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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
March 2005 Volume 15 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Role of regucalcin in maintaining cell homeostasis and function (Review)

Masayoshi Yamaguchi
Pages: 371-389
Published online on: 01 March 2005

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Prevention of tissue injury by ribbon antisense to TGF-β1 in the kidney

Young-Kook Choi, Ik-Jae Moon, Hyun-Kyung Jung, Byung-Chul Jang, Seong-Il Seo, Jong-Gu Park
Pages: 391-399
Published online on: 01 March 2005

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Protective effects of a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia and Agaricus blazei murill against X-irradiation in B6C3F1 mice: Increased small intestinal crypt survival and prolongation of average time to animal death

Nanami Kubo, Yuki Myojin, Fumio Shimamoto, Naoki Kashimoto, Eikai Kyo, Kenji Kamiya, Hiromitsu Watanabe
Pages: 401-406
Published online on: 01 March 2005

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Article

Dislocation of tight junction proteins without F-actin disruption in inactive Crohn's disease

Nobuhide Oshitani, Kenji Watanabe, Shiro Nakamura, Yasuhiro Fujiwara, Kazuhide Higuchi, Tetsuo Arakawa
Pages: 407-410
Published online on: 01 March 2005

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Cerebellin in the rat adrenal gland: gene expression and effects of CER and [des-Ser1]CER on the secretion and growth of cultured adrenocortical cells

Marcin Rucinski, Giovanna Albertin, Raffaella Spinazzi, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Ludwick K. Malendowicz
Pages: 411-415
Published online on: 01 March 2005

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Significance of increased proliferation of immature plasma cells in the appendix of patients with ulcerative colitis

Tomohiro Kawachiya, Nobuhide Oshitani, Yoshio Jinno, Kenji Watanabe, Shiro Nakamura, Yasuhiro Fujiwara, Kazuhide Higuchi, Kiyoshi Maeda, Yukio Nishiguchi, Kosei Hirakawa, Takayuki Matsumoto, Tetsuo Arakawa
Pages: 417-423
Published online on: 01 March 2005

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Histologic and genetic analysis of the gallbladder in patients with occult pancreatobiliary reflux

Takao Itoi, Akihiko Tsuchida, Fumihide Itokawa, Atsushi Sofuni, Toshio Kurihara, Takayoshi Tsuchiya, Fuminori Moriyasu, Kazuhiko Kasuya, Hiromi Serizawa
Pages: 425-430
Published online on: 01 March 2005

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Cholestasis in a rat model of graft-versus-host disease is accompanied by alteration of the expression and distribution of tight-junction-associated proteins

Kurumi Sasatomi, Shotaro Sakisaka, Takumi Kawaguchi, Shinichiro Hanada, Eitaro Taniguchi, Hironori Koga, Masaru Harada, Michio Sata
Pages: 431-436
Published online on: 01 March 2005

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Comet-assay in combination with PNA-FISH detects mutagen-induced DNA damage and specific repeat sequences in the damaged DNA of transformed cells

G. Hovhannisyan, A. Rapp, R. Arutyunyan, K. O. Greulich, E. Gebhart
Pages: 437-442
Published online on: 01 March 2005

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Polymorphisms for microsomal epoxide hydrolase and genetic susceptibility to COPD

Jong Y. Park, Lan Chen, Nina Wadhwa, Melvyn S. Tockman
Pages: 443-448
Published online on: 01 March 2005

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Metformin-induced suppression of glucose-6-phosphatase expression is independent of insulin signaling in rat hepatoma cells

Kohei Morioka, Kaname Nakatani, Kazutaka Matsumoto, Hideki Urakawa, Nagako Kitagawa, Akira Katsuki, Yasuko Hori, Esteban C. Gabazza, Yutaka Yano, Junji Nishioka, Tsutomu Nobori, Yasuhiro Sumida, Yukihiko Adachi
Pages: 449-452
Published online on: 01 March 2005

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Analysis of abnormally expressed genes in synovium from patients with rheumatoid arthritis using a column gel electrophoresis-coupled subtractive hybridization technique

Takashi Tomoo, Akito Tsutsumi, Takanori Yasukochi, Kotaro Ikeda, Naoyuki Ochiai, Kazuo Ozawa, Yasuhiko Shibanaka, Satoshi Ito, Isao Matsumoto, Daisuke Goto, Takayuki Sumida
Pages: 453-457
Published online on: 01 March 2005

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Article

Endothelium dysfunction markers in patients with diabetic retinopathy

Krzysztof Siemianowicz, Tomasz Francuz, Jan Gminski, Alicja Telega, Marcin Syzdól
Pages: 459-462
Published online on: 01 March 2005

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Shoyu polysaccharides from soy sauce improve quality of life for patients with seasonal allergic rhinitis: A double-blind placebo-controlled clinical study

Makio Kobayashi, Hiroaki Matsushita, Ryo-Ichi Tsukiyama, Masami Saito, Toshiro Sugita
Pages: 463-467
Published online on: 01 March 2005

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Endothelin-1 and adrenomedullin enhance the growth of human adrenocortical carcinoma-derived SW-13 cell line by stimulating proliferation and inhibiting apoptosis

Giovanna Albertin, Gianni Carraro, Lucia Petrelli, Diego Guidolin, Giuliano Neri, Gastone G. Nussdorfer
Pages: 469-474
Published online on: 01 March 2005

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Article

Modulation of cell death sensitivity by mutant p53 in HCV core-expressing cells

Jae-We Cho, Kun Park, Gi Ryang Kweon, Jong-Chun Park, Je-Chul Lee, Won-Ki Baek, Byeong-Churl Jang, Seong-Il Suh, Min-Ho Suh
Pages: 475-480
Published online on: 01 March 2005

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Article

Neocortical c-fos mRNA transcription in repeated, brief, acute seizures: Is c-fos a coincidence detector?

András Mihály, Sándor Borbély, Ildikó Világi, László Détári, Roland Weiczner, Zsolt Zádor, Beáta Krisztin-Péva, Andrea Bagosi, Zsolt Kopniczky, Erno Zádor
Pages: 481-486
Published online on: 01 March 2005

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Article

Mutation analysis of HNF-4 binding sites in the human glucose-6-phosphatase promoter

Keiko Hirota, Hisanori Aoyama, Akiyoshi Fukamizu
Pages: 487-490
Published online on: 01 March 2005

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Immune modulatory effects of Prunella vulgaris L.

Xuya Fang, Raymond Chuen-Chung Chang, Wai-Hung Yuen, Sze Yong Zee
Pages: 491-496
Published online on: 01 March 2005

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Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile

Margaret E. Tome, Margaret M. Briehl, Norbert W. Lutz
Pages: 497-501
Published online on: 01 March 2005

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Diminished PKC activity and decreased binding of transcription factors are involved in the impaired production of nitric oxide by macrophages from tumor-bearing mice

Michael R. Di Napoli, Marta Torroella-Kouri, Giselle Perry, Diana M. Lopez
Pages: 503-511
Published online on: 01 March 2005

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Article

Characterization of OEBT, a LIM protein

Andreas Teufel, Arndt Weinmann, Peter R. Galle, Ansgar W. Lohse
Pages: 513-518
Published online on: 01 March 2005

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Article

Fish soluble Toll-like receptor 5 (TLR5S) is an acute-phase protein with integral flagellin-recognition activity

Hironobu Tsukada, Aya Fukui, Tadayuki Tsujita, Misako Matsumoto, Takaji Iida, Tsukasa Seya
Pages: 519-525
Published online on: 01 March 2005

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Identification and characterization of rat Wnt6 and Wnt10a genes in silico

Yuriko Katoh, Masaru Katoh
Pages: 527-531
Published online on: 01 March 2005

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Identification and characterization of rat Ror1 and Ror2 genes in silico

Masuko Katoh, Masaru Katoh
Pages: 533-538
Published online on: 01 March 2005

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Article

Gleditsia sinensis fruit extract-induced apoptosis involves changes of reactive oxygen species level, mitochondrial membrane depolarization and caspase 3 activation

Chung Hin Chui, Fung Yi Lau, Albert Sun Chi Chan, Gregory Yin Ming Cheng, Raymond Siu Ming Wong, Ka Bik Lai, Stanton Hon Lung Kok, Terry Tin Lok Au Yeung, Ivy Tuang Ngo Teo, Mable Yin Chun Yau, Filly Cheung, Chor Hing Cheng, Johnny Cheuk On Tang
Pages: 539-543
Published online on: 01 March 2005

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Identification and characterization of human ZNF18 gene in silico

Kenichi Yoshida
Pages: 545-548
Published online on: 01 March 2005

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Review Open Access

Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Review Open Access

Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Review Open Access

Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Published online on: 01 July 2026

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Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

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Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

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ABCG2 transporter: Structural and functional associations with gout (Review)

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Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

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Published online on: 30 June 2026

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[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

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Published online on: 26 June 2026

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