Expression of thrombospondin-1 in prostate-derived cell lines

  • Authors:
    • Manuela Bastian
    • Michael Steiner
    • Peter Schuff-Werner
  • View Affiliations

  • Published online on: January 1, 2005     https://doi.org/10.3892/ijmm.15.1.49
  • Pages: 49-56
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Abstract

Thrombospondin-1 (TSP-1) is a multifunctional matricellular glycoprotein involved in several mechanisms critical to the formation and progression of solid tumors including cell adhesion, proliferation, migration, invasion, and angiogenesis. However, work related to TSP-1 expression and functionality in prostate cancer is limited. Expression experiments in the present study demonstrated lower expression of TSP-1 in the prostate cancer cell lines DU 145 and LNCaP compared to SV40-immortalized prostatic epithelial cells PNT 1A. All three cell lines expressed the TSP-1 receptor CD36. Exogenously added TSP-1 modulated the cellular phenotype of LNCaP cells, which demonstrated decreased proliferation rate and partly entered apoptosis. Collectively, these data support the concept that partial or complete loss of TSP-1 synthesis may provide tumor cells with a proliferation advantage. In addition, TSP-1 located at the border between tumor and stroma as observed in primary prostate tumors may act as a barrier of tumor growth depending on the TSP-1 receptor repertoire of the tumor cells.

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January 2005
Volume 15 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Bastian M, Steiner M and Schuff-Werner P: Expression of thrombospondin-1 in prostate-derived cell lines. Int J Mol Med 15: 49-56, 2005
APA
Bastian, M., Steiner, M., & Schuff-Werner, P. (2005). Expression of thrombospondin-1 in prostate-derived cell lines. International Journal of Molecular Medicine, 15, 49-56. https://doi.org/10.3892/ijmm.15.1.49
MLA
Bastian, M., Steiner, M., Schuff-Werner, P."Expression of thrombospondin-1 in prostate-derived cell lines". International Journal of Molecular Medicine 15.1 (2005): 49-56.
Chicago
Bastian, M., Steiner, M., Schuff-Werner, P."Expression of thrombospondin-1 in prostate-derived cell lines". International Journal of Molecular Medicine 15, no. 1 (2005): 49-56. https://doi.org/10.3892/ijmm.15.1.49