Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions

  • Authors:
    • Jacek Kubica
    • Marek Kozinski
    • Anna Krzewina-Kowalska
    • Magdalena Zbikowska-Gotz
    • Grazyna Dymek
    • Adam Sukiennik
    • Radoslaw Piasecki
    • Maria Bogdan
    • Grzegorz Grzesk
    • Maciej Chojnicki
    • Andrzej Dziedziczko
    • Grazyna Sypniewska
  • View Affiliations

  • Published online on: July 1, 2005     https://doi.org/10.3892/ijmm.16.1.173
  • Pages: 173-180
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Abstract

To assess the value of serial C-reactive protein (CRP), serum amyloid A (SAA), tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) evaluation in the risk stratification in patients undergoing percutaneous coronary intervention. The study was designed as a prospective cohort trial with a 1-year follow-up. Eighty patients (70 with stable angina, 10 with unstable angina) were enrolled. Blood samples were collected before the procedure and after 6 and 24 h, and 1 month. Clinical follow-up visits were performed (*with exercise test) 7 days* and 1*, 3, 6* and 12 months after the procedure. Any symptoms of restenosis were verified angiographically. Multivariate logistic regression analysis identified increased preprocedural TNF-α and CRP levels and elevated CRP concentrations evaluated 24 h after the procedure as significant predictors of both clinical restenosis and major adverse cardiac events (MACE), while high SAA values at 24 h accurately predicted clinical restenosis. Patients, who were in the highest tertile of, either, baseline TNF-α and/or baseline CRP/CRP at 24 h, were more prone to develop restenosis and MACE than stratified only on the basis of a single marker. Our data indicate that combined analysis of CRP and TNF-α might be an effective approach to the clinical restenosis and MACE prediction. Additionally, long-term outcome is markedly influenced by the periprocedural activation of inflammation.

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July 2005
Volume 16 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Kubica J, Kozinski M, Krzewina-Kowalska A, Zbikowska-Gotz M, Dymek G, Sukiennik A, Piasecki R, Bogdan M, Grzesk G, Chojnicki M, Chojnicki M, et al: Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions. Int J Mol Med 16: 173-180, 2005.
APA
Kubica, J., Kozinski, M., Krzewina-Kowalska, A., Zbikowska-Gotz, M., Dymek, G., Sukiennik, A. ... Sypniewska, G. (2005). Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions. International Journal of Molecular Medicine, 16, 173-180. https://doi.org/10.3892/ijmm.16.1.173
MLA
Kubica, J., Kozinski, M., Krzewina-Kowalska, A., Zbikowska-Gotz, M., Dymek, G., Sukiennik, A., Piasecki, R., Bogdan, M., Grzesk, G., Chojnicki, M., Dziedziczko, A., Sypniewska, G."Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions". International Journal of Molecular Medicine 16.1 (2005): 173-180.
Chicago
Kubica, J., Kozinski, M., Krzewina-Kowalska, A., Zbikowska-Gotz, M., Dymek, G., Sukiennik, A., Piasecki, R., Bogdan, M., Grzesk, G., Chojnicki, M., Dziedziczko, A., Sypniewska, G."Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions". International Journal of Molecular Medicine 16, no. 1 (2005): 173-180. https://doi.org/10.3892/ijmm.16.1.173