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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
April 2005 Volume 15 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Relevance of nuclear localization and functions of RNA helicase A

Hidetoshi Fujita, Takayuki Ohshima, Takayuki Oishi, Satoko Aratani, Ryouji Fujii, Akiyoshi Fukamizu, Toshihiro Nakajima
Pages: 555-560
Published online on: 01 April 2005

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Article

Evolution of interleukin-18 binding proteins and interleukin-1 receptor, type II proteins

Makoto Watanabe, Naohisa Goto, Yuko Watanabe, Seiji Nishiguchi, Kazunori Shimada, Teruo Yasunga, Hiromichi Yamanishi
Pages: 561-566
Published online on: 01 April 2005

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Article

Adrenomedullin, ANP and BNP are colocalized in a subset of endocrine cells in the rat heart

Anna S. Belloni, Diego Guidolin, Roberta Salmaso, Sergio Bova, Gian Paolo Rossi, Gastone G. Nussdorfer
Pages: 567-571
Published online on: 01 April 2005

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Article

Immunolocalization of platelet glycoprotein IIb/IIIa and P-selectin, and neutrophil - platelet interaction in human coronary unstable plaques

Takeshi Ikuta, Takahiko Naruko, Yoshihiro Ikura, Masahiko Ohsawa, Hiroko Fukushima, Nobuyuki Shirai, Akira Itoh, Kazuo Haze, Shoichi Ehara, Yasuyuki Sasaki, Toshihiko Shibata, Shigefumi Suehiro, Makiko Ueda
Pages: 573-577
Published online on: 01 April 2005

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Article

Human adrenomedullin gene silencing by short interfering RNAs: A preliminary study

Giovanna Albertin, Gianni Carraro, Gastone G. Nussdorfer
Pages: 579-583
Published online on: 01 April 2005

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Article

Down-regulation of DMBT1 gene expression in human oral squamous cell carcinoma

Massao Alberto Imai, Tetsuhiro Moriya, Fabiana Lica Imai, Masashi Shiiba, Hiroki Bukawa, Hidetaka Yokoe, Katsuhiro Uzawa, Hideki Tanzawa
Pages: 585-589
Published online on: 01 April 2005

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Article

Plasma level and tissue expression of angiogenic factors in patients with hereditary hemorrhagic telangiectasia

Haneen Sadick, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel
Pages: 591-596
Published online on: 01 April 2005

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Article

Status of reduced expression and hypermethylation of the APC tumor suppressor gene in human oral squamous cell carcinoma

Hisako Uesugi, Katsuhiro Uzawa, Kenshi Kawasaki, Ken Shimada, Tetsuhiro Moriya, Akio Tada, Masashi Shiiba, Hideki Tanzawa
Pages: 597-602
Published online on: 01 April 2005

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Article

Protein and mRNA expression levels of VEGF-A and TGF-β1 in different types of human coronary atherosclerotic lesions

Dimitrios Panutsopulos, Efstathios Papalambros, Fragiska Sigala, Alexandros Zafiropoulos, Dimitrios L. Arvanitis, Demetrios A. Spandidos
Pages: 603-610
Published online on: 01 April 2005

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Article

Expression of the gene for hematopoietic cell specific protein is not restricted to cells of hematopoietic origin

Ulrike Fischer, Armin Michel, Eckart U. Meese
Pages: 611-615
Published online on: 01 April 2005

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Article

Amplification and functional characterization of MUC1 promoter and gene-virotherapy via a targeting adenoviral vector expressing hSSTR2 gene in MUC1-positive Panc-1 pancreatic cancer cells in vitro

Limo Chen, Qiang Liu, Renyi Qin, Huangying Le, Ruijuan Xia, Weihua Li, Manoj Kumar
Pages: 617-626
Published online on: 01 April 2005

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Article

Polymorphisms and mutations of the folate receptor-alpha gene and risk of gastric cancer in a Chinese population

Gui Zhang, Qing-Ying Zhang, Xiao-Ping Miao, Dong-Xin Lin, You-Yong Lu
Pages: 627-632
Published online on: 01 April 2005

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Article

Extracellular matrix activity and caveolae events contribute to cell surface receptor activation that leads to MAP kinase activation in response to UV irradiation in cultured human keratinocytes

Qun Wang, Alicia Turlington, Stephan Heo, Andrea Blanco, Jian Tian, Zijia Xie, Bingfang Yan, Yinsheng Wan
Pages: 633-640
Published online on: 01 April 2005

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Article

Modulation of the CXC-chemokine expression profile on tumor cells by the immunosuppressive drug mycophenolate mofetil

Tobias Engl, Borna Relja, Iyad Natsheh, Jasmina Makarevic, Iris Müller, Wolf-Dietrich Beecken, Dietger Jonas, Roman A. Blaheta
Pages: 641-647
Published online on: 01 April 2005

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Article

Heat shock protein 90 is required for increased DNA binding activity of activator protein-1, a heterodimer of Fos/JunD, in rheumatoid synovial cells under inflammatory stimuli

Miki Murata, Yasushi Miura, Akira Hashiramoto, Hitomi Kitamura, Hiroki Kawasaki, Kazuko Shiozawa, Shinichi Yoshiya, Hisamitsu Baba, Kazuo Chihara, Shunichi Shiozawa
Pages: 649-653
Published online on: 01 April 2005

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Article

Clinical significance of abnormal lipoprotein patterns in liver diseases

Kinue Ooi, Katsuya Shiraki, Yuko Sakurai, Yoshitska Morishita, Tsutomu Nobori
Pages: 655-660
Published online on: 01 April 2005

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Article

Analysis of the apolipoprotein(a) size polymorphism in patients with systemic lupus erythematosus

Emmanouil Peros, Diego Geroldi, Serena Bugatti, Roberto Caporali, Paola Rossi, Carlomaurizio Montecucco, Angela D'Angelo, Enzo Emanuele
Pages: 661-665
Published online on: 01 April 2005

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Article

Involvement of NF-κB and mitochondrial pathways in docetaxel-induced apoptosis of human oral squamous cell carcinoma

Takahiro Taniguchi, Masato Takahashi, Fumiaki Shinohara, Tomonori Sato, Seishi Echigo, Hidemi Rikiishi
Pages: 667-673
Published online on: 01 April 2005

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Article

β-Cryptoxanthin stimulates cell proliferation and transcriptional activity in osteoblastic MC3T3-E1 cells

Satoshi Uchiyama, Masayoshi Yamaguchi
Pages: 675-681
Published online on: 01 April 2005

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Article

Expression of hTERT mRNA in a mortal liver cell line during S phase without detectable telomerase activity

Kumi Nagao, Junko H. Ohyashiki, Kazuma Ohyashiki, Keiko Tabata, Kenji Takai, Kazuhisa Kameyama, Soichi Kitano, Katsumi Kawano, Nozomu Hibi, Taichi Kanamaru, Hisashi Hisatomi
Pages: 683-688
Published online on: 01 April 2005

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Article

Changes in gene expression level for defense system enzymes against oxidative stress and glutathione level in rat administered paraquat

Masafumi Tomita, Hironobu Katsuyama, Toshiko Okuyama, Kazuo Hidaka, Yohsuke Minatogawa
Pages: 689-693
Published online on: 01 April 2005

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Article

Effects of middle molecular weight fucoidans on in vitro and ex vivo angiogenesis of endothelial cells

Kiminori Matsubara, Changhu Xue, Xue Zhao, Masaharu Mori, Tatsuya Sugawara, Takashi Hirata
Pages: 695-699
Published online on: 01 April 2005

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Review

Vitamin D in normal and pathological parathyroid glands: New prospects for treating hyperparathyroidism (Review)

Pamela Correa Buchwald, Gunnar Westin, Göran Åkerström
Pages: 701-706
Published online on: 01 April 2005

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Article

Ghrelin, peptide YY and their receptors: Gene expression in brain from subjects with and without Prader-Willi syndrome

Zohreh Talebizadeh, Nataliya Kibiryeva, Douglas C. Bittel, Merlin G. Butler
Pages: 707-711
Published online on: 01 April 2005

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Article

Identification of active siRNAs against IGF-IR of porcine coronary smooth muscle cells in a heterologous cell line

Laura Poliseno, Monica Evangelista, Fernanda Ricci, Alessandra Bonotti, Monica Nannipieri, Giuseppe Rainaldi
Pages: 713-718
Published online on: 01 April 2005

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Article

Identification and characterization of a novel human nephronectin gene in silico

Jeffrey T.-J. Huang, Vivian Lee
Pages: 719-724
Published online on: 01 April 2005

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Article

Phosphorylated and hypoacetylated mutant p53 enhances cisplatin-induced apoptosis through caspase-9 pathway in the absence of transcriptional activation or translation

Ming-Derg Lai, Wan-Chi Lin, Yih-Min Sun, Fu-Lin Chang
Pages: 725-734
Published online on: 01 April 2005

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Article

Evaluation of proteasome-inhibitory and apoptosis-inducing potencies of novel (-)-EGCG analogs and their prodrugs

Kristin R. Landis-Piwowar, Deborah J. Kuhn, Sheng Biao Wan, Di Chen, Tak Hang Chan, Q. Ping Dou
Pages: 735-742
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt3 - Wnt9b gene cluster

Masaru Katoh
Pages: 743-747
Published online on: 01 April 2005

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Article

Comparative genomics on Wnt5a and Wnt5b genes

Masuko Katoh, Masaru Katoh
Pages: 749-753
Published online on: 01 April 2005

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Journal Cover
June-2026 Volume 57 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression

Hang Guo, Yaoji Li, Chengyan Jin, Xiao Qi, Jincheng Wang, Baofeng Li, Chunguang Wang
Article Number: 168
Published online on: 28 April 2026

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Retraction Open Access

[Retracted] Metformin‑induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16

Biao Hao, Yan Xiao, Fang Song, Xiangshu Long, Jing Huang, Maobo Tian, Shiyan Deng, Qiang Wu
Article Number: 167
Published online on: 22 April 2026

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Review Open Access

Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review)

Ke Wan, Miao Wang, Qingqing Xia, Hui Fang, Ying Chen, Tongsheng Zhou, Xue Yang, Lu Wang, Jianwen Ye, Han Shu, Xiao-Feng Li, Jun Li
Article Number: 166
Published online on: 22 April 2026

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Retraction Open Access

[Retracted] Puerarin attenuates glucocorticoid‑induced apoptosis of hFOB1.19 cells through the JNK‑ and Akt‑mediated mitochondrial apoptotic pathways

Dongdong Yu, Shuai Mu, Danyang Zhao, Guangbin Wang, Zhiguang Chen, Hongfei Ren, Qin Fu
Article Number: 165
Published online on: 20 April 2026

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Review Open Access

High‑altitude polycythemia: Unveiling the molecular landscape beyond erythropoietin (Review)

Haiyan Li, Hongjuan Zhang, Hujun Zhang, Yujie Li, Yigang He, Jia Luan
Article Number: 164
Published online on: 17 April 2026

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Review

Mechanistic roles of interleukin‑18 in colonic immunity across infection, inflammatory bowel disease, and colorectal cancer (Review)

Jingwen Zhang, Lili Bao, Xia Li, Jiaxi Li, Jiaxian Cui, Lu Qiao, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Tuya Bai, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 163
Published online on: 17 April 2026

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Article Open Access

IDH2 lactylation regulates mitochondrial dysfunction injury induced by myocardial ischemia‑reperfusion via the AMPK signaling pathway

Changsen Wang, Siman Shen, Suyun Chen, Jinda Lin, Simeng Li, Jianning Chen, Shuyun Cai, Xiaodong Yuan, Ziqiang Yang, Kun Ding, Li Xu, Liangqing Zhang
Article Number: 162
Published online on: 17 April 2026

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Review Open Access

Context‑dependent duality of the apelin/elabela‑APJ system in diabetes and its complications (Review)

Zhenyuan Han, Jiale Zhang, Min Shi, Juan Chen, Anni Li, Yuxuan Ye, Hong Zhang
Article Number: 161
Published online on: 17 April 2026

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Review Open Access

Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)

Taimin Zhang, Xizhe Zhang, Yaru Xie, Yue Liu, Siyu Xia, Xiaodie Yin, Tian Li, Libin Liao
Article Number: 160
Published online on: 16 April 2026

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Retraction Open Access

[Retracted] Quercetin promotes the apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1

Fang Pan, Lihua Zhu, Haozhe Lv, Chunpeng Pei
Article Number: 159
Published online on: 15 April 2026

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Article Open Access

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells

Yeyang Chen, Hua Wu, Xiangjian Wu, Likun Che, Xiaoyan Fu, Ruihan Qi, Dan Jia, Minfang Li, Wei Xie, Wenxiang Zhu
Article Number: 158
Published online on: 15 April 2026

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Review Open Access

ETS‑1/ETS‑2 transcription factors in CVD (Review)

Shasha Yang, Jing Zhang, Ying Yang, Yunbo Lv, Jian Yang, Huibo Wang
Article Number: 157
Published online on: 15 April 2026

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Review Open Access

RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review)

Shuhui Liu, Zhiyuan Ma, Bei Ji, Jiaxing Zhu, Shun Yao, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 156
Published online on: 14 April 2026

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Retraction Open Access

[Retracted] Role of miR‑146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro  

Lei Jin, Jian Zhao, Wensen Jing, Shiju Yan, Xin Wang, Chun Xiao, Baoan Ma
Article Number: 155
Published online on: 07 April 2026

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A tale of dual role: HECT‑type E3 ubiquitin ligase mechanisms in liver diseases (Review)

Tongxi Li, Hao Chen, Peng Zhao, Chuanzheng Yin, Zifang Song
Article Number: 154
Published online on: 07 April 2026

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Correction Open Access

[Corrigendum] Macrophage‑derived foam cells impair endothelial barrier function by inducing endothelial‑mesenchymal transition via CCL‑4 

Ying Yang, Nian-Sang Luo, Ru Ying, Yong Xie, Jia-Yuan Chen, Xiao-Qiao Wang, Zhen-Jie Gu, Jing-Ting Mai, Wen-Hao Liu, Mao-Xiong Wu, Zhi-Teng Chen, Yong-Biao Fang, Hai-Feng Zhang, Zhi-Yi Zuo, Jing-Feng Wang, Yang-Xin Chen
Article Number: 153
Published online on: 03 April 2026

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Macrophage metabolism reprogramming in sepsis: Pathogenesis and therapeutic implications (Review)

Tong Zhao, Wenzhe Zhang, Zixuan Ren, Xiujing Feng
Article Number: 152
Published online on: 03 April 2026

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Article Open Access

Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway

Jiale Li, Yufei Qu, Wenge Zhang, Zexu Yang, Yangdong Zeng, Jisheng Xu, Kuncen Xie, Qi Liu
Article Number: 151
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation

Keng Wu, Wenming Xu, Qiong You, Runmin Guo, Jianqiang Feng, Changran Zhang, Wen Wu
Article Number: 150
Published online on: 01 April 2026

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Review Open Access

Animal models accurately representing acute liver failure (Review)

Sang Luo, Fang Wu, Yiran Jin, Xiaofen Huang, Dan Liu, Bingren Tian
Article Number: 149
Published online on: 01 April 2026

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Correction Open Access

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism 

Zhirong Zhang, Weiji Yang, Rongbiao Ying, Ying Shi, Huifang Jiang, Danli Cai, Jing Kuang, Ruhui Yang, Lingcong Wang
Article Number: 148
Published online on: 31 March 2026

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Review Open Access

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

Jing Mao, Mandi Luo, Lei Ruan, Cuntai Zhang
Article Number: 147
Published online on: 31 March 2026

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Review Open Access

Role of aging‑related cytokines in neurodegenerative disease (Review)

Xinke Dai, Xinran Rao, Yuandi Wang, Weijiang Zhao
Article Number: 146
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Peng Xu, Xuelei Tao, Chengjin Zhao, Qingfeng Huang, Hao Chang, Na Ban, Yuanqi Bei, Xiaojie Xia, Chaoyan Shen, Kun Wang, Li Xu, Peizhang Wu, Jianbing Ren, Donglin Wang
Article Number: 145
Published online on: 30 March 2026

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Review Open Access

Role of itaconate in intestinal disease (Review)

Xin Li, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Bingqi Yang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 144
Published online on: 27 March 2026

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Review Open Access

Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review)

Yuanyuan Xiao, Niansong Wang, Dingkun Gui, Youhua Xu
Article Number: 143
Published online on: 27 March 2026

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Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Yanming Wei, Kun Zhou, Yuerui Su, Zhihua Luan, Pengcheng Li, Yinxia Chang, Bo Han, Huifang Li, Yuanbiao Qiao, Jinhong Ren
Article Number: 142
Published online on: 26 March 2026

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Article Open Access

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
Article Number: 141
Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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July-2026 Volume 58 Issue 1

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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