The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation

  • Authors:
    • Toshiaki Takahashi
    • Yasuhiro Ogawa
    • Toshihiro Kobayashi
    • Hiroshi Sonobe
    • Harumichi Seguchi
    • Toshikazu Tani
    • Shoji Yoshida
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/ijmm.13.5.661
  • Pages: 661-664
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Abstract

Selective inhibition of COX-2 is thought to prevent carcinogenesis in some malignant tumors. In this study, in an effort to enhance the effectiveness of osteosarcoma treatment, we investigated the effect of a selective inhibitor of COX-2, with or without irradiation. We also asked whether selective COX-2 inhibitors increase the effect of X-ray irradiation, with regard to reactive oxygen species (ROS) formation in an osteosarcoma cell line. Our results showed that the presence of COX-2 inhibitor without irradiation results in faint spots of ROS formation that do not appear in the absence of COX-2 inhibitor. However, COX-2 inhibitor did not induce ROS formation when combined with irradiation. Thus, radiotherapy with selective COX-2 inhibitions has limitations in the treatment of radioresistant osteosarcoma to obtain the effective achievement, it is indispensable to combine another agent in future studies.

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May 2004
Volume 13 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Takahashi T, Ogawa Y, Kobayashi T, Sonobe H, Seguchi H, Tani T and Yoshida S: The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. Int J Mol Med 13: 661-664, 2004
APA
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., & Yoshida, S. (2004). The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation. International Journal of Molecular Medicine, 13, 661-664. https://doi.org/10.3892/ijmm.13.5.661
MLA
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., Yoshida, S."The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation". International Journal of Molecular Medicine 13.5 (2004): 661-664.
Chicago
Takahashi, T., Ogawa, Y., Kobayashi, T., Sonobe, H., Seguchi, H., Tani, T., Yoshida, S."The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiation". International Journal of Molecular Medicine 13, no. 5 (2004): 661-664. https://doi.org/10.3892/ijmm.13.5.661