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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2003 Volume 12 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2003 Volume 12 Issue 2

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Article

Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate

  • Authors:
    • Rahali Youssef
    • Willy J. Malaisse
    • Philippe Courtois
    • Abdullah Sener

  • View Affiliations / Copyright

    Affiliations: Laboratory of Experimental Hormonology, Brussels Free University, B-1070 Brussels, Belgium
  • Pages: 199-200
    |
    Published online on: August 1, 2003
       https://doi.org/10.3892/ijmm.12.2.199
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Abstract

A sufficient availability of the bicarbonate anion is required to allow a normal process of glucose-stimulated insulin release. Thus, both the removal of extracellular bicarbonate and the inhibition of carbonic anhydrase by acetazolamide suppress the insulinotropic action of glucose. In the present study, a comparable situation is documented in rat parotid cells. Thus, the absence of extracellular bicarbonate is shown to decrease by about 50% basal α-amylase secretion, as well as carbamylcholine- and isoproterenol-stimulated α-amylase output, without suppressing the enhancing action of the two agents. It is proposed, therefore, that the HCO3−anion participates in the secretory sequence at sites distal to the identification of secretagogues in both endocrine and exocrine cells.

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Copy and paste a formatted citation
Spandidos Publications style
Youssef R, Malaisse WJ, Courtois P and Sener A: Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate. Int J Mol Med 12: 199-200, 2003.
APA
Youssef, R., Malaisse, W.J., Courtois, P., & Sener, A. (2003). Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate. International Journal of Molecular Medicine, 12, 199-200. https://doi.org/10.3892/ijmm.12.2.199
MLA
Youssef, R., Malaisse, W. J., Courtois, P., Sener, A."Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate". International Journal of Molecular Medicine 12.2 (2003): 199-200.
Chicago
Youssef, R., Malaisse, W. J., Courtois, P., Sener, A."Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate". International Journal of Molecular Medicine 12, no. 2 (2003): 199-200. https://doi.org/10.3892/ijmm.12.2.199
Copy and paste a formatted citation
x
Spandidos Publications style
Youssef R, Malaisse WJ, Courtois P and Sener A: Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate. Int J Mol Med 12: 199-200, 2003.
APA
Youssef, R., Malaisse, W.J., Courtois, P., & Sener, A. (2003). Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate. International Journal of Molecular Medicine, 12, 199-200. https://doi.org/10.3892/ijmm.12.2.199
MLA
Youssef, R., Malaisse, W. J., Courtois, P., Sener, A."Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate". International Journal of Molecular Medicine 12.2 (2003): 199-200.
Chicago
Youssef, R., Malaisse, W. J., Courtois, P., Sener, A."Alteration of α-amylase secretion from rat parotid cells in the absence of extracellular bicarbonate". International Journal of Molecular Medicine 12, no. 2 (2003): 199-200. https://doi.org/10.3892/ijmm.12.2.199
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