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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December 2003 Volume 12 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Promoter methylation and down-regulation of DAPK is associated with gastric atrophy

Won Seog Kim, Hee Jung Son, Joon Oh Park, Sang Yong Song, Chaehwa Park
Pages: 827-830
Published online on: 01 December 2003

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Article

Differential in vivo and in vitro expression of ED-B+ fibronectin in adult human hematopoiesis

Wichard Vogel, Alexander Berndt, Angelika Müller, Regine Dahse, Karl Michael Haas, Laura Borsi, Luciano Zardi, Hartwig Kosmehl
Pages: 831-837
Published online on: 01 December 2003

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Article

Population study of expression of thymidylate synthase and dihydropyrimidine dehydrogenase in patients with solid tumors

Masakazu Fukushima, Masao Morita, Kazumasa Ikeda, Sekio Nagayama
Pages: 839-844
Published online on: 01 December 2003

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Article

Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: A potent role of hydrogen peroxide as a new radiosensitizer

Yasuhiro Ogawa, Toshiaki Takahashi, Toshihiro Kobayashi, Shinji Kariya, Akihito Nishioka, Takenao Ohnishi, Toshiji Saibara, Shinji Hamasato, Toshikazu Tani, Harumichi Seguchi, Shoji Yoshida, Hiroshi Sonobe
Pages: 845-850
Published online on: 01 December 2003

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Article

Effects of cryopreservation and coculture with pancreatic ductal epithelial cells on insulin secretion from human pancreatic islets

Claudio Gatto, Maura Callegari, Marcella Folin, Maria Teresa Conconi, Adolfo Paolin, Giuseppe Di Falco, Simonetta Bredariol, Raffaella Spinazzi, Pier Paolo Parnigotto, Gastone G. Nussdorfer
Pages: 851-854
Published online on: 01 December 2003

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Article

Immunohistochemical double staining with estrogen receptor and HER2 on primary breast cancer

Jun Horiguchi, Yukio Koibuchi, Kotaro Iijima, Takashi Yoshida, Miho Yoshida, Daisuke Takata, Tetsunari Oyama, Yuichi Iino, Yasuo Morishita
Pages: 855-859
Published online on: 01 December 2003

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Article

The effect of peroxisome proliferator-activated receptor-γ ligand on urological cancer cells

Rikio Yoshimura, Masahide Matsuyama, Taro Hase, Kenji Tsuchida, Katsuyuki Kuratsukuri, Yutaka Kawahito, Hajime Sano, Yoshihiro Segawa, Tatsuya Nakatani
Pages: 861-865
Published online on: 01 December 2003

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Article

The PPARγ ligand, 15-Deoxy-Δ12,14-PGJ2, regulates apoptosis-related protein expression in cholangio cell carcinoma cells

Hiroshi Okano, Katsuya Shiraki, Hidekazu Inoue, Tomoyuki Kawakita, Masatoshi Deguchi, Kazushi Sugimoto, Takahisa Sakai, Kazumoto Murata, Takeshi Nakano, Munechika Enjoji
Pages: 867-870
Published online on: 01 December 2003

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Article

Identification of a trypsinogen activity stimulating factor produced by pancreatic cancer cells: Its role in tumor invasion and metastasis

Yasutake Uchima, Tetsuji Sawada, Tamahiro Nishihara, Toshiyoshi Umekawa, Masaichi Ohira, Tetsuro Ishikawa, Hiroji Nishino, Kosei Hirakawa
Pages: 871-878
Published online on: 01 December 2003

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Article

A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells

Aslamuzzaman Kazi, Daniel A. Urbizu, Deborah J. Kuhn, Abelardo L. Acebo, Edward R. Jackson, Gail P. Greenfelder, Nagi B. Kumar, Q. Ping Dou
Pages: 879-887
Published online on: 01 December 2003

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Article

TNF-α induced DNA damage in primary murine hepatocytes

Nicholas M. Wheelhouse, Yuen-Sum Chan, Sheona E. Gillies, Helen Caldwell, James A. Ross, David J. Harrison, Sandrine Prost
Pages: 889-894
Published online on: 01 December 2003

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Article

Identification of two novel tumor-associated antigens recognized by HLA-B46-restricted cytotoxic T lymphocytes

Shigeki Shichijo, Kohichi Azuma, Nobukazu Komatsu, Naoki Kawamoto, Hiroko Takedatsu, Hiroki Shomura, Hiromi Sawamizu, Yoshiaki Maeda, Masaaki Ito, Kyogo Itoh
Pages: 895-902
Published online on: 01 December 2003

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Article

Effects of prolonged cholecystokinin administration on rat pituitary-adrenocortical axis: Role of the CCK receptor subtypes 1 and 2

Ludwik K. Malendowicz, Raffaella Spinazzi, Mariola Majchrzak, Magdalena Nowak, Gastone G. Nussdorfer, Agnieszka Ziolkowska, Carlo Macchi, Marcin Trejter
Pages: 903-909
Published online on: 01 December 2003

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Review

Metabolism of D-glucose anomers in pancreatic islets (Review)

Willy J. Malaisse
Pages: 911-916
Published online on: 01 December 2003

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Review

Helicobacter pylori cytotoxin: A novel ligand for receptor-like protein tyrosine phosphatase β (Review)

Toshio Inui, Shigeto Mizuno, Kenji Takai, Masao Nakagawa, Matsumi Uchida, Mineko Fujimiya, Akihiro Asakawa, Akio Inui
Pages: 917-921
Published online on: 01 December 2003

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Article

Relationship between peroxyl radical scavenging capability measured by the chemiluminescence method and an aminocarbonyl reaction product in soy sauce

Mami Ando, Kazuki Harada, Satoshi Kitao, Makio Kobayashi, Yoshiyuki Tamura
Pages: 923-928
Published online on: 01 December 2003

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Article

Identification of a novel DNase I hypersensitive site within the far upstream region of the human HLA-DRA gene

Marina Tomassetti, Giordana Feriotto, Patrizio Giacomini, Ezio Giorda, Nicoletta Bianchi, Monica Borgatti, Alessia Finotti, Carlo Mischiati, Roberto Gambari
Pages: 929-934
Published online on: 01 December 2003

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Article

Lack of correlation between telomere length and telomerase activity and expression in leukemic cells

Danuta Januszkiewicz, Jacek Wysoki, Krzysztof Lewandowski, Monika Pernak, Karina Nowicka, Jolanta Rembowska, Jerzy Nowak
Pages: 935-938
Published online on: 01 December 2003

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Article

A novel termination codon mutation of the WAS gene in a Thai family with Wiskott-Aldrich syndrome

Pantipa Chatchatee, Chalurmpon Srichomthong, Auyporn Chewatavorn, Vorasuk Shotelersuk
Pages: 939-941
Published online on: 01 December 2003

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Article

Telomerase in intracranial meningiomas

L. Boldrini, S. Pistolesi, S. Gisfredi, S. Ursino, G. Lupi, M. Caniglia, R. Pingitore, F. Basolo, G. Parenti, G. Fontanini
Pages: 943-947
Published online on: 01 December 2003

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Article

Alteration in serum and bone component findings induced in streptozotocin-diabetic rats is restored by zinc acexamate

Satoshi Uchiyama, Masayoshi Yamaguchi
Pages: 949-954
Published online on: 01 December 2003

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Article

Manumycin induces apoptosis in human hepatocellular carcinoma HepG2 cells

Jun-Min Zhou, Xiao-Feng Zhu, Qi-Chao Pan, Duan-Fang Liao, Zhi-Ming Li, Zong-Chao Liu
Pages: 955-959
Published online on: 01 December 2003

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Article

Heparanase messenger RNA expression in epithelial ovarian tumor

Junichi Kodama, Yasuhiro Shinyo, Gaowa Hashen, Atsushi Hongo, Mitsuo Yoshinouchi, Yuji Hiramatsu
Pages: 961-964
Published online on: 01 December 2003

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Article

Immunohistochemical expression of metalloproteinases MMP-2 and MMP-9 in abdominal aortic aneurysms: Correlation with symptoms and aortic diameter

Efstathios Papalambros, Fragiska Sigala, Sotiris Georgopoulos, Charalambos Menekakos, Alexandra Giatromanolaki, Elias Bastounis, Efthymios Sivridis
Pages: 965-968
Published online on: 01 December 2003

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Article

Rare expression of target antigens for immunotherapy on disseminated tumor cells in breast cancer patients without overt metastases

Sabine Kasimir-Bauer, Friedrich Otterbach, Carsten Oberhoff, Kurt Werner Schmid, Rainer Kimmig, Siegfried Seeber
Pages: 969-975
Published online on: 01 December 2003

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Article

Expression of MMP-2 and -9 in short-term cultures of meningioma: Influence of histological subtype

Harcharan K. Rooprai, Timothy E. Van Meter, Susan D.F. Robinson, Andrew King, Garry J. Rucklidge, Geoffrey J. Pilkington
Pages: 977-981
Published online on: 01 December 2003

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Article

Molecular cloning and characterization of human RAB23, a member of the group of Rab GTPases

Irene Marcos, Salud Borrego, Guillermo Antiñolo
Pages: 983-987
Published online on: 01 December 2003

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Article

Plasma and buccal mucosal cell response to short-term supplementation with all trans-β-carotene and lycopene in human volunteers

Ram Reifen, Lior Haftel, Richard Faulks, Susan Southon, Ilana Kaplan, Betty Schwarz
Pages: 989-993
Published online on: 01 December 2003

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Article

Thrombospondin-1 induces apoptosis in primary leukemia and cell lines mediated by CD36 and Caspase-3

Karen Li, Mo Yang, Patrick Man Pan Yuen, Ki Wai Chik, Chi Kong Li, Matthew Ming Kong Shing, Hubert Kin Bong Lam, Tai Fai Fok
Pages: 995-1001
Published online on: 01 December 2003

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Article

A novel splice variant of human gene GDPD1 is mainly expressed in human ovary and small intestine

Maoqing Wu, Chaoneng Ji, Jian Xu, Xianqiong Zou, Liu Wang, Huarui Zheng, Feng Jin, Yu Wang, Shaohua Gu, Kang Ying, Yi Xie, Yumin Mao
Pages: 1003-1007
Published online on: 01 December 2003

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Article

Identification and characterization of human PPFIA4 gene in silico

Masuko Katoh, Masaru Katoh
Pages: 1009-1014
Published online on: 01 December 2003

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Article

Identification and characterization of human GRID2IP gene and rat Grid2ip gene in silico

Masuko Katoh, Masaru Katoh
Pages: 1015-1019
Published online on: 01 December 2003

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Article

Cloning and expression of the L1 major capsid protein of the human papillomavirus 18 in murine cells

Adriana Plesa, Gabriela Anton, Carmen Diaconu, Mihai Stoian, Rodica Repanovici, Costin Cernescu
Pages: 1021-1026
Published online on: 01 December 2003

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Review Open Access

Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Article Open Access

Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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Article Open Access

MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Review Open Access

Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Review Open Access

Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Article Open Access

Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Article Open Access

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Review Open Access

Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Article Open Access

Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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