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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2004 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 13 Issue 1

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Article

Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines

  • Authors:
    • Seung Hun Jang
    • Ja Young Seol
    • Cheol Hyeon Kim
    • Chul-Gyu Yoo
    • Young Whan Kim
    • Sung Koo Han
    • Young-Soo Shim
    • Choon-Taek Lee

  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine and Lung Institute of Medical Research Center, Seoul National University College of Medicine, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea
  • Pages: 181-186
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijmm.13.1.181
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Abstract

TRAIL is a cytokine that can induce tumor-specific apoptosis through its specific death receptors (DR4 and DR5) and p53 has been proven to increase the expression of death receptors. To examine their interaction in tumor suppression, p53 and TRAIL genes were inserted in recombinant adenovirus vectors and transferred simultaneously into non-small cell lung cancer cell lines (NCI-H157, NCI-H358, NCI-H460 and A549). Western blot assay demonstrated production of TRAIL protein in NCI-H157 and A549 cell lines. Increased expressions of DR4 and DR5 of NCI-H157 and DR4 of A549 after p53 overexpression were confirmed by flow cytometry. p53 or TRAIL gene transfer increased sub-G1 fraction in cell cycle analysis and inhibited the tumor growth dose-dependently and the degree was potentiated by co-transfer. But isobologram analysis indicated an additive effect. Together, these data indicate that p53 and TRAIL interact additively on tumor apoptosis despite theoretical synergism.

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Copy and paste a formatted citation
Spandidos Publications style
Jang SH, Seol JY, Kim CH, Yoo C, Kim YW, Han SK, Shim Y and Lee C: Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines. Int J Mol Med 13: 181-186, 2004.
APA
Jang, S.H., Seol, J.Y., Kim, C.H., Yoo, C., Kim, Y.W., Han, S.K. ... Lee, C. (2004). Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines. International Journal of Molecular Medicine, 13, 181-186. https://doi.org/10.3892/ijmm.13.1.181
MLA
Jang, S. H., Seol, J. Y., Kim, C. H., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Lee, C."Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines". International Journal of Molecular Medicine 13.1 (2004): 181-186.
Chicago
Jang, S. H., Seol, J. Y., Kim, C. H., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Lee, C."Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines". International Journal of Molecular Medicine 13, no. 1 (2004): 181-186. https://doi.org/10.3892/ijmm.13.1.181
Copy and paste a formatted citation
x
Spandidos Publications style
Jang SH, Seol JY, Kim CH, Yoo C, Kim YW, Han SK, Shim Y and Lee C: Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines. Int J Mol Med 13: 181-186, 2004.
APA
Jang, S.H., Seol, J.Y., Kim, C.H., Yoo, C., Kim, Y.W., Han, S.K. ... Lee, C. (2004). Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines. International Journal of Molecular Medicine, 13, 181-186. https://doi.org/10.3892/ijmm.13.1.181
MLA
Jang, S. H., Seol, J. Y., Kim, C. H., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Lee, C."Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines". International Journal of Molecular Medicine 13.1 (2004): 181-186.
Chicago
Jang, S. H., Seol, J. Y., Kim, C. H., Yoo, C., Kim, Y. W., Han, S. K., Shim, Y., Lee, C."Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines". International Journal of Molecular Medicine 13, no. 1 (2004): 181-186. https://doi.org/10.3892/ijmm.13.1.181
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