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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2004 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 13 Issue 6

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Article

Helicobacter pylori induces chronic active gastritis in p53-knockout mice

  • Authors:
    • Junko Nagata
    • Hiroshi Kijima
    • Atsushi Takagi
    • Mamoru Ito
    • Kazuo Goto
    • Hitoshi Yamazaki
    • Masato Nakamura
    • Tetsuya Mine
    • Yoshito Ueyama

  • View Affiliations / Copyright

    Affiliations: Departments of Pathology and Gastroenterology, Tokai University School of Medicine, Bohseidai, Isehara-shi, Kanagawa 259-1193, Japan
  • Pages: 773-777
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijmm.13.6.773
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Abstract

Gastritis and peptic ulcers result from Helicobacter pylori (H. pylori) infection. To analyze the influence of Helicobacter on inflammatory responses and cell proliferation, we used an animal model of H. pylori-induced gastritis in p53-knockout mice. H. pylori were introduced by gastric intubation into p53-knockout C57BL/6 mice. The animals were then followed-up for 1 year and compared with uninfected controls of the same genotype. Serum levels of anti-H. pylori antibody and histopathological changes were analyzed according to the updated Sydney System. Immunohistochemistry for proliferating cell nuclear antigen (PCNA) and TUNEL staining were also performed. The infected mice showed significantly increased levels of anti-H. pylori antibody in serum. Histologically, p53-knockout mice exhibited increased scores of chronic and active inflammation compared with uninfected controls. The PCNA and TUNEL indices were 25.5% and 10/mm, respectively, in the inflammatory foci of infected mice, and were increased compared with the controls. In the p53-knockout mice, H. pylori infection caused severe inflammatory reactions. The p53 gene may play an important role in inflammatory responses including cell proliferation and apoptosis.

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Copy and paste a formatted citation
Spandidos Publications style
Nagata J, Kijima H, Takagi A, Ito M, Goto K, Yamazaki H, Nakamura M, Mine T and Ueyama Y: Helicobacter pylori induces chronic active gastritis in p53-knockout mice. Int J Mol Med 13: 773-777, 2004.
APA
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H. ... Ueyama, Y. (2004). Helicobacter pylori induces chronic active gastritis in p53-knockout mice. International Journal of Molecular Medicine, 13, 773-777. https://doi.org/10.3892/ijmm.13.6.773
MLA
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H., Nakamura, M., Mine, T., Ueyama, Y."Helicobacter pylori induces chronic active gastritis in p53-knockout mice". International Journal of Molecular Medicine 13.6 (2004): 773-777.
Chicago
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H., Nakamura, M., Mine, T., Ueyama, Y."Helicobacter pylori induces chronic active gastritis in p53-knockout mice". International Journal of Molecular Medicine 13, no. 6 (2004): 773-777. https://doi.org/10.3892/ijmm.13.6.773
Copy and paste a formatted citation
x
Spandidos Publications style
Nagata J, Kijima H, Takagi A, Ito M, Goto K, Yamazaki H, Nakamura M, Mine T and Ueyama Y: Helicobacter pylori induces chronic active gastritis in p53-knockout mice. Int J Mol Med 13: 773-777, 2004.
APA
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H. ... Ueyama, Y. (2004). Helicobacter pylori induces chronic active gastritis in p53-knockout mice. International Journal of Molecular Medicine, 13, 773-777. https://doi.org/10.3892/ijmm.13.6.773
MLA
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H., Nakamura, M., Mine, T., Ueyama, Y."Helicobacter pylori induces chronic active gastritis in p53-knockout mice". International Journal of Molecular Medicine 13.6 (2004): 773-777.
Chicago
Nagata, J., Kijima, H., Takagi, A., Ito, M., Goto, K., Yamazaki, H., Nakamura, M., Mine, T., Ueyama, Y."Helicobacter pylori induces chronic active gastritis in p53-knockout mice". International Journal of Molecular Medicine 13, no. 6 (2004): 773-777. https://doi.org/10.3892/ijmm.13.6.773
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