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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October 2004 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 4

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Article

Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.

  • Authors:
    • Atsuhiro Araki
    • Shoichi Hazama
    • Kiyoshi Yoshimura
    • Shigefumi Yoshino
    • Norio Iizuka
    • Masaaki Oka

  • View Affiliations / Copyright

    Affiliations: Department of Surgery II, Yamaguchi University School of Medicine, 1-1-1 Minami-Kogushi, Ube, Yamaguchi 755-8505, Japan.
  • Pages: 571-577
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.4.571
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Abstract

Although interleukin (IL)-15 augments innate and acquired immunities, IL-15 expression is controlled at the levels of transcription, translation and intracellular trafficking. We constructed plasmid vectors encoding the murine mature-IL-15 cDNA linked to an Igkappa leader sequence and full-length murine IL-15 cDNA to evaluate the efficacy of the mature-IL-15 vector. Weakly immunogenic colon 26 cells were transfected with the above-mentioned vectors or with empty vector (mock). Transfectants with mature-IL-15 produced significantly higher levels of IL-15 than did transfectants with full-length IL-15. When injected into syngeneic BALB/c mice, transfectants secreting high levels of IL-15 were rejected completely. Depletion of natural killer cells or CD4+ T cells did not affect the growth of transfectants. In contrast, transfectants treated with anti-CD8 antibody re-grew 1 month later after implantation. These findings indicate that CD8+ T cells are required for complete rejection of the tumor. Gene therapy with transfectants expressing mature-IL-15 containing the Igkappa leader sequence may be useful as a tumor vaccine.

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Copy and paste a formatted citation
Spandidos Publications style
Araki A, Hazama S, Yoshimura K, Yoshino S, Iizuka N and Oka M: Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.. Int J Mol Med 14: 571-577, 2004.
APA
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., & Oka, M. (2004). Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.. International Journal of Molecular Medicine, 14, 571-577. https://doi.org/10.3892/ijmm.14.4.571
MLA
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., Oka, M."Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.". International Journal of Molecular Medicine 14.4 (2004): 571-577.
Chicago
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., Oka, M."Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.". International Journal of Molecular Medicine 14, no. 4 (2004): 571-577. https://doi.org/10.3892/ijmm.14.4.571
Copy and paste a formatted citation
x
Spandidos Publications style
Araki A, Hazama S, Yoshimura K, Yoshino S, Iizuka N and Oka M: Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.. Int J Mol Med 14: 571-577, 2004.
APA
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., & Oka, M. (2004). Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.. International Journal of Molecular Medicine, 14, 571-577. https://doi.org/10.3892/ijmm.14.4.571
MLA
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., Oka, M."Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.". International Journal of Molecular Medicine 14.4 (2004): 571-577.
Chicago
Araki, A., Hazama, S., Yoshimura, K., Yoshino, S., Iizuka, N., Oka, M."Tumor secreting high levels of IL-15 induces specific immunity to low immunogenic colon adenocarcinoma via CD8+ T cells.". International Journal of Molecular Medicine 14, no. 4 (2004): 571-577. https://doi.org/10.3892/ijmm.14.4.571
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