The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-κB activation in human hepatoma cell line and rat liver

  • Authors:
    • Sang Hoon Hong
    • Sang Ho Seo
    • Jun Hyuk Lee
    • Byung Tae Choi
  • View Affiliations

  • Published online on: May 1, 2004     https://doi.org/10.3892/ijmm.13.5.717
  • Pages: 717-720
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Artemisia capillaris Thunb. has been used for the remedy of liver diseases such as hepatitis, jaundice and fatty liver in traditional oriental medicine. However, despite extensive pharmacological studies, the molecular mechanism of the anti-inflammatory effect of Artemisia capillaris Thunb. has hardly been studied. In the present study, we investigated the pharmacological action mechanism on LPS-induced liver inflammation in HepG2 human hepatocarcinoma cells and rat liver. Aqueous extract from Artemisia capillaris Thunb. (AEAC) inhibits expression of inflammatory proteins including iNOS, COX-2 and TNF-α. Also, nuclear translocation of NF-κB and degradation of I-κBα are blocked by AEAC pretreatment. These results suggest that the inhibitory effect of AEAC on the expression of inflammatory proteins involves suppression of NF-κB activation.

Related Articles

Journal Cover

May 2004
Volume 13 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hong SH, Seo SH, Lee JH and Choi BT: The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-κB activation in human hepatoma cell line and rat liver. Int J Mol Med 13: 717-720, 2004.
APA
Hong, S.H., Seo, S.H., Lee, J.H., & Choi, B.T. (2004). The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-κB activation in human hepatoma cell line and rat liver. International Journal of Molecular Medicine, 13, 717-720. https://doi.org/10.3892/ijmm.13.5.717
MLA
Hong, S. H., Seo, S. H., Lee, J. H., Choi, B. T."The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-κB activation in human hepatoma cell line and rat liver". International Journal of Molecular Medicine 13.5 (2004): 717-720.
Chicago
Hong, S. H., Seo, S. H., Lee, J. H., Choi, B. T."The aqueous extract from Artemisia capillaris Thunb. inhibits lipopolysaccharide-induced inflammatory response through preventing NF-κB activation in human hepatoma cell line and rat liver". International Journal of Molecular Medicine 13, no. 5 (2004): 717-720. https://doi.org/10.3892/ijmm.13.5.717