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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2005 Volume 15 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Relevance of nuclear localization and functions of RNA helicase A

Hidetoshi Fujita, Takayuki Ohshima, Takayuki Oishi, Satoko Aratani, Ryouji Fujii, Akiyoshi Fukamizu, Toshihiro Nakajima
Pages: 555-560
Published online on: 01 April 2005

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Article

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

Makoto Watanabe, Naohisa Goto, Yuko Watanabe, Seiji Nishiguchi, Kazunori Shimada, Teruo Yasunga, Hiromichi Yamanishi
Pages: 561-566
Published online on: 01 April 2005

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Article

Adrenomedullin, ANP and BNP are colocalized in a subset of endocrine cells in the rat heart

Anna S. Belloni, Diego Guidolin, Roberta Salmaso, Sergio Bova, Gian Paolo Rossi, Gastone G. Nussdorfer
Pages: 567-571
Published online on: 01 April 2005

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Article

Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin, and neutrophil - platelet interaction in human coronary unstable plaques

Takeshi Ikuta, Takahiko Naruko, Yoshihiro Ikura, Masahiko Ohsawa, Hiroko Fukushima, Nobuyuki Shirai, Akira Itoh, Kazuo Haze, Shoichi Ehara, Yasuyuki Sasaki, Toshihiko Shibata, Shigefumi Suehiro, Makiko Ueda
Pages: 573-577
Published online on: 01 April 2005

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Article

Human adrenomedullin gene silencing by short interfering RNAs: A preliminary study

Giovanna Albertin, Gianni Carraro, Gastone G. Nussdorfer
Pages: 579-583
Published online on: 01 April 2005

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Article

Down-regulation of DMBT1 gene expression in human oral squamous cell carcinoma

Massao Alberto Imai, Tetsuhiro Moriya, Fabiana Lica Imai, Masashi Shiiba, Hiroki Bukawa, Hidetaka Yokoe, Katsuhiro Uzawa, Hideki Tanzawa
Pages: 585-589
Published online on: 01 April 2005

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Article

Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia

Haneen Sadick, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel
Pages: 591-596
Published online on: 01 April 2005

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Article

Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma

Hisako Uesugi, Katsuhiro Uzawa, Kenshi Kawasaki, Ken Shimada, Tetsuhiro Moriya, Akio Tada, Masashi Shiiba, Hideki Tanzawa
Pages: 597-602
Published online on: 01 April 2005

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Article

Protein and mRNA expression levels of VEGF-A and TGF-β1 in different types of human coronary atherosclerotic lesions

Dimitrios Panutsopulos, Efstathios Papalambros, Fragiska Sigala, Alexandros Zafiropoulos, Dimitrios L. Arvanitis, Demetrios A. Spandidos
Pages: 603-610
Published online on: 01 April 2005

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Article

Expression of the gene for hematopoietic cell specific protein is not restricted to cells of hematopoietic origin

Ulrike Fischer, Armin Michel, Eckart U. Meese
Pages: 611-615
Published online on: 01 April 2005

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Article

Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro

Limo Chen, Qiang Liu, Renyi Qin, Huangying Le, Ruijuan Xia, Weihua Li, Manoj Kumar
Pages: 617-626
Published online on: 01 April 2005

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Article

Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population

Gui Zhang, Qing-Ying Zhang, Xiao-Ping Miao, Dong-Xin Lin, You-Yong Lu
Pages: 627-632
Published online on: 01 April 2005

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Article

Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes

Qun Wang, Alicia Turlington, Stephan Heo, Andrea Blanco, Jian Tian, Zijia Xie, Bingfang Yan, Yinsheng Wan
Pages: 633-640
Published online on: 01 April 2005

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Article

Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil

Tobias Engl, Borna Relja, Iyad Natsheh, Jasmina Makarevic, Iris Müller, Wolf-Dietrich Beecken, Dietger Jonas, Roman A. Blaheta
Pages: 641-647
Published online on: 01 April 2005

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Article

Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli

Miki Murata, Yasushi Miura, Akira Hashiramoto, Hitomi Kitamura, Hiroki Kawasaki, Kazuko Shiozawa, Shinichi Yoshiya, Hisamitsu Baba, Kazuo Chihara, Shunichi Shiozawa
Pages: 649-653
Published online on: 01 April 2005

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Article

Clinical significance of abnormal lipoprotein patterns in liver diseases

Kinue Ooi, Katsuya Shiraki, Yuko Sakurai, Yoshitska Morishita, Tsutomu Nobori
Pages: 655-660
Published online on: 01 April 2005

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Article

Analysis of the apolipoprotein(a) size polymorphism in patients with systemic lupus erythematosus

Emmanouil Peros, Diego Geroldi, Serena Bugatti, Roberto Caporali, Paola Rossi, Carlomaurizio Montecucco, Angela D'Angelo, Enzo Emanuele
Pages: 661-665
Published online on: 01 April 2005

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Article

Involvement of NF-κB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma

Takahiro Taniguchi, Masato Takahashi, Fumiaki Shinohara, Tomonori Sato, Seishi Echigo, Hidemi Rikiishi
Pages: 667-673
Published online on: 01 April 2005

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Article

β-Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1 cells

Satoshi Uchiyama, Masayoshi Yamaguchi
Pages: 675-681
Published online on: 01 April 2005

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Article

Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity

Kumi Nagao, Junko H. Ohyashiki, Kazuma Ohyashiki, Keiko Tabata, Kenji Takai, Kazuhisa Kameyama, Soichi Kitano, Katsumi Kawano, Nozomu Hibi, Taichi Kanamaru, Hisashi Hisatomi
Pages: 683-688
Published online on: 01 April 2005

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Article

Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat

Masafumi Tomita, Hironobu Katsuyama, Toshiko Okuyama, Kazuo Hidaka, Yohsuke Minatogawa
Pages: 689-693
Published online on: 01 April 2005

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Article

Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells

Kiminori Matsubara, Changhu Xue, Xue Zhao, Masaharu Mori, Tatsuya Sugawara, Takashi Hirata
Pages: 695-699
Published online on: 01 April 2005

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Review

Vitamin D in normal and pathological parathyroid glands: New prospects for treating hyperparathyroidism (Review)

Pamela Correa Buchwald, Gunnar Westin, Göran Åkerström
Pages: 701-706
Published online on: 01 April 2005

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Article

Ghrelin, peptide YY and their receptors: Gene expression in brain from subjects with and without Prader-Willi syndrome

Zohreh Talebizadeh, Nataliya Kibiryeva, Douglas C. Bittel, Merlin G. Butler
Pages: 707-711
Published online on: 01 April 2005

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Article

Identification of active siRNAs against IGF-IR of porcine coronary smooth muscle cells in a heterologous cell line

Laura Poliseno, Monica Evangelista, Fernanda Ricci, Alessandra Bonotti, Monica Nannipieri, Giuseppe Rainaldi
Pages: 713-718
Published online on: 01 April 2005

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Article

Identification and characterization of a novel human nephronectin gene in silico

Jeffrey T.-J. Huang, Vivian Lee
Pages: 719-724
Published online on: 01 April 2005

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Article

Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation

Ming-Derg Lai, Wan-Chi Lin, Yih-Min Sun, Fu-Lin Chang
Pages: 725-734
Published online on: 01 April 2005

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Article

Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs

Kristin R. Landis-Piwowar, Deborah J. Kuhn, Sheng Biao Wan, Di Chen, Tak Hang Chan, Q. Ping Dou
Pages: 735-742
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt3 - Wnt9b gene cluster

Masaru Katoh
Pages: 743-747
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt5a and Wnt5b genes

Masuko Katoh, Masaru Katoh
Pages: 749-753
Published online on: 01 April 2005

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of adipocytes and their derived extracellular vesicles in the progression, diagnosis and treatment of liver diseases (Review)

Kangrong Li, Muhammad Zubair, Yongmin Yan, Jiahao Xu
Article Number: 293
Published online on: 20 August 2026

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Correction Open Access

[Corrigendum] EBM84 attenuates airway inflammation and mucus hypersecretion in an ovalbumin‑induced murine model of asthma

In Sik Shin, Mee Young Lee, Woo Young Jeon, Na Ra Shin, Chang Seob Seo, Hyekyung Ha
Article Number: 292
Published online on: 20 August 2026

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Review Open Access

Decoding fibroblast activation: Transcriptional networks in hepatic stellate cells and across fibrotic organs (Review)

Denita Charoenthanakitkul, Chaiyaboot Ariyachet
Article Number: 291
Published online on: 20 August 2026

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Review Open Access

Inflammatory bowel disease treatment: Mechanisms to clinical translation (Review)

Siqi Tang, Guoyou Gou, Youjia Liu, Fang Wang, Feihong Shu, Ya Deng, Ting Zhang, Jingyu Xu, Rui Xie
Article Number: 290
Published online on: 18 August 2026

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Review Open Access

Redox biology in PCOS: Biomarkers, mechanistic networks, and targeted interventions (Review)

Yuena Qiu, Xiaojing Guo, Jie An
Article Number: 289
Published online on: 18 August 2026

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Review Open Access

Glucose metabolism in osteoporosis: A potential therapeutic target (Review)

Shengyao Peng, Zhuo Yao, Junzhe Guo, Chi Zhang, Keda Yang, Lin Tao
Article Number: 288
Published online on: 17 August 2026

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Retraction Open Access

[Retracted] Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Article Number: 287
Published online on: 17 August 2026

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Article Open Access

α‑Cyperone targets the PAK1‑JNK/NF‑κB axis to modulate dendritic cells maturation and Th2/Th9 differentiation in an asthma model

Hang Hu, Xing Wang, Linlin Guo, Ziling Zeng, Hongmei Tang, Yun Zhang, Jiayao Duan, Kaijin Wang
Article Number: 286
Published online on: 14 August 2026

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Article Open Access

Early high‑frequency spinal cord stimulation modulates the ROS/p38 MAPK/NF‑κB and CXCL10/CXCR3 pathways to alleviate neuropathic pain and promote spinal cord injury repair

Sitong Su, Tao Liu, Honghui Lei, Yang Yu, Caizhi Ma, Xinglang Wang, Haoyuan Chen, Zebin Huang, Meiling Cheng, Tongtong Qian, Fangyong Wang
Article Number: 285
Published online on: 13 August 2026

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Shared mechanisms of musculoskeletal dysfunction in type 2 diabetes mellitus: Insights into future therapeutic directions (Review)

Zhenhong He, Hanyu Li, Yuhan Luo, Yingying Yu, Siyu Li, Tao Zhang, Dingsu Bao
Article Number: 284
Published online on: 12 August 2026

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Expression of Concern Open Access

[Expression of Concern] Exogenous spermine attenuates diabetic kidney injury in rats by inhibiting AMPK/mTOR signaling pathway

Xinying Zhang, Li Zhang, Zhe Chen, Siwei Li, Bingbing Che, Ningning Wang, Junting Chen, Changqing Xu, Can Wei
Article Number: 283
Published online on: 12 August 2026

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Article Open Access

G protein‑coupled receptor kinase 4 governs early kidney development via STAT3 and Nhe3a

Linh Anna Trúc Vu, Julian Gerhards, Lars D. Maerz, Martin D. Burkhalter, Melanie Philipp
Article Number: 282
Published online on: 11 August 2026

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Retraction Open Access

[Retracted] Resistant starch prevents tumorigenesis of dimethylhydrazine‑induced colon tumors via regulation of an ER stress‑mediated mitochondrial apoptosis pathway  

Qiuyu Wang, Peng Wang, Zhigang Xiao
Article Number: 281
Published online on: 10 August 2026

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Review Open Access

XBP1 signaling from tumor metabolic stress to myeloid driven immunotherapy resistance (Review)

Ziwei Chen, Jiaqi Wu, Wenxi Liu, Jie Tan, Xiaochun Peng, Yanhua Zhang, Gai Liang
Article Number: 280
Published online on: 05 August 2026

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Review Open Access

Decoding miRNA‑146a: Mechanisms of action in cardiovascular diseases and endocrine metabolic disorders (Review)

Xiu Yang, Pengcheng Li, Hao Zhao
Article Number: 279
Published online on: 05 August 2026

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Review Open Access

Contribution of p38 MAPK in liver fibrosis: An overview of mechanisms, signaling pathways, and therapeutic targets (Review)

Xueqin Yang, Huarong Li, Hao Ye, Ting Wu, Fangyun Xu, Chao Hu, Chunlei Yu, Pian Ye
Article Number: 278
Published online on: 05 August 2026

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Correction Open Access

[Corrigendum] Peroxisome proliferator‑activated receptor α regulates acesulfame‑K‑induced NAFLD via hepatic PLCβ: Foe and friend

Peng-Yao Lin, Jia-Rong Xie, Tian-Chen Qian, Shi-Song Wang, Si-Yi Yu, Wen-Bo Shi, Ying Wang, Lu-Ze Cen, Qing-Jing Zhu, Yi-Yang Zheng, Hui Gao, Rong Fang, Zhao-Xia Xia, Ai-Ming Liu, Lei Xu
Article Number: 277
Published online on: 05 August 2026

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Review Open Access

Multi‑omics insights into uveitis: From mechanisms to precision medicine (Review)

Chengzhi Liu, Qiong Wu, Mingzhen Yuan, Mingyue Liu, Xinyu Wang, Jiaqi Shen, Xusheng Cao
Article Number: 276
Published online on: 03 August 2026

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Retraction Open Access

[Retracted] Effects of miRNA‑455 on cardiac hypertrophy induced by pressure overload

Chuntao Wu, Shimin Dong, Yongjun Li
Article Number: 275
Published online on: 03 August 2026

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Article Open Access

Energy stress activates AMPK to suppress ferroptosis in neurodegenerative proteinopathies

Yuanyuan Yong, Yuxin Hu, Qian Feng, Xiaogang Zhou, Lu Yu, Dalian Qin, Jianing Mi, Jianming Wu, Jianxin Liu, Anguo Wu
Article Number: 274
Published online on: 31 July 2026

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Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Review Open Access

Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Review Open Access

Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Review Open Access

Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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Article Open Access

circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Review Open Access

Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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Journal Cover
November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Research progress on BTG2 in non‑tumor diseases (Review)

Shuling Li, Xiaomei Liu, Zheng Zhang, Ling Yang, Yuxuan Li, Qiongdan Hu
Article Number: 299
Published online on: 28 August 2026

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Review Open Access

Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Xincheng Feng, Jue Zhang, Qinghong Ma, Chao Sun
Article Number: 298
Published online on: 27 August 2026

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Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Review Open Access

Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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