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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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October 2004 Volume 14 Issue 1

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 1

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Article

Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis

  • Authors:
    • Khaled A. Rmali
    • Mahir A.A. Al-Rawi
    • Christian Parr
    • Malcolm C.A. Puntis
    • Wen G. Jiang

  • View Affiliations / Copyright

    Affiliations: Metastasis and Angiogenesis Research Group, University Department of Surgery, University of Wales College of Medicine, Heath Park, Cardiff, CF14 4XN, UK. rmali@cf.ac.uk
  • Pages: 75-80
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.1.75
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Abstract

Tumour endothelial marker-8 (TEM-8) has been found to be selectively upregulated in tumour-associated endothelial cells and is implicated in tumour specific angiogenesis. Specific factors, indigenous to tissues and tumours that regulate the TEM-8 mechanism in angiogenesis are not defined. We report for the first time that interleukin-1β induces the expression of TEM-8 in endothelial cells. Human vascular endothelial cells (HECV), which strongly express IL-1β receptor (as revealed by RT-PCR, Western blotting), increased the level of TEM-8 expression following stimulation with IL-1β (as revealed by conventional and quantitative RT-PCR). Using a newly developed antibody to human TEM-8, we have further demonstrated that IL-1β significantly raised the level of TEM-8 at the protein level, as revealed by Western blotting. In vitro tubule forming assay, revealed that IL-1β significantly induced the formation of capillary-like tubules from the HECV cells, accompanied by an increase in TEM-8 expression. It is concluded that IL-1β is a powerful regulator of the expression of TEM-8 in vascular endothelial cells. Our results suggest an important pathway through which IL-1β regulates tumour-associated angiogenesis.

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Copy and paste a formatted citation
Spandidos Publications style
Rmali KA, Al-Rawi MA, Parr C, Puntis MC and Jiang WG: Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis. Int J Mol Med 14: 75-80, 2004.
APA
Rmali, K.A., Al-Rawi, M.A., Parr, C., Puntis, M.C., & Jiang, W.G. (2004). Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis. International Journal of Molecular Medicine, 14, 75-80. https://doi.org/10.3892/ijmm.14.1.75
MLA
Rmali, K. A., Al-Rawi, M. A., Parr, C., Puntis, M. C., Jiang, W. G."Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis". International Journal of Molecular Medicine 14.1 (2004): 75-80.
Chicago
Rmali, K. A., Al-Rawi, M. A., Parr, C., Puntis, M. C., Jiang, W. G."Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis". International Journal of Molecular Medicine 14, no. 1 (2004): 75-80. https://doi.org/10.3892/ijmm.14.1.75
Copy and paste a formatted citation
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Spandidos Publications style
Rmali KA, Al-Rawi MA, Parr C, Puntis MC and Jiang WG: Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis. Int J Mol Med 14: 75-80, 2004.
APA
Rmali, K.A., Al-Rawi, M.A., Parr, C., Puntis, M.C., & Jiang, W.G. (2004). Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis. International Journal of Molecular Medicine, 14, 75-80. https://doi.org/10.3892/ijmm.14.1.75
MLA
Rmali, K. A., Al-Rawi, M. A., Parr, C., Puntis, M. C., Jiang, W. G."Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis". International Journal of Molecular Medicine 14.1 (2004): 75-80.
Chicago
Rmali, K. A., Al-Rawi, M. A., Parr, C., Puntis, M. C., Jiang, W. G."Upregulation of tumour endothelial marker-8 by interleukin-1β and its impact in IL-1β induced angiogenesis". International Journal of Molecular Medicine 14, no. 1 (2004): 75-80. https://doi.org/10.3892/ijmm.14.1.75
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