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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2003 Volume 12 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 12 Issue 6

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Article

The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells

  • Authors:
    • Hiroshi Okano
    • Katsuya Shiraki
    • Hidekazu Inoue
    • Tomoyuki Kawakita
    • Masatoshi Deguchi
    • Kazushi Sugimoto
    • Takahisa Sakai
    • Kazumoto Murata
    • Takeshi Nakano
    • Munechika Enjoji

  • View Affiliations

    Affiliations: First Department of Internal Medicine, Mie University School of Medicine, Tsu 514-8507, Japan
  • Published online on: December 1, 2003     https://doi.org/10.3892/ijmm.12.6.867
  • Pages: 867-870
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

PPARγ is known to induce apoptosis in malignant tumor cells, but the mechanism of this induction is not well understood. We investigated induction of apoptosis with 15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2), a PPARγ ligand, in cholangio cell carcinoma (CCC) cells (RBE, ETK-1 or HuCCT-1). Apoptosis was induced in RBE and ETK-1 cells with 15d-PGJ2, but not in HuCCT-1 cells, although PPARγ was expressed in all CCC cells. Apoptosis-related proteins were also expressed, including FLIP, bclx, Apaf-1 and XIAP, but expression levels differed among the three cell lines. RBE cells treated with 15d-PGJ2 showed caspase activation, and it appeared that PPARγ-induced apoptosis was dependent on caspase activation. However, neither ETK-1 nor HuCCT-1 cells showed significant activation of caspase-8 or -3 with 15d-PGJ2 treatment, raising the possibility of a caspase-independent apoptosis induction pathway. XIAP was down-regulated by 15d-PGJ2 in all three CCC cell lines. Therefore, 15d-PGJ2 induces apoptosis in CCC cells via caspase-dependent or independent pathways. 15d-PGJ2 may also induce down-regulation of XIAP and may promote caspase cascade activation through TNF-family receptor signaling pathways.

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Copy and paste a formatted citation
Spandidos Publications style
Okano H, Shiraki K, Inoue H, Kawakita T, Deguchi M, Sugimoto K, Sakai T, Murata K, Nakano T, Enjoji M, Enjoji M, et al: The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. Int J Mol Med 12: 867-870, 2003.
APA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K. ... Enjoji, M. (2003). The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. International Journal of Molecular Medicine, 12, 867-870. https://doi.org/10.3892/ijmm.12.6.867
MLA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K., Sakai, T., Murata, K., Nakano, T., Enjoji, M."The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells". International Journal of Molecular Medicine 12.6 (2003): 867-870.
Chicago
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K., Sakai, T., Murata, K., Nakano, T., Enjoji, M."The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells". International Journal of Molecular Medicine 12, no. 6 (2003): 867-870. https://doi.org/10.3892/ijmm.12.6.867
Copy and paste a formatted citation
x
Spandidos Publications style
Okano H, Shiraki K, Inoue H, Kawakita T, Deguchi M, Sugimoto K, Sakai T, Murata K, Nakano T, Enjoji M, Enjoji M, et al: The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. Int J Mol Med 12: 867-870, 2003.
APA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K. ... Enjoji, M. (2003). The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells. International Journal of Molecular Medicine, 12, 867-870. https://doi.org/10.3892/ijmm.12.6.867
MLA
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K., Sakai, T., Murata, K., Nakano, T., Enjoji, M."The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells". International Journal of Molecular Medicine 12.6 (2003): 867-870.
Chicago
Okano, H., Shiraki, K., Inoue, H., Kawakita, T., Deguchi, M., Sugimoto, K., Sakai, T., Murata, K., Nakano, T., Enjoji, M."The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells". International Journal of Molecular Medicine 12, no. 6 (2003): 867-870. https://doi.org/10.3892/ijmm.12.6.867
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