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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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February 2005 Volume 15 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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February 2005 Volume 15 Issue 2

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Article

Molecular cloning and expression of a novel alternative splice variant of BRDT gene

  • Authors:
    • Ying Zheng
    • Wa Yuan
    • Zuomin Zhou
    • Min Xu
    • Jia-Hao Sha

  • View Affiliations / Copyright

    Affiliations: Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, P.R. China
  • Pages: 315-321
    |
    Published online on: February 1, 2005
       https://doi.org/10.3892/ijmm.15.2.315
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Abstract

In this study, a human adult testis cDNA microarray was constructed and hybridized with 33P-labeled human adult testis, embryo testis and sperm cDNA probes, respectively. A novel alternative splice variant of BRDT gene, named BRDT-NY, presumably involved in testicular function was cloned. It was expressed 3.96-fold more in human adult than embryo testis and also expressed in human spermatozoa. Similarly, RT-PCR revealed a differential expression pattern of this gene in human adult testes and fetal testes. The full length of BRDT-NY was 3438 bp and contained a 2883 bp open reading frame, encoding a 960-amino-acid protein. Sequence analysis showed that it has two bromodomains in N-terminal of the protein. Multiple tissue RT-PCR results showed that BRDT-NY was exclusively expressed in testis. mRNA expression of BRDT-NY gene was deleted in some azoospermic patients' testes. These experiments suggested that BRDT-NY gene may have an important role in the process of spermatogenesis and may be correlated with male infertility.

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Copy and paste a formatted citation
Spandidos Publications style
Zheng Y, Yuan W, Zhou Z, Xu M and Sha J: Molecular cloning and expression of a novel alternative splice variant of BRDT gene. Int J Mol Med 15: 315-321, 2005.
APA
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., & Sha, J. (2005). Molecular cloning and expression of a novel alternative splice variant of BRDT gene. International Journal of Molecular Medicine, 15, 315-321. https://doi.org/10.3892/ijmm.15.2.315
MLA
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., Sha, J."Molecular cloning and expression of a novel alternative splice variant of BRDT gene". International Journal of Molecular Medicine 15.2 (2005): 315-321.
Chicago
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., Sha, J."Molecular cloning and expression of a novel alternative splice variant of BRDT gene". International Journal of Molecular Medicine 15, no. 2 (2005): 315-321. https://doi.org/10.3892/ijmm.15.2.315
Copy and paste a formatted citation
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Spandidos Publications style
Zheng Y, Yuan W, Zhou Z, Xu M and Sha J: Molecular cloning and expression of a novel alternative splice variant of BRDT gene. Int J Mol Med 15: 315-321, 2005.
APA
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., & Sha, J. (2005). Molecular cloning and expression of a novel alternative splice variant of BRDT gene. International Journal of Molecular Medicine, 15, 315-321. https://doi.org/10.3892/ijmm.15.2.315
MLA
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., Sha, J."Molecular cloning and expression of a novel alternative splice variant of BRDT gene". International Journal of Molecular Medicine 15.2 (2005): 315-321.
Chicago
Zheng, Y., Yuan, W., Zhou, Z., Xu, M., Sha, J."Molecular cloning and expression of a novel alternative splice variant of BRDT gene". International Journal of Molecular Medicine 15, no. 2 (2005): 315-321. https://doi.org/10.3892/ijmm.15.2.315
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