Blood antioxidant parameters in patients with diabetic retinopathy

Siemianowicz,Krzysztof; Gminski,Jan; Telega,Alicja; Wójcik,Aneta; Posielezna,Barbara; Grabowska-Bochenek,Rozalia; Francuz,Tomasz

doi:10.3892/ijmm.14.3.433

September 2004 Volume 14 Issue 3

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September 2004 Volume 14 Issue 3

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Article

Blood antioxidant parameters in patients with diabetic retinopathy

Authors:
- Krzysztof Siemianowicz
- Jan Gminski
- Alicja Telega
- Aneta Wójcik
- Barbara Posielezna
- Rozalia Grabowska-Bochenek
- Tomasz Francuz
View Affiliations / Copyright

Affiliations: Department of Experimental and Clinical Biochemistry, Silesian Medical Academy, 40-752 Katowice, Poland. ksiem@mp.pl
Pages: 433-437
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Published online on: September 1, 2004

https://doi.org/10.3892/ijmm.14.3.433
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Abstract

It has been postulated that enhanced generation of reactive oxygen species (ROS) may take part in a pathogenesis of diabetic microvascular complication - retinopathy. There are two types of diabetic retinopathy, non-proliferative (simplex) and proliferative. ROS are anihilated by an intracelluar enzymatic system composed mainly of glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT). Beta-carotene, tocopherols and ascorbic acid are major components of serum antioxidants. All serum antioxidants are usually measured together as total antioxidant status (TAS). Erythrocyte activities of GPx, SOD, CAT and TAS were measured in diabetic patients without retinopathy, with non-proliferative and proliferative retinopathy. Obtained results were correlated with a period of diabetic history and a period of insulin treatment. SOD was significantly elevated in diabetics with non-proliferative retinopathy compared to patients without retinopathy. TAS was significantly lower in patients with proliferative retinopathy than in diabetics not developing retinopathy. Only CAT was significantly negatively correlated with the period of insulin treatment. This significant negative correlation was also observed in a subgroup of patients with proliferative retinopathy.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Blood antioxidant parameters in patients with diabetic retinopathy

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Abstract

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