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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
June 2004 Volume 13 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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June 2004 Volume 13 Issue 6

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Article

Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines

  • Authors:
    • Toshihiro Murata
    • Minoru Haisa
    • Hirokazu Uetsuka
    • Tetuji Nobuhisa
    • Takaomi Ookawa
    • Yoko Tabuchi
    • Yasuaki Shirakawa
    • Tomoki Yamatsuji
    • Junji Matsuoka
    • Masahiko Nishiyama
    • Noriaki Tanaka
    • Yoshio Naomoto

  • View Affiliations / Copyright

    Affiliations: Departments of Gastroenterological Surgery, Transplant, and Surgical Oncology, Okayama University, Okayama 700-8558, Japan
  • Pages: 865-868
    |
    Published online on: June 1, 2004
       https://doi.org/10.3892/ijmm.13.6.865
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Abstract

It is important to clarify the mechanism of resistance to cisplatin for the treatment of solid tumors. We have examined the expression of apoptosis-related proteins, Bax and Bcl-2, in ovarian cancer cells. We used the cell line 2008 and its cisplatin resistant subclone 2008 C-13. The percentage of 2008 cells showing apoptosis was significantly higher following cisplatin treatment as compared to untreated controls. 2008 C-13 cells showing apoptosis did not differ between the cisplatin-treated group and the untreated group. The expression of mRNA and protein of Bax in the two cell lines were not altered by treatment with cisplatin. Although the expression of mRNA and protein of Bcl-2 decreased in 2008 cells after treatment with cisplatin, the expression of Bcl-2 remained unchanged in 2008 C-13 cells. Our results indicate that the down-regulation of Bcl-2 plays an important role in the mechanisms of tumor resistance to anticancer drugs.

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Copy and paste a formatted citation
Spandidos Publications style
Murata T, Haisa M, Uetsuka H, Nobuhisa T, Ookawa T, Tabuchi Y, Shirakawa Y, Yamatsuji T, Matsuoka J, Nishiyama M, Nishiyama M, et al: Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. Int J Mol Med 13: 865-868, 2004.
APA
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y. ... Naomoto, Y. (2004). Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. International Journal of Molecular Medicine, 13, 865-868. https://doi.org/10.3892/ijmm.13.6.865
MLA
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Nishiyama, M., Tanaka, N., Naomoto, Y."Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines". International Journal of Molecular Medicine 13.6 (2004): 865-868.
Chicago
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Nishiyama, M., Tanaka, N., Naomoto, Y."Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines". International Journal of Molecular Medicine 13, no. 6 (2004): 865-868. https://doi.org/10.3892/ijmm.13.6.865
Copy and paste a formatted citation
x
Spandidos Publications style
Murata T, Haisa M, Uetsuka H, Nobuhisa T, Ookawa T, Tabuchi Y, Shirakawa Y, Yamatsuji T, Matsuoka J, Nishiyama M, Nishiyama M, et al: Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. Int J Mol Med 13: 865-868, 2004.
APA
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y. ... Naomoto, Y. (2004). Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines. International Journal of Molecular Medicine, 13, 865-868. https://doi.org/10.3892/ijmm.13.6.865
MLA
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Nishiyama, M., Tanaka, N., Naomoto, Y."Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines". International Journal of Molecular Medicine 13.6 (2004): 865-868.
Chicago
Murata, T., Haisa, M., Uetsuka, H., Nobuhisa, T., Ookawa, T., Tabuchi, Y., Shirakawa, Y., Yamatsuji, T., Matsuoka, J., Nishiyama, M., Tanaka, N., Naomoto, Y."Molecular mechanism of chemoresistance to cisplatin in ovarian cancer cell lines". International Journal of Molecular Medicine 13, no. 6 (2004): 865-868. https://doi.org/10.3892/ijmm.13.6.865
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