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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
August 2003 Volume 12 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2003 Volume 12 Issue 2

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Article

Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer

  • Authors:
    • Jane Lane
    • Robert E. Mansel
    • Wen G. Jiang

  • View Affiliations / Copyright

    Affiliations: Metastasis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, UK
  • Pages: 253-257
    |
    Published online on: August 1, 2003
       https://doi.org/10.3892/ijmm.12.2.253
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Abstract

Highly unsaturated fatty acids (HUFAs) are cyto-toxic to cancer cells and generated in the body by desaturation from essential fatty acids, primarily involving delta-6-desaturase. This study, for the first time, examined the level of expression of human delta-6-desaturase as well as delta-4-desaturase in human breast cancer. Breast tumours (n=102) which comprised of 88 ductal and 14 lobular carcinomas, as well as normal breast tissues (n=31), together with breast cancer cell lines were analysed for the level of expression of delta-6- and delta-4-desaturases using RT-PCR and quantitative PCR. A lower level of delta-6-desaturase was seen in breast tumour compared with normal tissues. Tumours from patients who had a poor prognostic index and from those who died of breast cancer had the lowest level of delta-6-desaturase (median follow-up 72 months). In addition, TNM3 and TNM4 tumours had significantly lower level of delta-6-desaturase than TNM1 tumours. Interestingly, ductal tumours displayed significantly higher level of the enzyme than lobular tumours. In contrast, a stepwise increase of delta-4-desaturase was seen in tumour from patients with poor prognosis. It is concluded that aggressive breast tumours have a reduced level of delta-6-desaturase. This aberrant expression has clinical bearings to the outcome in patients with breast cancer.

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Copy and paste a formatted citation
Spandidos Publications style
Lane J, Mansel RE and Jiang WG: Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. Int J Mol Med 12: 253-257, 2003.
APA
Lane, J., Mansel, R.E., & Jiang, W.G. (2003). Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. International Journal of Molecular Medicine, 12, 253-257. https://doi.org/10.3892/ijmm.12.2.253
MLA
Lane, J., Mansel, R. E., Jiang, W. G."Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer". International Journal of Molecular Medicine 12.2 (2003): 253-257.
Chicago
Lane, J., Mansel, R. E., Jiang, W. G."Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer". International Journal of Molecular Medicine 12, no. 2 (2003): 253-257. https://doi.org/10.3892/ijmm.12.2.253
Copy and paste a formatted citation
x
Spandidos Publications style
Lane J, Mansel RE and Jiang WG: Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. Int J Mol Med 12: 253-257, 2003.
APA
Lane, J., Mansel, R.E., & Jiang, W.G. (2003). Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer. International Journal of Molecular Medicine, 12, 253-257. https://doi.org/10.3892/ijmm.12.2.253
MLA
Lane, J., Mansel, R. E., Jiang, W. G."Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer". International Journal of Molecular Medicine 12.2 (2003): 253-257.
Chicago
Lane, J., Mansel, R. E., Jiang, W. G."Expression of human delta-6-desaturase is associated with aggressiveness of human breast cancer". International Journal of Molecular Medicine 12, no. 2 (2003): 253-257. https://doi.org/10.3892/ijmm.12.2.253
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