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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2004 Volume 14 Issue 2

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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August 2004 Volume 14 Issue 2

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Article

Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats

  • Authors:
    • Adolfo Gavelli
    • Patrick Baqué
    • Nicole Brossettej
    • André Bourgeon
    • Pascal Staccini
    • Bernard Rossi
    • Valérie Pierrefite-Carle

  • View Affiliations / Copyright

    Affiliations: Unité INSERM 364, Faculté de Médecine, 06107 Nice cédex 2, France
  • Pages: 323-325
    |
    Published online on: August 1, 2004
       https://doi.org/10.3892/ijmm.14.2.323
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Abstract

The bacterial cytosine deaminase (CD) gene, associated to the 5-fluorocytosine (5-FC) prodrug, is one of the more widely used suicide systems in gene therapy. Introduction of the CD gene within a tumor induces, after 5-FC treatment of the animal, a local production of 5-fluorouracil (5-FU) resulting in intratumor chemotherapy. Destruction of the gene-modified tumor is then followed by the triggering of an anti-tumor immune reaction resulting in the regression of distant wild-type metastasis. In pre-clinical studies, 5-FC is generally administered by daily intraperitoneal injections. However, when used as an anti-fungal in humans, either IV or oral administration is used. In this study, we compared oral and intraperitoneal 5-FC administration in rats bearing a wild-type and a cytosine deaminase-expressing liver tumors. The results indicate that per os 5-FC administration is as efficient as intraperitoneal for the induction of CD-expressing tumor regression and the triggering of a distant bystander effect, acting on wild-type liver tumor and extra-hepatic metastasis.

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Copy and paste a formatted citation
Spandidos Publications style
Gavelli A, Baqué P, Brossettej N, Bourgeon A, Staccini P, Rossi B and Pierrefite-Carle V: Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats. Int J Mol Med 14: 323-325, 2004.
APA
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., & Pierrefite-Carle, V. (2004). Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats. International Journal of Molecular Medicine, 14, 323-325. https://doi.org/10.3892/ijmm.14.2.323
MLA
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., Pierrefite-Carle, V."Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats". International Journal of Molecular Medicine 14.2 (2004): 323-325.
Chicago
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., Pierrefite-Carle, V."Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats". International Journal of Molecular Medicine 14, no. 2 (2004): 323-325. https://doi.org/10.3892/ijmm.14.2.323
Copy and paste a formatted citation
x
Spandidos Publications style
Gavelli A, Baqué P, Brossettej N, Bourgeon A, Staccini P, Rossi B and Pierrefite-Carle V: Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats. Int J Mol Med 14: 323-325, 2004.
APA
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., & Pierrefite-Carle, V. (2004). Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats. International Journal of Molecular Medicine, 14, 323-325. https://doi.org/10.3892/ijmm.14.2.323
MLA
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., Pierrefite-Carle, V."Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats". International Journal of Molecular Medicine 14.2 (2004): 323-325.
Chicago
Gavelli, A., Baqué, P., Brossettej, N., Bourgeon, A., Staccini, P., Rossi, B., Pierrefite-Carle, V."Per os administration of 5-fluorocytosine is effective in the regression of CD-expressing liver metastases in rats". International Journal of Molecular Medicine 14, no. 2 (2004): 323-325. https://doi.org/10.3892/ijmm.14.2.323
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