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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
January 2004 Volume 13 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Ca2+ sensing receptor activation by CaCl2 increases [Ca2+]i resulting in enhanced spatial interactions with calbindin-D28k protein

Jai Parkash, Muhammad A. Chaudhry, William B. Rhoten
Pages: 3-11
Published online on: 01 January 2004

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Article

Chromosomal imbalances in angioleiomyomas by comparative genomic hybridization

Jun Nishio, Hiroshi Iwasaki, Yuko Ohjimi, Masako Ishiguro, Kumi Kobayashi, Kazuki Nabeshima, Masatoshi Naito, Masahiro Kikuchi
Pages: 13-16
Published online on: 01 January 2004

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Article

The pattern of gene copy number changes in bilateral breast cancer surveyed by cDNA microarray-based comparative genomic hybridization

Min Young Seo, Sun Young Rha, Sang Hwa Yang, Sang Cheol Kim, Gui Youn Lee, Chan Hee Park, Woo Ick Yang, Joong Bae Ahn, Byung Woo Park, Hyun Cheol Chung
Pages: 17-24
Published online on: 01 January 2004

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Article

Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity

Byung-Moo Min, Ju-Eun Oh, Chung-Mi Choi
Pages: 25-31
Published online on: 01 January 2004

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Article

Thyroglobulin-pulsed human monocyte-derived dendritic cells induce CD4+ T cell activation

Mariko Morishita, Kaoru Uchimaru, Katsuaki Sato, Akira Ohtsuru, Shunichi Yamashita, Takashi Kanematsu, Naohide Yamashita
Pages: 33-39
Published online on: 01 January 2004

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Article

Expression of 12-lipoxygenase in human renal cell carcinoma and growth prevention by its inhibitor

Rikio Yoshimura, Kenichiro Inoue, Yutaka Kawahito, Makoto Mitsuhashi, Kenji Tsuchida, Masahide Matsuyama, Hajime Sano, Tatsuya Nakatani
Pages: 41-46
Published online on: 01 January 2004

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Article

Hereditary multiple and isolated sporadic exostoses in the same kindred: Identification of the causative gene (EXT2) and detection of a new mutation, nt112delAT, that distinguishes the two phenotypes

Mihailo Vujic, Annika Bergman, Bertil Romanus, Jan Wahlström, Tommy Martinsson
Pages: 47-52
Published online on: 01 January 2004

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Article

Mutational analysis of the BAK gene in 192 advanced gastric and colorectal cancers

Ichiro Sakamoto, Tatsuya Yamada, Susumu Ohwada, Toru Koyama, Tetsuhiro Nakano, Toshio Okabe, Kunihiro Hamada, Susumu Kawate, Izumi Takeyoshi, Yuichi Iino, Yasuo Morishita
Pages: 53-55
Published online on: 01 January 2004

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Article

Epimorphin expression in human colonic myofibroblasts

Akira Andoh, Sanae Fujino, Yohei Hirai, Yoshihide Fujiyama
Pages: 57-61
Published online on: 01 January 2004

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Article

Increased amplification proximal to the MLL gene in acute myeloid leukemia

Ann Siew-Gek Lee, Daniel Khun-Hong Lie, Sim-Leng Tien, Christina Rudduck-Sivaswaren
Pages: 63-67
Published online on: 01 January 2004

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Article

Reactive oxygen species-producing site in radiation-induced apoptosis of human peripheral T cells: Involvement of lysosomal membrane destabilization

Yasuhiro Ogawa, Toshihiro Kobayashi, Akihito Nishioka, Shinji Kariya, Takenao Ohnishi, Shinji Hamasato, Harumichi Seguchi, Shoji Yoshida
Pages: 69-73
Published online on: 01 January 2004

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Article

Early response to interferon α treatment and long-term clinical outcome in Japanese patients with chronic HBV genotype C infection

Yasushi Seo, Seitetsu Yoon, Kenichi Hamano, Miyuki Nakaji, Yoshihiko Yano, Megumi Katayama, Toshiaki Ninomiya, Yoshitake Hayashi, Masato Kasuga
Pages: 75-79
Published online on: 01 January 2004

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Article

Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells

Hyeon G. Yoo, Sung N. Jung, Young S. Hwang, Jung S. Park, Mi H. Kim, Min Jeong, Sung J. Ahn, Bong W. Ahn, Boo A. Shin, Rae K. Park, Young D. Jung
Pages: 81-86
Published online on: 01 January 2004

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Article

Neuro-optic cell apoptosis and microangiopathy in KKAY mouse retina

Xia Ning, Qin Baoyu, Liang Yuzhen, Sheng Shuli, Eddie Reed, Qingdi Q. Li
Pages: 87-92
Published online on: 01 January 2004

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Article

Promoter methylation status of multiple genes in brain metastases of solid tumors

Pilar Gonzalez-Gomez, M. Josefa Bello, M. Eva Alonso, Cinthia Amiñoso, Isabel Lopez-Marin, Jose M. De Campos, Alberto Isla, Manuel Gutierrez, Juan A. Rey
Pages: 93-98
Published online on: 01 January 2004

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Article

TGF-β1 inhibits Fas-mediated apoptosis by regulating surface Fas and cFLIPL expression in human leukaemia/lymphoma cells

Young-Joo Jung, Jee-Youn Kim, Jae-Hoon Park
Pages: 99-104
Published online on: 01 January 2004

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Article

Edaravone, a newly developed radical scavenger, protects against ischemia-reperfusion injury of the small intestine in rats

Naoya Tomatsuri, Norimasa Yoshida, Tomohisa Takagi, Kazuhiro Katada, Yutaka Isozaki, Eiko Imamoto, Kazuhiko Uchiyama, Satoshi Kokura, Hiroshi Ichikawa, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa
Pages: 105-109
Published online on: 01 January 2004

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Article

Diverse efficacy of vaccination therapy using the α-fetoprotein gene against mouse hepatocellular carcinoma

Akira Saeki, Kazuhiko Nakao, Yuji Nagayama, Kenji Yanagi, Kojiro Matsumoto, Toshinobu Hayashi, Hiroki Ishikawa, Keisuke Hamasaki, Nobuko Ishii, Katsumi Eguchi
Pages: 111-116
Published online on: 01 January 2004

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Article

Activity of synthetic enzymes of tetrahydrobiopterin in the human placenta

Naoko Iwanaga, Sei-Ichi Yamamasu, Daisuke Tachibana, Junko Nishio, Yuichiro Nakai, Haruo Shintaku, Osamu Ishiko
Pages: 117-120
Published online on: 01 January 2004

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Article

Intracellular domain generation of amyloid precursor protein by ε-cleavage depends on C-terminal fragment by α-secretase cleavage

Hideaki Kume, Kei Maruyama, Fuyuki Kametani
Pages: 121-125
Published online on: 01 January 2004

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Article

Urinary extracellular matrix measurement as a reliable and cost effective diagnostic tool for bladder tumors

Rikio Yoshimura, Seiji Wada, Masahide Matsuyama, Taro Hase, Takeshi Goto, Tomoaki Tanaka, Katsuyuki Kuratsukuri, Kenji Tsuchida, Tatsuya Nakatani
Pages: 127-131
Published online on: 01 January 2004

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Article

Possible involvement of nuclear factor-κB inhibition in the renal protective effect of oral adsorbent AST-120 in a rat model of chronic renal failure

Toshiyuki Komiya, Katsuyuki Miura, Jin Tsukamoto, Mikio Okamura, Satoshi Tamada, Toshihiro Asai, Koichiro Tashiro, Nobuyuki Kuwabara, Hiroshi Iwao, Junichi Yoshikawa
Pages: 133-138
Published online on: 01 January 2004

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Article

Effects of leptin and leptin fragments on steroid secretion and proliferative activity of regenerating rat adrenal cortex

Anna Markowska, Giuliano Neri, Anna Hochol, Magdalena Nowak, Gastone G. Nussdorfer, Ludwik K. Malendowicz
Pages: 139-141
Published online on: 01 January 2004

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Article

EGF mediates multiple signals: dependence on the conditions

Angela R. Kamer, Peter G. Sacks, Adrian Vladutiu, Charles Liebow
Pages: 143-147
Published online on: 01 January 2004

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Article

Ethanol stimulates proliferation, ERα and aromatase expression in MCF-7 human breast cancer cells

Nicolas Etique, Dominique Chardard, Amand Chesnel, Jean-Louis Merlin, Stephane Flament, Isabelle Grillier-Vuissoz
Pages: 149-155
Published online on: 01 January 2004

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Article

Identification and characterization of human FNBP1L gene in silico

Masuko Katoh, Masaru Katoh
Pages: 157-162
Published online on: 01 January 2004

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Article

GP7 can induce apoptotic DNA fragmentation of human leukemia cells through caspase-3-dependent and -independent pathways

She-Ning Qi, Akira Yoshida, Zi-Ren Wang, Takanori Ueda
Pages: 163-167
Published online on: 01 January 2004

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Article

Gleditsia sinensis fruit extract induced growth inhibition involves basic fibroblast growth factor and nitric oxide

Chung Hin Chui, Johnny Cheuk On Tang, Fung Yi Lau, Ivy Tuang Ngo Teo, Mable Yin Chun Yau, Raymond Siu Ming Wong, Gregory Yin Ming Cheng, Stephen King Wah Ho, Thomas Wai Tong Leung, Kin Shing Hui, Mai Man Wong, Sarwat Fatima, Chor Hing Cheng, Filly Cheung, Wei Qi Tan, Larry Ming Cheung Chow, Dean Guo, Albert Sun Chi Chan
Pages: 169-173
Published online on: 01 January 2004

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Article

Surface carbohydrates as recognition determinants in non-opsonic interactions and intracellular viability of group B Streptococcus strains in murine macrophages

Georgia C.T.S. Monteiro, Raphael Hirata, Arnaldo F.B. Andrade, Ana Luiza Mattos-Guaraldi, Prescilla E. Nagao
Pages: 175-180
Published online on: 01 January 2004

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Article

Additive effect of TRAIL and p53 gene transfer on apoptosis of human lung cancer cell lines

Seung Hun Jang, Ja Young Seol, Cheol Hyeon Kim, Chul-Gyu Yoo, Young Whan Kim, Sung Koo Han, Young-Soo Shim, Choon-Taek Lee
Pages: 181-186
Published online on: 01 January 2004

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Article

Natural cell-mediated cytotoxicity of peripheral blood lymphocytes against target cells transfected with epidermodysplasia verruciformis-specific human papillomavirus type 8 L1 DNA sequences

Monika Oldak, Slawomir Majewski, Tomasz Grzela, Sabine Stark, Magdalena Malejczyk, Anna Osiecka-Iwan, Pawel G. Fuchs, Stefania Jablonska, Herbert J. Pfister, Jacek Malejczyk
Pages: 187-191
Published online on: 01 January 2004

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Article

Molecular cloning and characterization of a novel human BTBD8 gene containing double BTB/POZ domains

Jian Xu, Ti He, Liu Wang, Qihan Wu, Enpeng Zhao, Maoqing Wu, Tonghai Dou, Chaoneng Ji, Shaohua Gu, Kang Yin, Yi Xie, Yumin Mao
Pages: 193-197
Published online on: 01 January 2004

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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Article Open Access

circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Review Open Access

Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Review Open Access

Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Review Open Access

Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Review Open Access

Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Review Open Access

Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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October-2026 Volume 58 Issue 4

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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