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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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July 2003 Volume 12 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July 2003 Volume 12 Issue 1

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Article

Structure of curcumin in complex with lipoxygenase and its significance in cancer

  • Authors:
    • Ewa Skrzypczak-Jankun
    • Kangjing Zhou
    • N. Patrick McCabe
    • Steven H. Selman
    • Jerzy Jankun
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Urology Research Center, Medical College of Ohio, Toledo, OH 43614-5807, USA
  • Pages: 17-24
    |
    Published online on: July 1, 2003
       https://doi.org/10.3892/ijmm.12.1.17
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Abstract

Scientific research provides documented evidence that fatty acid metabolites have profound impact on carcinogenesis. Intervention into dioxygenase pathways might therefore effect development, metastasis and progression of many types of cancers. This work delivers the first 3D structural data and explains how curcumin interacts with the fatty acid metabolizing enzyme, soybean lipoxygenase. Curcumin binds to lipoxygenase in a non-competitive manner. Trapped in that complex, it undergoes photodegradation in the X-rays, but utilizes enzyme catalytic ability to form the peroxy complex Enz-Fe-O-O-R as 4-hydroperoxy-2-methoxy-phenol, that later transforms into 2-methoxycyclohexa-2,5-diene-1,4-dione. Our observations about this radiation and time-dependent inhibition add new information to the role that curcumin might play in cancer prevention and treatment.

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Copy and paste a formatted citation
Spandidos Publications style
Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH and Jankun J: Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 12: 17-24, 2003.
APA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N.P., Selman, S.H., & Jankun, J. (2003). Structure of curcumin in complex with lipoxygenase and its significance in cancer. International Journal of Molecular Medicine, 12, 17-24. https://doi.org/10.3892/ijmm.12.1.17
MLA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12.1 (2003): 17-24.
Chicago
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12, no. 1 (2003): 17-24. https://doi.org/10.3892/ijmm.12.1.17
Copy and paste a formatted citation
x
Spandidos Publications style
Skrzypczak-Jankun E, Zhou K, McCabe NP, Selman SH and Jankun J: Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 12: 17-24, 2003.
APA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N.P., Selman, S.H., & Jankun, J. (2003). Structure of curcumin in complex with lipoxygenase and its significance in cancer. International Journal of Molecular Medicine, 12, 17-24. https://doi.org/10.3892/ijmm.12.1.17
MLA
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12.1 (2003): 17-24.
Chicago
Skrzypczak-Jankun, E., Zhou, K., McCabe, N. P., Selman, S. H., Jankun, J."Structure of curcumin in complex with lipoxygenase and its significance in cancer". International Journal of Molecular Medicine 12, no. 1 (2003): 17-24. https://doi.org/10.3892/ijmm.12.1.17
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