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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2003 Volume 12 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2003 Volume 12 Issue 4

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Article

Inhibition of signal transduction in EGF-dependent epithelial cell lines

  • Authors:
    • U. Wollina
    • A. Frenkl
    • B. Knöll
    • U.-C. Hipler
    • R. Wetzker

  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, Krankenhaus Dresden-Friedrichstadt, 01067 Dresden, Germany. wollina-uw@khdf.de
  • Pages: 673-677
    |
    Published online on: October 1, 2003
       https://doi.org/10.3892/ijmm.12.4.673
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Abstract

The epidermal growth factor (EGF) receptor plays a pivotal role in growth regulation of epidermal keratinocytes. Its expression and function can be markedly altered during malignant transformation in squamous cell carcinoma. The present study investigated the potential of growth inhibition by signal-transduction inhibitors in EGF-dependent epithelial cell lines in vitro. Benign HaCaT keratinocytes and malignant A431 cells were grown in vitro and exposed to various concentrations of a panel of eleven kinase and phosphodiesterase inhibitors. Cell growth was measured after 24 h and 48 h using fluorescence labeling with Hoechst 33342 and propidium iodide. Significant growth inhibition was achieved with all inhibitors when applied to HaCaT cells. The strongest growth inhibition was achieved with inhibitors H-7, A3 and diacylglycerol kinase inhibitors I and II. A431 cells were inhibited significantly by H-7, A3 and H-9. Selected signal-transduction inhibitors such as A3, H-7 and H-9 acting on intracellular kinases are capable of suppressing growth of EGF-dependent benign and malignant epithelial cell lines in vitro. They might be of future potential in the treatment of epithelial cancer but further studies are necessary.

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Copy and paste a formatted citation
Spandidos Publications style
Wollina U, Frenkl A, Knöll B, Hipler U and Wetzker R: Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med 12: 673-677, 2003.
APA
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., & Wetzker, R. (2003). Inhibition of signal transduction in EGF-dependent epithelial cell lines. International Journal of Molecular Medicine, 12, 673-677. https://doi.org/10.3892/ijmm.12.4.673
MLA
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., Wetzker, R."Inhibition of signal transduction in EGF-dependent epithelial cell lines". International Journal of Molecular Medicine 12.4 (2003): 673-677.
Chicago
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., Wetzker, R."Inhibition of signal transduction in EGF-dependent epithelial cell lines". International Journal of Molecular Medicine 12, no. 4 (2003): 673-677. https://doi.org/10.3892/ijmm.12.4.673
Copy and paste a formatted citation
x
Spandidos Publications style
Wollina U, Frenkl A, Knöll B, Hipler U and Wetzker R: Inhibition of signal transduction in EGF-dependent epithelial cell lines. Int J Mol Med 12: 673-677, 2003.
APA
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., & Wetzker, R. (2003). Inhibition of signal transduction in EGF-dependent epithelial cell lines. International Journal of Molecular Medicine, 12, 673-677. https://doi.org/10.3892/ijmm.12.4.673
MLA
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., Wetzker, R."Inhibition of signal transduction in EGF-dependent epithelial cell lines". International Journal of Molecular Medicine 12.4 (2003): 673-677.
Chicago
Wollina, U., Frenkl, A., Knöll, B., Hipler, U., Wetzker, R."Inhibition of signal transduction in EGF-dependent epithelial cell lines". International Journal of Molecular Medicine 12, no. 4 (2003): 673-677. https://doi.org/10.3892/ijmm.12.4.673
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