOH at the M6P/IGF2R locus and single deoxyguanosine deletion in this gene by PCR. Total RNA from 19 of the 29 patients was utilized to determine a 192 bp insert in the M6P/IGF2R mRNA and expression of this gene by RT-PCR. Twenty-eight of 29 (97%) HBV-positive HCC were found to be informative at the M6P/IGF2R locus but LOH at this region was only detected in 4/28 (14%) informative patients. Neither single deoxyguanosine deletion in this gene nor 192 bp insert in its mRNA occurred in these patients. Compared with corresponding non-tumor tissues, expression of the M6P/IGF2R mRNA was decreased in 13/19 (68%) HBV-positive HCC tissues, suggesting that M6P/IGF2R may be involved in HBV-associated hepatocarcinogenesis by the regulation of its expression level. In the development of HBV-associated HCC, M6P/IGF2R mutation may not be a major agent.

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Copy and paste a formatted citation
Spandidos Publications style
Yang E, Qin L, Zhao Y, Zhang K and Chow P: Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. Int J Mol Med 11: 773-778, 2003.
APA
Yang, E., Qin, L., Zhao, Y., Zhang, K., & Chow, P. (2003). Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. International Journal of Molecular Medicine, 11, 773-778. https://doi.org/10.3892/ijmm.11.6.773
MLA
Yang, E., Qin, L., Zhao, Y., Zhang, K., Chow, P."Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma". International Journal of Molecular Medicine 11.6 (2003): 773-778.
Chicago
Yang, E., Qin, L., Zhao, Y., Zhang, K., Chow, P."Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma". International Journal of Molecular Medicine 11, no. 6 (2003): 773-778. https://doi.org/10.3892/ijmm.11.6.773
Copy and paste a formatted citation
x
Spandidos Publications style
Yang E, Qin L, Zhao Y, Zhang K and Chow P: Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. Int J Mol Med 11: 773-778, 2003.
APA
Yang, E., Qin, L., Zhao, Y., Zhang, K., & Chow, P. (2003). Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. International Journal of Molecular Medicine, 11, 773-778. https://doi.org/10.3892/ijmm.11.6.773
MLA
Yang, E., Qin, L., Zhao, Y., Zhang, K., Chow, P."Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma". International Journal of Molecular Medicine 11.6 (2003): 773-778.
Chicago
Yang, E., Qin, L., Zhao, Y., Zhang, K., Chow, P."Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma". International Journal of Molecular Medicine 11, no. 6 (2003): 773-778. https://doi.org/10.3892/ijmm.11.6.773
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