Structure of curcumin in complex with lipoxygenase and its significance in cancer

  • Authors:
    • Ewa Skrzypczak-Jankun
    • Kangjing Zhou
    • N. Patrick McCabe
    • Steven H. Selman
    • Jerzy Jankun
  • View Affiliations

  • Published online on: July 1, 2003     https://doi.org/10.3892/ijmm.12.1.17
  • Pages: 17-24
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Abstract

Scientific research provides documented evidence that fatty acid metabolites have profound impact on carcinogenesis. Intervention into dioxygenase pathways might therefore effect development, metastasis and progression of many types of cancers. This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase in a non-competitive manner. Trapped in that complex, it undergoes photodegradation in the X-rays, but utilizes enzyme catalytic ability to form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our observations about this radiation and time-dependent inhibition add new information to the role that curcumin might play in cancer prevention and treatment.

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July 2003
Volume 12 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH and Jankun J: Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 12: 17-24, 2003
APA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N.P., Selman, S.H., & Jankun, J. (2003). Structure of curcumin in complex with lipoxygenase and its significance in cancer. International Journal of Molecular Medicine, 12, 17-24. https://doi.org/10.3892/ijmm.12.1.17
MLA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12.1 (2003): 17-24.
Chicago
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12, no. 1 (2003): 17-24. https://doi.org/10.3892/ijmm.12.1.17