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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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January 2004 Volume 13 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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January 2004 Volume 13 Issue 1

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Article

Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells

  • Authors:
    • Hyeon G. Yoo
    • Sung N. Jung
    • Young S. Hwang
    • Jung S. Park
    • Mi H. Kim
    • Min Jeong
    • Sung J. Ahn
    • Bong W. Ahn
    • Boo A. Shin
    • Rae K. Park
    • Young D. Jung

  • View Affiliations / Copyright

    Affiliations: Chonnam University Research Institute of Medical Sciences, Chonnam National University Medical School, Kwangju, Korea
  • Pages: 81-86
    |
    Published online on: January 1, 2004
       https://doi.org/10.3892/ijmm.13.1.81
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Abstract

Silibinin, the flavonoid found in the milk thistle, has been shown to suppress cell growth and exhibit anti-cancer effects. Some flavonoids were reported to inhibit angiogenesis which is essential for tumor growth and metastasis. In this study, to clarify the underlying mechanisms for the anti-cancer effect of silibinin, we examined the effects of silibinin on human endothelial ECV304 cells. Silibinin was found to suppress the growth and induce the apoptosis of ECV304 cells. The induction of apoptosis by silibinin was confirmed by ladder-patterned DNA fragmentation, cleaved and condensed nuclear chromatin and DNA hypoploidy. Silibinin could effectively inhibit constitutive NF-κB activation as revealed by electrophoretic mobility shift assay and NF-κB-dependent luciferase reporter study. Consistent with this, silibinin treatment resulted in a significant decrease in the nuclear level of p65 subunit of NF-κB. In addition, silibinin treatment caused a change in the ratio of Bax/Bcl-2 in a manner that favors apoptosis. Silibinin also induced the cytochrome c release, activation of caspase-3 and caspase-9 and cleavage of PARP. These results suggest that silibinin may exert, at least partly, its anti-cancer effect by inhibiting angiogenesis through induction of endothelial apoptosis via modulation of NF-κB, Bcl-2 family and caspases.

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Copy and paste a formatted citation
Spandidos Publications style
Yoo HG, Jung SN, Hwang YS, Park JS, Kim MH, Jeong M, Ahn SJ, Ahn BW, Shin BA, Park RK, Park RK, et al: Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells. Int J Mol Med 13: 81-86, 2004.
APA
Yoo, H.G., Jung, S.N., Hwang, Y.S., Park, J.S., Kim, M.H., Jeong, M. ... Jung, Y.D. (2004). Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells. International Journal of Molecular Medicine, 13, 81-86. https://doi.org/10.3892/ijmm.13.1.81
MLA
Yoo, H. G., Jung, S. N., Hwang, Y. S., Park, J. S., Kim, M. H., Jeong, M., Ahn, S. J., Ahn, B. W., Shin, B. A., Park, R. K., Jung, Y. D."Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells". International Journal of Molecular Medicine 13.1 (2004): 81-86.
Chicago
Yoo, H. G., Jung, S. N., Hwang, Y. S., Park, J. S., Kim, M. H., Jeong, M., Ahn, S. J., Ahn, B. W., Shin, B. A., Park, R. K., Jung, Y. D."Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells". International Journal of Molecular Medicine 13, no. 1 (2004): 81-86. https://doi.org/10.3892/ijmm.13.1.81
Copy and paste a formatted citation
x
Spandidos Publications style
Yoo HG, Jung SN, Hwang YS, Park JS, Kim MH, Jeong M, Ahn SJ, Ahn BW, Shin BA, Park RK, Park RK, et al: Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells. Int J Mol Med 13: 81-86, 2004.
APA
Yoo, H.G., Jung, S.N., Hwang, Y.S., Park, J.S., Kim, M.H., Jeong, M. ... Jung, Y.D. (2004). Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells. International Journal of Molecular Medicine, 13, 81-86. https://doi.org/10.3892/ijmm.13.1.81
MLA
Yoo, H. G., Jung, S. N., Hwang, Y. S., Park, J. S., Kim, M. H., Jeong, M., Ahn, S. J., Ahn, B. W., Shin, B. A., Park, R. K., Jung, Y. D."Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells". International Journal of Molecular Medicine 13.1 (2004): 81-86.
Chicago
Yoo, H. G., Jung, S. N., Hwang, Y. S., Park, J. S., Kim, M. H., Jeong, M., Ahn, S. J., Ahn, B. W., Shin, B. A., Park, R. K., Jung, Y. D."Involvement of NF-κB and caspases in silibinin-induced apoptosis of endothelial cells". International Journal of Molecular Medicine 13, no. 1 (2004): 81-86. https://doi.org/10.3892/ijmm.13.1.81
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