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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
March 2004 Volume 13 Issue 3

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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March 2004 Volume 13 Issue 3

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Article

Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells

  • Authors:
    • Hong-Lok Lung
    • Wai-Ki Ip
    • Zhen-Yu Chen
    • Nai-Ki Mak
    • Kwok-Nam Leung

  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry, The Chinese University of Hong Kong, Shatin, China
  • Pages: 465-471
    |
    Published online on: March 1, 2004
       https://doi.org/10.3892/ijmm.13.3.465
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Abstract

Among the black tea polyphenols, theaflavins are generally considered to be the more effective components for the inhibition of carcinogenesis. In this study, we attempted to compare the growth-inhibitory and apoptosis-inducing activities of the four black tea theaflavins (TF-1, TF-2A, TF-2B and TF-3) with the major green tea catechin epigallocatechin-3-gallate (EGCG) on the murine myeloid leukemia WEHI-3B JCS cells. All the four black tea theaflavins were shown to exert potent anti-proliferative and cytotoxic effects on the leukemia WEHI-3B JCS cells in a dose-dependent manner. The observed anti-proliferative and cytotoxic effects were in the following order of potency: EGCG > TF-2B > TF-3 > TF-2A > TF-1. In addition, all theaflavins were capable of inducing apoptosis in the leukemia WEHI-3B JCS cells. Among the four theaflavins tested, TF-2B and TF-3 were found to be slightly more potent in inducing apoptosis of the WEHI-3B JCS cells than that of TF-2A and TF-1 but were comparable to the major green tea epicatechin EGCG. More interestingly, both TF-2B and TF-3 were found to be much more effective than TF-1 and TF-2B in reducing both the in vitro clonogenicity and in vivo tumorigenicity of the WEHI-3B JCS cells, suggesting that these two black tea theaflavins might represent potential candidates for the treatment of some forms of leukemia.

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Copy and paste a formatted citation
Spandidos Publications style
Lung H, Ip W, Chen Z, Mak N and Leung K: Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. Int J Mol Med 13: 465-471, 2004.
APA
Lung, H., Ip, W., Chen, Z., Mak, N., & Leung, K. (2004). Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. International Journal of Molecular Medicine, 13, 465-471. https://doi.org/10.3892/ijmm.13.3.465
MLA
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13.3 (2004): 465-471.
Chicago
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13, no. 3 (2004): 465-471. https://doi.org/10.3892/ijmm.13.3.465
Copy and paste a formatted citation
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Spandidos Publications style
Lung H, Ip W, Chen Z, Mak N and Leung K: Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. Int J Mol Med 13: 465-471, 2004.
APA
Lung, H., Ip, W., Chen, Z., Mak, N., & Leung, K. (2004). Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells. International Journal of Molecular Medicine, 13, 465-471. https://doi.org/10.3892/ijmm.13.3.465
MLA
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13.3 (2004): 465-471.
Chicago
Lung, H., Ip, W., Chen, Z., Mak, N., Leung, K."Comparative study of the growth-inhibitory and apoptosis-inducing activities of black tea theaflavins and green tea catechin on murine myeloid leukemia cells". International Journal of Molecular Medicine 13, no. 3 (2004): 465-471. https://doi.org/10.3892/ijmm.13.3.465
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