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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October 2004 Volume 14 Issue 4

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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October 2004 Volume 14 Issue 4

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Article

Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.

  • Authors:
    • Ahmad Piroozmand
    • A Hajime Koyama
    • Yoshiko Shimada
    • Mikako Fujita
    • Tsutomu Arakawa
    • Akio Adachi

  • View Affiliations / Copyright

    Affiliations: Department of Virology, The University of Tokushima Graduate School of Medicine, Tokushima 770-8503, Japan.
  • Pages: 641-646
    |
    Published online on: October 1, 2004
       https://doi.org/10.3892/ijmm.14.4.641
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Abstract

The sensitivity of a Us3-deletion mutant virus of herpes simplex virus type 1 (HSV-1) to consensus interferon (IFN) was compared with that of parental wild-type (wt) and the repaired viruses. Although one-step growth of the Us3-deficient virus in the IFN-treated HEp-2 cells was not markedly affected at a high multiplicity of infection (MOI), both the progeny virus yield and cytopathic effect were suppressed in a significantly higher degree in the mutant virus-infected cells than those in wt or the repaired virus-infected cells. This enhanced IFN-sensitivity of the mutant virus was more clearly demonstrated by the infection at a low MOI. In addition, both the size and number of plaques of the Us3-deficient virus in Vero cells were remarkably reduced with increasing concentrations of IFN, compared to those of wt or the repaired virus. These results indicate that the deletion of Us3 gene makes HSV-1 more sensitive to IFN.

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Copy and paste a formatted citation
Spandidos Publications style
Piroozmand A, Koyama A, Shimada Y, Fujita M, Arakawa T and Adachi A: Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.. Int J Mol Med 14: 641-646, 2004.
APA
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., & Adachi, A. (2004). Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.. International Journal of Molecular Medicine, 14, 641-646. https://doi.org/10.3892/ijmm.14.4.641
MLA
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., Adachi, A."Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.". International Journal of Molecular Medicine 14.4 (2004): 641-646.
Chicago
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., Adachi, A."Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.". International Journal of Molecular Medicine 14, no. 4 (2004): 641-646. https://doi.org/10.3892/ijmm.14.4.641
Copy and paste a formatted citation
x
Spandidos Publications style
Piroozmand A, Koyama A, Shimada Y, Fujita M, Arakawa T and Adachi A: Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.. Int J Mol Med 14: 641-646, 2004.
APA
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., & Adachi, A. (2004). Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.. International Journal of Molecular Medicine, 14, 641-646. https://doi.org/10.3892/ijmm.14.4.641
MLA
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., Adachi, A."Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.". International Journal of Molecular Medicine 14.4 (2004): 641-646.
Chicago
Piroozmand, A., Koyama, A., Shimada, Y., Fujita, M., Arakawa, T., Adachi, A."Role of Us3 gene of herpes simplex virus type 1 for resistance to interferon.". International Journal of Molecular Medicine 14, no. 4 (2004): 641-646. https://doi.org/10.3892/ijmm.14.4.641
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