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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants

  • Authors:
    • Kazuki Harada
    • Mami Ando
    • Tomoko Fujimura-Ito
    • Mika Kasahara-Imamura
    • Yoshihiko Sako
    • Aritsune Uchida
    • Yuzaburo Ishida
    • Hajime Kadota
    • Takeo Ohnishi
    • Bevan E.B. Moseley

  • View Affiliations / Copyright

    Affiliations: Laboratory of Biotechnology, Department of Food Science and Technology, National Fisheries University, Independent Administrative Institution, The Ministry of Agriculture, Forestry and Fisheries of Japan, Shimonoseki-shi, Yamaguchi 759-6595, Japan. kazuki@fish-u.ac.jp
  • Pages: 741-747
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.741
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Abstract

We examined the phenomenon of thermotolerance induction in the radioresistant prokaryote, Deinococcus radiodurans, which was initially exposed to 30 min at 52°C followed by various intervals up to 6 h at 30°C in TGY medium and then re-exposed to 52°C for various periods, i.e., split-dose hyperthermia. This thermotolerance induction was analyzed in DNA repair deficient mutants (strain 302, 251, UVS25, rec30 and KH840) and the wild-type strain MR1. The strain UVS25 is a double mutant for the mtcA and uvsD genes, and strain rec30 is a mutant for the deinococcal recA gene. The induction was suppressed to 1/10 and 1/25 in strains UVS25 and rec30 respectively, as compared with the maximum level in the wild-type strain MR1. However, the induction in strain 302 (mutant for the uvrA gene) was not suppressed. Therefore, we conclude that proteins synthesized during the interexposure interval, i.e., the products of the uvsD (UV endonuclease β) and recA (RecA protein) genes contribute to the induction of thermotolerance in D. radiodurans.

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Copy and paste a formatted citation
Spandidos Publications style
Harada K, Ando M, Fujimura-Ito T, Kasahara-Imamura M, Sako Y, Uchida A, Ishida Y, Kadota H, Ohnishi T, Moseley BE, Moseley BE, et al: Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants. Int J Mol Med 12: 741-747, 2003.
APA
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A. ... Moseley, B.E. (2003). Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants. International Journal of Molecular Medicine, 12, 741-747. https://doi.org/10.3892/ijmm.12.5.741
MLA
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A., Ishida, Y., Kadota, H., Ohnishi, T., Moseley, B. E."Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants". International Journal of Molecular Medicine 12.5 (2003): 741-747.
Chicago
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A., Ishida, Y., Kadota, H., Ohnishi, T., Moseley, B. E."Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants". International Journal of Molecular Medicine 12, no. 5 (2003): 741-747. https://doi.org/10.3892/ijmm.12.5.741
Copy and paste a formatted citation
x
Spandidos Publications style
Harada K, Ando M, Fujimura-Ito T, Kasahara-Imamura M, Sako Y, Uchida A, Ishida Y, Kadota H, Ohnishi T, Moseley BE, Moseley BE, et al: Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants. Int J Mol Med 12: 741-747, 2003.
APA
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A. ... Moseley, B.E. (2003). Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants. International Journal of Molecular Medicine, 12, 741-747. https://doi.org/10.3892/ijmm.12.5.741
MLA
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A., Ishida, Y., Kadota, H., Ohnishi, T., Moseley, B. E."Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants". International Journal of Molecular Medicine 12.5 (2003): 741-747.
Chicago
Harada, K., Ando, M., Fujimura-Ito, T., Kasahara-Imamura, M., Sako, Y., Uchida, A., Ishida, Y., Kadota, H., Ohnishi, T., Moseley, B. E."Mechanism of thermotolerance induction by split-dose hyperthermia in Deinococcus radiodurans DNA repair deficient mutants". International Journal of Molecular Medicine 12, no. 5 (2003): 741-747. https://doi.org/10.3892/ijmm.12.5.741
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