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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2003 Volume 12 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2003 Volume 12 Issue 6

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Article

A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells

  • Authors:
    • Aslamuzzaman Kazi
    • Daniel A. Urbizu
    • Deborah J. Kuhn
    • Abelardo L. Acebo
    • Edward R. Jackson
    • Gail P. Greenfelder
    • Nagi B. Kumar
    • Q. Ping Dou
  • View Affiliations / Copyright

    Affiliations: Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
  • Pages: 879-887
    |
    Published online on: December 1, 2003
       https://doi.org/10.3892/ijmm.12.6.879
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Abstract

Animal studies have demonstrated that a dietary polyphenol known as tannic acid (TA) exhibits anticarcinogenic activity in chemically induced cancers. Most recently, we have reported that TA and ester-bond containing green tea polyphenols are potent proteasome inhibitors in vitro and in vivo. We hypothesize that CellQuest™, a patented formula which contains high level of TA obtained from a musaceas (plantain) plant extract, will inhibit the tumor cell proteasome activity. Here, we report that a partially purified CellQuest fraction, S3, potently inhibits the proteasomal chymotrypsin-like activity of Jurkat T cell extracts in a concentration-dependent manner. Inhibition of the proteasome by S3 in leukemia Jurkat T, simian virus 40-transformed and prostate cancer LNCaP cells results in accumulation of ubiquitinated proteins and the natural proteasome substrate p27Kip1, followed by induction of apoptosis. In contrast, non-transformed, immortalized human natural killer cells and normal human fibroblasts are resistant to S3-mediated proteasome inhibition and apoptosis induction. Our present study suggests that CellQuest targets and inhibits the proteasome selectively in tumor cells, which may contribute to the claimed anticancer activity.

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Copy and paste a formatted citation
Spandidos Publications style
Kazi A, Urbizu DA, Kuhn DJ, Acebo AL, Jackson ER, Greenfelder GP, Kumar NB and Dou QP: A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells. Int J Mol Med 12: 879-887, 2003.
APA
Kazi, A., Urbizu, D.A., Kuhn, D.J., Acebo, A.L., Jackson, E.R., Greenfelder, G.P. ... Dou, Q.P. (2003). A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells. International Journal of Molecular Medicine, 12, 879-887. https://doi.org/10.3892/ijmm.12.6.879
MLA
Kazi, A., Urbizu, D. A., Kuhn, D. J., Acebo, A. L., Jackson, E. R., Greenfelder, G. P., Kumar, N. B., Dou, Q. P."A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells". International Journal of Molecular Medicine 12.6 (2003): 879-887.
Chicago
Kazi, A., Urbizu, D. A., Kuhn, D. J., Acebo, A. L., Jackson, E. R., Greenfelder, G. P., Kumar, N. B., Dou, Q. P."A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells". International Journal of Molecular Medicine 12, no. 6 (2003): 879-887. https://doi.org/10.3892/ijmm.12.6.879
Copy and paste a formatted citation
x
Spandidos Publications style
Kazi A, Urbizu DA, Kuhn DJ, Acebo AL, Jackson ER, Greenfelder GP, Kumar NB and Dou QP: A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells. Int J Mol Med 12: 879-887, 2003.
APA
Kazi, A., Urbizu, D.A., Kuhn, D.J., Acebo, A.L., Jackson, E.R., Greenfelder, G.P. ... Dou, Q.P. (2003). A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells. International Journal of Molecular Medicine, 12, 879-887. https://doi.org/10.3892/ijmm.12.6.879
MLA
Kazi, A., Urbizu, D. A., Kuhn, D. J., Acebo, A. L., Jackson, E. R., Greenfelder, G. P., Kumar, N. B., Dou, Q. P."A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells". International Journal of Molecular Medicine 12.6 (2003): 879-887.
Chicago
Kazi, A., Urbizu, D. A., Kuhn, D. J., Acebo, A. L., Jackson, E. R., Greenfelder, G. P., Kumar, N. B., Dou, Q. P."A natural musaceas plant extract inhibits proteasome activity and induces apoptosis selectively in human tumor and transformed, but not normal and non-transformed, cells". International Journal of Molecular Medicine 12, no. 6 (2003): 879-887. https://doi.org/10.3892/ijmm.12.6.879
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