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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 12 Issue 4

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Article

Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport

  • Authors:
    • Timothy M. Pawlik
    • Edward A. Carter
    • Barry P. Bode
    • Alan J. Fischman
    • Ronald G. Tompkins

  • View Affiliations / Copyright

    Affiliations: Department of Surgical Oncology - 444, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. tmpawlik@mdanderson.org
  • Pages: 541-548
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.541
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Abstract

Burn injury produces a marked and prolonged hypermetabolic state, which is characterized by accelerated hepatic amino acid metabolism and negative nitrogen balance. The effect of burn injury on hepatocyte transport of glutamine, a key substrate in gluconeogenesis and ureagenesis, was examined following the administration of a full thickness 20% total body surface scald injury. The burn injury was induced in wild-type mice, as well as two types of knockout mice: a CD-14 knockout and an interleukin-6 (IL-6) knockout. In both the wild-type and CD-14 knockout mice a latent and profound 2-fold increase in hepatocyte glutamine transport was seen. In contrast, hepatocytes isolated from IL-6 knockout mice failed to show an induction of glutamine transport after burn injury. Hepatocytes isolated from burned wild-type and CD-14 knockout mice produced significantly higher levels of IL-6 as compared to hepatocytes isolated from sham burned mice. Histologic analysis of skin isolated from wild-type mice showed a robust inflammatory response whereas skin from IL-6 deficient mice showed minimal inflammation and decreased granulation tissue. The results of this study suggest that IL-6 may play a key role in the stimulation of hepatic glutamine transport following burn injury.

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Copy and paste a formatted citation
Spandidos Publications style
Pawlik TM, Carter EA, Bode BP, Fischman AJ and Tompkins RG: Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport. Int J Mol Med 12: 541-548, 2003.
APA
Pawlik, T.M., Carter, E.A., Bode, B.P., Fischman, A.J., & Tompkins, R.G. (2003). Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport. International Journal of Molecular Medicine, 12, 541-548. https://doi.org/10.3892/ijmm.12.4.541
MLA
Pawlik, T. M., Carter, E. A., Bode, B. P., Fischman, A. J., Tompkins, R. G."Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport". International Journal of Molecular Medicine 12.4 (2003): 541-548.
Chicago
Pawlik, T. M., Carter, E. A., Bode, B. P., Fischman, A. J., Tompkins, R. G."Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport". International Journal of Molecular Medicine 12, no. 4 (2003): 541-548. https://doi.org/10.3892/ijmm.12.4.541
Copy and paste a formatted citation
x
Spandidos Publications style
Pawlik TM, Carter EA, Bode BP, Fischman AJ and Tompkins RG: Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport. Int J Mol Med 12: 541-548, 2003.
APA
Pawlik, T.M., Carter, E.A., Bode, B.P., Fischman, A.J., & Tompkins, R.G. (2003). Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport. International Journal of Molecular Medicine, 12, 541-548. https://doi.org/10.3892/ijmm.12.4.541
MLA
Pawlik, T. M., Carter, E. A., Bode, B. P., Fischman, A. J., Tompkins, R. G."Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport". International Journal of Molecular Medicine 12.4 (2003): 541-548.
Chicago
Pawlik, T. M., Carter, E. A., Bode, B. P., Fischman, A. J., Tompkins, R. G."Central role of interleukin-6 in burn induced stimulation of hepatic amino acid transport". International Journal of Molecular Medicine 12, no. 4 (2003): 541-548. https://doi.org/10.3892/ijmm.12.4.541
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