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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

CpG methylation of the ERα# and ERβ genes in breast cancer

  • Authors:
    • Sun Jung Kim
    • Tae Won Kim
    • Su-Young Lee
    • Sang-Jae Park
    • Hee Sung Kim
    • Ki-Wook Chung
    • Eun Sook Lee
    • Han-Sung Kang

  • View Affiliations / Copyright

    Affiliations: Department of Biology, Dongguk University, Seoul 100-715, Korea
  • Pages: 289-293
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.289
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Abstract

Aberrant methylation of promoter CpG islands is known to be responsible for the alteration and silencing of genes in cancer. The data presented here describes that the CpG methylations of ERα and ERβ are found in breast cancer tissues, and methylation exerts a considerable effect on gene silencing, investigated by bisulfite genomic sequencing and reverse transcriptase polymerase chain reaction. Consequently, hypermethylation of the ERα and ERβ genes was found in 66.0% and 50.0% of 50 breast cancers, respectively. Eleven of 50 samples (22.0%) did not show any methylation of either ERα or ERβ, whereas 19 samples (38.0%) showed methylation of both ERα and ERβ. The tumors that showed aberrant methylation of ERα and ERβ did not express mRNA, compared with unmethylated cases (p<0.01). The methylated case was negatively correlated with the expression of the ERα protein (p<0.01). In addition, ERβ methylation demonstrated significant associations with the lower level of Ki67 (9.36±2.43 versus 19.68±3.42, p=0.02). Although the number of samples was relatively small, our results suggest that DNA methylation in ERα and ERβ are present in breast cancer tissue, and that the methylation causes a significant effect on transcriptional silencing. Furthermore, the CpG methylation of the ERβ gene seems to play a role in cell proliferation of breast cancer tissue.

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Copy and paste a formatted citation
Spandidos Publications style
Kim SJ, Kim TW, Lee S, Park S, Kim HS, Chung K, Lee ES and Kang H: CpG methylation of the ERα# and ERβ genes in breast cancer. Int J Mol Med 14: 289-293, 2004.
APA
Kim, S.J., Kim, T.W., Lee, S., Park, S., Kim, H.S., Chung, K. ... Kang, H. (2004). CpG methylation of the ERα# and ERβ genes in breast cancer. International Journal of Molecular Medicine, 14, 289-293. https://doi.org/10.3892/ijmm.14.2.289
MLA
Kim, S. J., Kim, T. W., Lee, S., Park, S., Kim, H. S., Chung, K., Lee, E. S., Kang, H."CpG methylation of the ERα# and ERβ genes in breast cancer". International Journal of Molecular Medicine 14.2 (2004): 289-293.
Chicago
Kim, S. J., Kim, T. W., Lee, S., Park, S., Kim, H. S., Chung, K., Lee, E. S., Kang, H."CpG methylation of the ERα# and ERβ genes in breast cancer". International Journal of Molecular Medicine 14, no. 2 (2004): 289-293. https://doi.org/10.3892/ijmm.14.2.289
Copy and paste a formatted citation
x
Spandidos Publications style
Kim SJ, Kim TW, Lee S, Park S, Kim HS, Chung K, Lee ES and Kang H: CpG methylation of the ERα# and ERβ genes in breast cancer. Int J Mol Med 14: 289-293, 2004.
APA
Kim, S.J., Kim, T.W., Lee, S., Park, S., Kim, H.S., Chung, K. ... Kang, H. (2004). CpG methylation of the ERα# and ERβ genes in breast cancer. International Journal of Molecular Medicine, 14, 289-293. https://doi.org/10.3892/ijmm.14.2.289
MLA
Kim, S. J., Kim, T. W., Lee, S., Park, S., Kim, H. S., Chung, K., Lee, E. S., Kang, H."CpG methylation of the ERα# and ERβ genes in breast cancer". International Journal of Molecular Medicine 14.2 (2004): 289-293.
Chicago
Kim, S. J., Kim, T. W., Lee, S., Park, S., Kim, H. S., Chung, K., Lee, E. S., Kang, H."CpG methylation of the ERα# and ERβ genes in breast cancer". International Journal of Molecular Medicine 14, no. 2 (2004): 289-293. https://doi.org/10.3892/ijmm.14.2.289
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