A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-γ receptor 1 gene associated with allergic diseases

Aoki,Minako; Matsui,Eiko; Kaneko,Hideo; Inoue,Ryosuke; Fukao,Toshiyuki; Watanabe,Mizuho; Teramoto,Takahide; Kato,Zenichiro; Suzuki,Kiyotaka; Suzuki,Yasuyuki; Kasahara,Kimiko; Kondo,Naomi

doi:10.3892/ijmm.12.2.185

August 2003 Volume 12 Issue 2

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August 2003 Volume 12 Issue 2

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Article

A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-γ receptor 1 gene associated with allergic diseases

Authors:
- Minako Aoki
- Eiko Matsui
- Hideo Kaneko
- Ryosuke Inoue
- Toshiyuki Fukao
- Mizuho Watanabe
- Takahide Teramoto
- Zenichiro Kato
- Kiyotaka Suzuki
- Yasuyuki Suzuki
- Kimiko Kasahara
- Naomi Kondo
View Affiliations / Copyright

Affiliations: Department of Pediatrics, Gifu University School of Medicine, Gifu 500-8705, Japan. e2104001@guedu.cc.gifu-u.ac.jp
Pages: 185-191
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Published online on: August 1, 2003

https://doi.org/10.3892/ijmm.12.2.185
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Abstract

We identified a novel heterozygous single-nucleotide substitution 1400 T↷C (Leu 467 Pro) in the seventh exon of the interferon-γ receptor 1 (IFNGR1) gene. This substitution was detected in 6 of the 89 allergic patients but not in the 72 non-allergic subjects. There was a difference in the L467P frequency between the allergic patients and the non-allergic subjects (Fisher's exact test: p=0.033). The 6 patients with L467P have allergic diseases such as bronchial asthma and/or allergic rhinitis. Furthermore, a familial analysis for L467P revealed a linkage between allergic diseases and L467P. Serum IgE levels of the patients with L467P were higher than those of the non-allergic subjects (p=0.001). Our previous studies have been shown that interferon-γ (IFN-γ) production by PBMCs in the allergic patients was lower than that in the non-allergic subjects. In this study, although IFN-γ production in the allergic patients with L467P was equivalent to that in the non-allergic subjects, their serum IgE levels were high and they had allergic diseases. Our results suggest that some allergic patients have IFNGR dysfunction, and that L467P in the IFNGR1 gene is one of candidate susceptibility genes for allergic diseases.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-γ receptor 1 gene associated with allergic diseases

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