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Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon.

  • Authors:
    • Nobuto Kitamura
    • Harukazu Tohyama
    • Jun Nishihira
    • Motoko Hatano
    • Masaki Suzuki
    • Kazunori Yasuda

  • View Affiliations

  • Published online on: October 1, 2004     https://doi.org/10.3892/ijmm.14.4.537
  • Pages: 537-580
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Abstract

Manganese superoxide dismutase (Mn-SOD) is a key antioxidant enzyme that prevents reactive oxygen species (ROS) damage to biological tissues. Although Mn-SOD has been investigated for a variety of cells, little is known about its expression in the tendon, particularly in the stress-deprived condition. The present study demonstrated that Mn-SOD is excessively expressed in the cultured fibroblasts derived from the stress-deprived patellar tendon in the rat using subtractive hybridization analysis. In addition, we confirmed that the expression of Mn-SOD is up-regulated in the stress-deprived patellar tendon in vivo at both the mRNA and protein levels. These results suggest that Mn-SOD may play a role in regulating ROS and matrix degradation involving mechanical deterioration of the stress-deprived tendon tissue.

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Journal Cover

October 2004
Volume 14 Issue 4

Print ISSN: 1107-3756
Online ISSN:1791-244X

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  • Journal Metrics
  • Impact Factor: 5.4
  • Ranked Medicine Research and Experimental
    (total number of cites)
  • CiteScore: 10.7
  • CiteScore Rank: Q1: #35/328 Biochemistry, Genetics and Molecular Biology
  • Source Normalized Impact per Paper (SNIP): 0.994
  • SCImago Journal Rank (SJR): 0.922
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Spandidos Publications style
Kitamura N, Tohyama H, Nishihira J, Hatano M, Suzuki M and Yasuda K: Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon.. Int J Mol Med 14: 537-580, 2004
APA
Kitamura, N., Tohyama, H., Nishihira, J., Hatano, M., Suzuki, M., & Yasuda, K. (2004). Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon.. International Journal of Molecular Medicine, 14, 537-580. https://doi.org/10.3892/ijmm.14.4.537
MLA
Kitamura, N., Tohyama, H., Nishihira, J., Hatano, M., Suzuki, M., Yasuda, K."Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon.". International Journal of Molecular Medicine 14.4 (2004): 537-580.
Chicago
Kitamura, N., Tohyama, H., Nishihira, J., Hatano, M., Suzuki, M., Yasuda, K."Stress deprivation enhances manganese superoxide dismutase expression in the rat patellar tendon.". International Journal of Molecular Medicine 14, no. 4 (2004): 537-580. https://doi.org/10.3892/ijmm.14.4.537