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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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November 2003 Volume 12 Issue 5

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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November 2003 Volume 12 Issue 5

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Article

Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis

  • Authors:
    • Xiaoyan Zhao
    • Baback Gharizadeh
    • Peter Hjelmström
    • Ritva Pirskanen
    • Pål Nyrén
    • Ann-Kari Lefvert
    • Mehran Ghaderi

  • View Affiliations / Copyright

    Affiliations: Department of Medicine, Immunological Research Unit, Center for Molecular Medicine, Stockholm, Sweden
  • Pages: 749-753
    |
    Published online on: November 1, 2003
       https://doi.org/10.3892/ijmm.12.5.749
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Abstract

The aim of this study was to examine the association of human autoimmune myasthenia gravis (MG) with two DNA polymorphisms of the chemokine receptors CCR5-Δ32 and CCR2-64I. CCR2 and CCR5 interact primarily with the human CC family ligands CCL2 (formerly called monocyte chemoattractant protein; MCP-1), CCL3 and CCL4 (macrophage inflammatory protein-1α and -1β; MIP-1α/β), and their main function is to recruit leukocytes from circulation into the tissues, thus playing an important role in human inflammatory disorders. A PCR-based genotyping method was used to determine the genetic variation at the CCR5 gene and an automated real-time Pyrosequencing technology was employed for the analysis of G↷A point mutation at the CCR2 gene. Results obtained from 158 patients and 272 healthy controls demonstrate no evidence of association between genetic variants of CCR2 and CCR5 with MG and its clinical manifestations. CCR2-64I and CCR5-Δ32 genotypes are thus unlikely to be involved in protection or predisposition to MG.

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Copy and paste a formatted citation
Spandidos Publications style
Zhao X, Gharizadeh B, Hjelmström P, Pirskanen R, Nyrén P, Lefvert A and Ghaderi M: Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis. Int J Mol Med 12: 749-753, 2003.
APA
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., & Ghaderi, M. (2003). Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis. International Journal of Molecular Medicine, 12, 749-753. https://doi.org/10.3892/ijmm.12.5.749
MLA
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., Ghaderi, M."Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis". International Journal of Molecular Medicine 12.5 (2003): 749-753.
Chicago
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., Ghaderi, M."Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis". International Journal of Molecular Medicine 12, no. 5 (2003): 749-753. https://doi.org/10.3892/ijmm.12.5.749
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao X, Gharizadeh B, Hjelmström P, Pirskanen R, Nyrén P, Lefvert A and Ghaderi M: Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis. Int J Mol Med 12: 749-753, 2003.
APA
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., & Ghaderi, M. (2003). Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis. International Journal of Molecular Medicine, 12, 749-753. https://doi.org/10.3892/ijmm.12.5.749
MLA
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., Ghaderi, M."Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis". International Journal of Molecular Medicine 12.5 (2003): 749-753.
Chicago
Zhao, X., Gharizadeh, B., Hjelmström, P., Pirskanen, R., Nyrén, P., Lefvert, A., Ghaderi, M."Genotypes of CCR2 and CCR5 chemokine receptors in human myasthenia gravis". International Journal of Molecular Medicine 12, no. 5 (2003): 749-753. https://doi.org/10.3892/ijmm.12.5.749
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