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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2004 Volume 13 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 13 Issue 1

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Article

Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity

  • Authors:
    • Byung-Moo Min
    • Ju-Eun Oh
    • Chung-Mi Choi

  • View Affiliations / Copyright

    Affiliations: Department of Oral Biochemistry, Seoul National University College of Dentistry, Seoul 110-749, Korea. bmmin@snu.ac.kr
  • Pages: 25-31
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijmm.13.1.25
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Abstract

Retinoic acid (RA) plays an important role in the regulation of keratinocyte growth, differentiation, and senescence; however, the detailed mechanisms of RA regulation are still unclear. To investigate whether all-trans RA extends the in vitro lifespan of normal human epidermal keratinocytes (NHEKs) by affecting mitotic capacity and/or senescence, we studied the effects of all-trans RA on cell growth, senescence, the expression of βig-h3 and Rb cell cycle regulators, and the telomerase activity of NHEKs after RA exposure. When primary NHEKs were cultured in medium containing 1 nM of all-trans RA, the proliferation and replicative senescence of the cells was significantly stimulated and inhibited, respectively, and the in vitro lifespan of the cells increased 1.4- to 1.5-fold compared to the vehicle control. The levels of βig-h3 and p16 in 1 nM of RA-treated cells remained significantly lower than that of the vehicle control at all population doublings. All-trans RA also triggered induction of telomerase activity in NHEKs with increasing a population doublings induced by RA treatment. These results support that the ability of all-trans RA to postpone, but not prevent, senescence may be related to both partial inhibition of p16 and βig-h3 expression and induction of telomerase activity.

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Copy and paste a formatted citation
Spandidos Publications style
Min B, Oh J and Choi C: Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity. Int J Mol Med 13: 25-31, 2004.
APA
Min, B., Oh, J., & Choi, C. (2004). Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity. International Journal of Molecular Medicine, 13, 25-31. https://doi.org/10.3892/ijmm.13.1.25
MLA
Min, B., Oh, J., Choi, C."Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity". International Journal of Molecular Medicine 13.1 (2004): 25-31.
Chicago
Min, B., Oh, J., Choi, C."Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity". International Journal of Molecular Medicine 13, no. 1 (2004): 25-31. https://doi.org/10.3892/ijmm.13.1.25
Copy and paste a formatted citation
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Spandidos Publications style
Min B, Oh J and Choi C: Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity. Int J Mol Med 13: 25-31, 2004.
APA
Min, B., Oh, J., & Choi, C. (2004). Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity. International Journal of Molecular Medicine, 13, 25-31. https://doi.org/10.3892/ijmm.13.1.25
MLA
Min, B., Oh, J., Choi, C."Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity". International Journal of Molecular Medicine 13.1 (2004): 25-31.
Chicago
Min, B., Oh, J., Choi, C."Retinoic acid delays keratinocyte senescence by suppression of βig-h3 and p16 expression and induction of telomerase activity". International Journal of Molecular Medicine 13, no. 1 (2004): 25-31. https://doi.org/10.3892/ijmm.13.1.25
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