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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro

  • Authors:
    • Anna S. Belloni
    • Carlo Macchi
    • Piera Rebuffat
    • Maria Teresa Conconi
    • Ludwik K. Malendowicz
    • Pier Paolo Parnigotto
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Departmen of Human Anatomy and Physiology, Section of Anatomy, University of Padua, I-35121 Padua, Italy
  • Pages: 165-167
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.165
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Abstract

Evidence indicates that ghrelin, an endogenous ligand of the growth hormone secretagogue receptor, controls the growth of several human and rat cell types cultured in vitro. Hence, we have investigated, by using both TUNEL and ELISA assays, the effects of 10−8 M ghrelin on the basal apoptotic deletion rate of rat osteoblasts and thymocytes, rat and human adrenocortical cells, human umbilical vein endothelial cells, and human aldosteronoma cells cultured in vitro, as well as of the human adrenocortical carcinoma-derived cell lines NCI-H295 and SW-13. Both assays consistently showed that ghrelin did not affect apoptotic rate of normal rat and human cells, but significantly enhanced apoptotic deletion in aldosteronoma, NCI-H295 and SW-13 cell cultures. Due to the central role of apoptosis in the control of tumor growth, these findings, if confirmed in other tumor cell types, could suggest an antitumoral action of ghrelin.

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Copy and paste a formatted citation
Spandidos Publications style
Belloni AS, Macchi C, Rebuffat P, Conconi MT, Malendowicz LK, Parnigotto PP and Nussdorfer GG: Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro. Int J Mol Med 14: 165-167, 2004.
APA
Belloni, A.S., Macchi, C., Rebuffat, P., Conconi, M.T., Malendowicz, L.K., Parnigotto, P.P., & Nussdorfer, G.G. (2004). Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro. International Journal of Molecular Medicine, 14, 165-167. https://doi.org/10.3892/ijmm.14.2.165
MLA
Belloni, A. S., Macchi, C., Rebuffat, P., Conconi, M. T., Malendowicz, L. K., Parnigotto, P. P., Nussdorfer, G. G."Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro". International Journal of Molecular Medicine 14.2 (2004): 165-167.
Chicago
Belloni, A. S., Macchi, C., Rebuffat, P., Conconi, M. T., Malendowicz, L. K., Parnigotto, P. P., Nussdorfer, G. G."Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro". International Journal of Molecular Medicine 14, no. 2 (2004): 165-167. https://doi.org/10.3892/ijmm.14.2.165
Copy and paste a formatted citation
x
Spandidos Publications style
Belloni AS, Macchi C, Rebuffat P, Conconi MT, Malendowicz LK, Parnigotto PP and Nussdorfer GG: Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro. Int J Mol Med 14: 165-167, 2004.
APA
Belloni, A.S., Macchi, C., Rebuffat, P., Conconi, M.T., Malendowicz, L.K., Parnigotto, P.P., & Nussdorfer, G.G. (2004). Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro. International Journal of Molecular Medicine, 14, 165-167. https://doi.org/10.3892/ijmm.14.2.165
MLA
Belloni, A. S., Macchi, C., Rebuffat, P., Conconi, M. T., Malendowicz, L. K., Parnigotto, P. P., Nussdorfer, G. G."Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro". International Journal of Molecular Medicine 14.2 (2004): 165-167.
Chicago
Belloni, A. S., Macchi, C., Rebuffat, P., Conconi, M. T., Malendowicz, L. K., Parnigotto, P. P., Nussdorfer, G. G."Effect of ghrelin on the apoptotic deletion rate of different types of cells cultured in vitro". International Journal of Molecular Medicine 14, no. 2 (2004): 165-167. https://doi.org/10.3892/ijmm.14.2.165
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