Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?

  • Authors:
    • András Mihály
    • Sándor Borbély
    • Ildikó Világi
    • László Détári
    • Roland Weiczner
    • Zsolt Zádor
    • Beáta Krisztin-Péva
    • Andrea Bagosi
    • Zsolt Kopniczky
    • Erno Zádor
  • View Affiliations

  • Published online on: March 1, 2005     https://doi.org/10.3892/ijmm.15.3.481
  • Pages: 481-486
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Abstract

The effect of acute brief seizures on neocortical c-fos expression was investigated in rats injected with 5 mg/kg 4-aminopyridine. Electroencephalography in freely moving animals with implanted neocortical electrodes detected an average of 2.67 tonic-clonic convulsions within 1 h following the 4-AP treatment. Tissue samples of the somatosensory neocortex were collected at 30 min, 1 h, 3 h, 5 h and 8 h following the treatment for PCR and immunohistochemistry. The c-fos mRNA displayed the first significant rise at 1 h, and remained significantly higher through 3 h. The number of c-fos protein immunoreactive cells was significantly elevated already at 30 min, peaked at 1 h, and declined by 5 h. We conclude that in repetitive, brief seizures, the first convulsion does not increase c-fos RNA transcription, whilst the second causes a long-lasting gene expression and a large increase of c-fos protein synthesis. The phenomenon may have implications in the pathogenesis of human and animal epilepsies.

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March 2005
Volume 15 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Mihály A, Borbély S, Világi I, Détári L, Weiczner R, Zádor Z, Krisztin-Péva B, Bagosi A, Kopniczky Z, Zádor E, Zádor E, et al: Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?. Int J Mol Med 15: 481-486, 2005.
APA
Mihály, A., Borbély, S., Világi, I., Détári, L., Weiczner, R., Zádor, Z. ... Zádor, E. (2005). Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?. International Journal of Molecular Medicine, 15, 481-486. https://doi.org/10.3892/ijmm.15.3.481
MLA
Mihály, A., Borbély, S., Világi, I., Détári, L., Weiczner, R., Zádor, Z., Krisztin-Péva, B., Bagosi, A., Kopniczky, Z., Zádor, E."Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?". International Journal of Molecular Medicine 15.3 (2005): 481-486.
Chicago
Mihály, A., Borbély, S., Világi, I., Détári, L., Weiczner, R., Zádor, Z., Krisztin-Péva, B., Bagosi, A., Kopniczky, Z., Zádor, E."Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?". International Journal of Molecular Medicine 15, no. 3 (2005): 481-486. https://doi.org/10.3892/ijmm.15.3.481