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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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December 2004 Volume 14 Issue 6

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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December 2004 Volume 14 Issue 6

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Article

Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells

  • Authors:
    • Sergio De Angeli
    • Laura Del Pup
    • Erica Febas
    • Maria Teresa Conconi
    • Mara Tommasini
    • Rosa Di Liddo
    • Giovanna Albertin
    • Pier Paolo Parnigotto
    • Gastone G. Nussdorfer

  • View Affiliations / Copyright

    Affiliations: Cell Culture Laboratory, Transfusional Center, Treviso Regional Hospital, I-31100 Treviso, Italy
  • Pages: 1083-1086
    |
    Published online on: December 1, 2004
       https://doi.org/10.3892/ijmm.14.6.1083
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Abstract

The improvement of techniques for in vitro expansion of cord blood (CB) hematopoietic stem cells (SCs) is, at present, one main task of tissue engineering. Hence, we investigated whether endothelin-1 (ET-1) and adrenomedullin (AM), two regulatory peptides exerting growth promoting action on several cell systems, favor the in vitro expansion of CB SCs in liquid culture. CB hematopoietic cell middle-term expansion was carried out in a stroma-free liquid culture medium in the presence of ET-1, AM and three different cytokine combinations. After two weeks of incubation, aliquots of expanded-cell suspension were seeded on semisolid medium and clonogenic tests were carried out by counting the number of colony forming units (CFUs) after 14 days of culture. Neither ET-1 nor AM (2.5x10−8 M) were per se able to significantly increase the CFU number, but both peptides magnified the pro-expansive effects of some cytokine cocktails. In light of these findings, we conclude that ET-1 and AM are to be considered novel promising molecules that, in association with cytokines, can be utilized as pro-expansive factors of CB SCs in prevision of their clinical use in allogeneic transplantation.

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Copy and paste a formatted citation
Spandidos Publications style
De Angeli S, Del Pup L, Febas E, Conconi MT, Tommasini M, Di Liddo R, Albertin G, Parnigotto PP and Nussdorfer GG: Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells. Int J Mol Med 14: 1083-1086, 2004.
APA
De Angeli, S., Del Pup, L., Febas, E., Conconi, M.T., Tommasini, M., Di Liddo, R. ... Nussdorfer, G.G. (2004). Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells. International Journal of Molecular Medicine, 14, 1083-1086. https://doi.org/10.3892/ijmm.14.6.1083
MLA
De Angeli, S., Del Pup, L., Febas, E., Conconi, M. T., Tommasini, M., Di Liddo, R., Albertin, G., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells". International Journal of Molecular Medicine 14.6 (2004): 1083-1086.
Chicago
De Angeli, S., Del Pup, L., Febas, E., Conconi, M. T., Tommasini, M., Di Liddo, R., Albertin, G., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells". International Journal of Molecular Medicine 14, no. 6 (2004): 1083-1086. https://doi.org/10.3892/ijmm.14.6.1083
Copy and paste a formatted citation
x
Spandidos Publications style
De Angeli S, Del Pup L, Febas E, Conconi MT, Tommasini M, Di Liddo R, Albertin G, Parnigotto PP and Nussdorfer GG: Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells. Int J Mol Med 14: 1083-1086, 2004.
APA
De Angeli, S., Del Pup, L., Febas, E., Conconi, M.T., Tommasini, M., Di Liddo, R. ... Nussdorfer, G.G. (2004). Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells. International Journal of Molecular Medicine, 14, 1083-1086. https://doi.org/10.3892/ijmm.14.6.1083
MLA
De Angeli, S., Del Pup, L., Febas, E., Conconi, M. T., Tommasini, M., Di Liddo, R., Albertin, G., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells". International Journal of Molecular Medicine 14.6 (2004): 1083-1086.
Chicago
De Angeli, S., Del Pup, L., Febas, E., Conconi, M. T., Tommasini, M., Di Liddo, R., Albertin, G., Parnigotto, P. P., Nussdorfer, G. G."Adrenomedullin and endothelin-1 stimulate in vitro expansion of cord blood hematopoietic stem cells". International Journal of Molecular Medicine 14, no. 6 (2004): 1083-1086. https://doi.org/10.3892/ijmm.14.6.1083
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