Mitochondrial impairment induces excitotoxic death in cerebellar granule cells

  • Authors:
    • Antonella Bobba
    • Anna Atlante
    • Amalia Azzariti
    • Giuseppe Sgaramella
    • Pietro Calissano
    • Ersilia Marra
  • View Affiliations

  • Published online on: June 1, 2004     https://doi.org/10.3892/ijmm.13.6.873
  • Pages: 873-876
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

A close relationship links mitochondria to cell death with mitochondrial function-impairment considered a major biochemical event in the process of both apoptosis and necrosis. We have used different inhibitors of oxidative phosphorylation, i.e. mitochondrial respiratory chain and ATP synthesis inhibitors, and an uncoupler to investigate the mode of cell death caused by these compounds in cerebellar granule cells. This study shows that in cultured cerebellar granule cells either oxidative phosphorylation inhibitors or uncoupler induce an excitotoxic-like reaction which is mediated by activation of NMDA receptors and is likely due to the release of glutamate. Consistently, survival may occur if the toxic action of glutamate is prevented.

Related Articles

Journal Cover

June 2004
Volume 13 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Bobba A, Atlante A, Azzariti A, Sgaramella G, Calissano P and Marra E: Mitochondrial impairment induces excitotoxic death in cerebellar granule cells. Int J Mol Med 13: 873-876, 2004
APA
Bobba, A., Atlante, A., Azzariti, A., Sgaramella, G., Calissano, P., & Marra, E. (2004). Mitochondrial impairment induces excitotoxic death in cerebellar granule cells. International Journal of Molecular Medicine, 13, 873-876. https://doi.org/10.3892/ijmm.13.6.873
MLA
Bobba, A., Atlante, A., Azzariti, A., Sgaramella, G., Calissano, P., Marra, E."Mitochondrial impairment induces excitotoxic death in cerebellar granule cells". International Journal of Molecular Medicine 13.6 (2004): 873-876.
Chicago
Bobba, A., Atlante, A., Azzariti, A., Sgaramella, G., Calissano, P., Marra, E."Mitochondrial impairment induces excitotoxic death in cerebellar granule cells". International Journal of Molecular Medicine 13, no. 6 (2004): 873-876. https://doi.org/10.3892/ijmm.13.6.873