Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

Watanabe,Makoto; Goto,Naohisa; Watanabe,Yuko; Nishiguchi,Seiji; Shimada,Kazunori; Yasunga,Teruo; Yamanishi,Hiromichi

doi:10.3892/ijmm.15.4.561

April 2005 Volume 15 Issue 4

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April 2005 Volume 15 Issue 4

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Article

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

Authors:
- Makoto Watanabe
- Naohisa Goto
- Yuko Watanabe
- Seiji Nishiguchi
- Kazunori Shimada
- Teruo Yasunga
- Hiromichi Yamanishi
View Affiliations / Copyright

Affiliations: Hirakata Ryoikuen, Hirakata, Osaka 573-0122, Japan
Pages: 561-566
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Published online on: April 1, 2005

https://doi.org/10.3892/ijmm.15.4.561
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Abstract

Interleukin-18 (IL-18) is one of the pivotal cytokines controlling the defense mechanism called inflammation. As a first step to develop proteins for controlling the IL-18 level, we initiated a study of IL-18-binding proteins (IL-18BPs). Twenty-four IL-18BP family members, 11 from vertebrates and 13 from chordopoxviruses, were picked from the NCBI database. Eight of these vertebrate IL-18BPs and two of the chordopoxvirus IL18-BPs were identified here and characterized as new members of the IL-18BP family. Their IL-18 binding domains were aligned and the distribution of highly conserved critical amino acid residues was analyzed and used to construct a phylogenetic tree. From this tree it was inferred that at least two independent events created two different ancestral viral IL-18BP genes by retroposition of IL-18BP genes from the vertebrate lineage. These two events are estimated to have occurred after an ancient mammalian IL-18BP gene diverged from birds, and before the mammalian IL-18BP gene diverged into human, ungulate and rodent IL-18BP genes. Moreover, our results suggest that IL-18BP and interleukin-1 receptor, type II (IL-1R2) had a common ancestral gene and diverged from the ancestral gene into IL-18BP and IL-1R2 genes in the fish period.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

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