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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2004 Volume 13 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2004 Volume 13 Issue 2

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Article

Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines

  • Authors:
    • Alejandro J. Español
    • María E. Sales

  • View Affiliations / Copyright

    Affiliations: Departamento de Inmunobiología, Area Investigación, Instituto de Oncología Angel H. Roffo, Universidad de Buenos Aires, CP 1417, Buenos Aires, Argentina
  • Pages: 311-317
    |
    Published online on: February 1, 2004
       https://doi.org/10.3892/ijmm.13.2.311
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Abstract

We described that two different murine mammary adenocarcinoma cell lines, LM3 and LM2 constitutively expressed muscarinic acetylcholine receptors (mAchR). We here demonstrate, by competitive binding experiments with the tritiated muscarinic antagonist quinuclidinyl benzilate that M2 subtype predominates in both tumor cell lines. Concordantly immunoblotting assays indicate that mAchR exhibit the following order of expression: M2 > M4 > M3 > M1 >> M5 in both tumor cell lines. Activation of mAchR with carbachol (CARB) increased proliferation in both tumor cell lines in a concentration dependent manner. In LM3 cells CARB promoted proliferation via M3 receptor activation via inositol 1,4,5-triphosphate and nitric oxide production. CARB-induced LM2 cells proliferation needed both M2 and M1 receptor activation, promoting prostaglandin E2 liberation and arginase catabolism respectively, both of them involved in tumor cell growth.

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Copy and paste a formatted citation
Spandidos Publications style
Español AJ and Sales ME: Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. Int J Mol Med 13: 311-317, 2004.
APA
Español, A.J., & Sales, M.E. (2004). Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. International Journal of Molecular Medicine, 13, 311-317. https://doi.org/10.3892/ijmm.13.2.311
MLA
Español, A. J., Sales, M. E."Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines". International Journal of Molecular Medicine 13.2 (2004): 311-317.
Chicago
Español, A. J., Sales, M. E."Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines". International Journal of Molecular Medicine 13, no. 2 (2004): 311-317. https://doi.org/10.3892/ijmm.13.2.311
Copy and paste a formatted citation
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Spandidos Publications style
Español AJ and Sales ME: Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. Int J Mol Med 13: 311-317, 2004.
APA
Español, A.J., & Sales, M.E. (2004). Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines. International Journal of Molecular Medicine, 13, 311-317. https://doi.org/10.3892/ijmm.13.2.311
MLA
Español, A. J., Sales, M. E."Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines". International Journal of Molecular Medicine 13.2 (2004): 311-317.
Chicago
Español, A. J., Sales, M. E."Different muscarinc receptors are involved in the proliferation of murine mammary adenocarcinoma cell lines". International Journal of Molecular Medicine 13, no. 2 (2004): 311-317. https://doi.org/10.3892/ijmm.13.2.311
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