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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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June 2004 Volume 13 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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June 2004 Volume 13 Issue 6

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Article

Degradation of wheat allergen in Japanese soy sauce

  • Authors:
    • Makio Kobayashi
    • Yuichiro Hashimoto
    • Shoichiro Taniuchi
    • Soichi Tanabe

  • View Affiliations / Copyright

    Affiliations: Research Laboratory, Higashimaru Shoyu Co. Ltd., Tatsuno-cho, Tatsuno, Hyogo 679-4167, Japan. mkobayashi@higashimaru.co.jp
  • Pages: 821-827
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijmm.13.6.821
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Abstract

Soy sauce is a traditional fermented seasoning of East Asian countries and is available throughout the world. Wheat and soybeans are the 2 main raw materials of soy sauce, and soy sauce also contains a high concentration of salt. Since wheat allergy is considered a serious problem globally, it is significant to examine the allergenicity of soy sauce. In this study, by immunoblotting, inhibition ELISA and direct ELISA using sera from 5 children with wheat allergy, it was clearly demonstrated that wheat allergens were degraded into amino acids and peptides losing the IgE-binding ability in both salt-soluble and salt-insoluble fractions of soy sauce during fermentation. Furthermore, no wheat allergen was detected in 10 items of commercial soy sauce in Japan, by inhibition ELISA or direct ELISA using the sera of patients. In the brewing process of soy sauce, first salt-insoluble wheat allergen was solubilized to salt water during the koji stage (mold cultivation and enzyme production), and second both the resultant salt-solubilized and initially salt-soluble wheat allergens were completely degraded during the moromi stage (fermentation) by microbial proteolytic enzymes. Therefore, it was concluded that no wheat allergen is contained in soy sauce.

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Copy and paste a formatted citation
Spandidos Publications style
Kobayashi M, Hashimoto Y, Taniuchi S and Tanabe S: Degradation of wheat allergen in Japanese soy sauce. Int J Mol Med 13: 821-827, 2004.
APA
Kobayashi, M., Hashimoto, Y., Taniuchi, S., & Tanabe, S. (2004). Degradation of wheat allergen in Japanese soy sauce. International Journal of Molecular Medicine, 13, 821-827. https://doi.org/10.3892/ijmm.13.6.821
MLA
Kobayashi, M., Hashimoto, Y., Taniuchi, S., Tanabe, S."Degradation of wheat allergen in Japanese soy sauce". International Journal of Molecular Medicine 13.6 (2004): 821-827.
Chicago
Kobayashi, M., Hashimoto, Y., Taniuchi, S., Tanabe, S."Degradation of wheat allergen in Japanese soy sauce". International Journal of Molecular Medicine 13, no. 6 (2004): 821-827. https://doi.org/10.3892/ijmm.13.6.821
Copy and paste a formatted citation
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Spandidos Publications style
Kobayashi M, Hashimoto Y, Taniuchi S and Tanabe S: Degradation of wheat allergen in Japanese soy sauce. Int J Mol Med 13: 821-827, 2004.
APA
Kobayashi, M., Hashimoto, Y., Taniuchi, S., & Tanabe, S. (2004). Degradation of wheat allergen in Japanese soy sauce. International Journal of Molecular Medicine, 13, 821-827. https://doi.org/10.3892/ijmm.13.6.821
MLA
Kobayashi, M., Hashimoto, Y., Taniuchi, S., Tanabe, S."Degradation of wheat allergen in Japanese soy sauce". International Journal of Molecular Medicine 13.6 (2004): 821-827.
Chicago
Kobayashi, M., Hashimoto, Y., Taniuchi, S., Tanabe, S."Degradation of wheat allergen in Japanese soy sauce". International Journal of Molecular Medicine 13, no. 6 (2004): 821-827. https://doi.org/10.3892/ijmm.13.6.821
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