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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July 2005 Volume 16 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Tight junctions and bladder cancer (Review)

Mark D. Haynes, Tracey A. Martin, Spencer A. Jenkins, Howard G. Kynaston, Philip N. Matthews, Wen G. Jiang
Pages: 3-9
Published online on: 01 July 2005

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Article

Identification of proteins from colorectal cancer tissue by two-dimensional gel electrophoresis and SELDI mass spectrometry

Christian Melle, Dirk Osterloh, Günther Ernst, Bettina Schimmel, Annett Bleul, Ferdinand Von Eggeling
Pages: 11-17
Published online on: 01 July 2005

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Article

Cloning, expression and characterization of human glutathione S-transferase Omega 2

Liu Wang, Jian Xu, Chaoneng Ji, Shaohua Gu, You Lv, Shi Li, Yiren Xu, Yi Xie, Yumin Mao
Pages: 19-27
Published online on: 01 July 2005

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Article

Drug-induced toxic epidermal necrolysis and pancytopenia: A puzzling association

Philippe Paquet, Eric Jacob, Jean Pirson, Gerald E. Pierard
Pages: 29-33
Published online on: 01 July 2005

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Article

Differential expression and function of beacon in the rat adrenal cortex and medulla

Marcin Rucinski, Paola G. Andreis, Agnieszka Ziolkowska, Gastone G. Nussdorfer, Ludwik K. Malendowicz
Pages: 35-40
Published online on: 01 July 2005

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Article

Regulatory effects of emodin on NF-κB activation and inflammatory cytokine expression in RAW 264.7 macrophages

Hai-Long Li, Hai-Long Chen, Hong Li, Kai-Li Zhang, Xiao-Yan Chen, Xiao-Wei Wang, Qing-You Kong, Jia Liu
Pages: 41-47
Published online on: 01 July 2005

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Article

Direct effect of plasma permeability factors from patients with idiopatic FSGS on nephrin and podocin expression in human podocytes

Sophie Doublier, Luca Musante, Enrico Lupia, Giovanni Candiano, Tiziana Spatola, Gianluca Caridi, Cristina Zennaro, Michele Carraro, Gian Marco Ghiggeri, Giovanni Camussi
Pages: 49-58
Published online on: 01 July 2005

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Article

Remote delivery and expression of soluble type II TGF-β receptor in muscle prevents hepatic fibrosis in rats

Makoto Nakamuta, Shusuke Morizono, Satoru Tsuruta, Motoyuki Kohjima, Kazuhiro Kotoh, Munechika Enjoji
Pages: 59-64
Published online on: 01 July 2005

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Article

Generation and characterization of iBREC: Novel hTERT-immortalized bovine retinal endothelial cells

Heidrun Deissler, Helmut Deissler, Gerhard K. Lang, Gabriele E. Lang
Pages: 65-70
Published online on: 01 July 2005

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Article

Cytokine-induced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats

Taiji Yamaguchi, Norimasa Yoshida, Naoya Tomatsuri, Ryuretsu Takayama, Kazuhiro Katada, Tomohisa Takagi, Hiroshi Ichikawa, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa
Pages: 71-77
Published online on: 01 July 2005

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Article

Frequent apoptosis in placental villi from pregnancies complicated with intrauterine growth restriction and without maternal symptoms

Hisae Endo, Aikou Okamoto, Kyosuke Yamada, Takashi Nikaido, Tadao Tanaka
Pages: 79-84
Published online on: 01 July 2005

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Article

Aberrations of the CHK2 gene are rare in pediatric solid tumors

Yu Yan Chen, Junko Takita, Kiyoshi Tanaka, Kohmei Ida, Katsuyoshi Koh, Takashi Igarashi, Ryoji Hanada, Akira Kikuchi, Yukichi Tanaka, Yasunori Toyoda, Yasuhide Hayashi
Pages: 85-91
Published online on: 01 July 2005

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Article

Fine deletional mapping of chromosome 4q22-35 region in oral cancer

Yasuo Shinno, Esra Gunduz, Mehmet Gunduz, Hitoshi Nagatsuka, Hidetsugu Tsujigiwa, Beyhan Cengiz, You-Jin Lee, Ryo Tamamura, Mamoru Ouchida, Kunihiro Fukushima, Kenji Shimizu, Noriyuki Nagai
Pages: 93-98
Published online on: 01 July 2005

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Article

The anti-inflammatory effects of 2 Hz electroacupuncture with different intensities on acute carrageenan-induced inflammation in the rat paw

Jun-Hyuk Lee, Yung-Hyun Choi, Byung-Tae Choi
Pages: 99-102
Published online on: 01 July 2005

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Article

Roles of His9 (P2 subsite) and His13 (P3' subsite) in angiotensinogen for catalytic reaction of renin

A.H.M. Nurun Nabi, Mohammad Nasir Uddin, Tsutomu Nakagawa, Takenori Orihashi, Akio Ebihara, Atsushi Iwasawa, Yukio Nakamura, Fumiaki Suzuki
Pages: 103-107
Published online on: 01 July 2005

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Article

Causal relationship between hepatitis C virus core and the development of type 2 diabetes mellitus in a hepatitis C virus hyperendemic area: A pilot study

Takumi Kawaguchi, Yumiko Nagao, Kazuo Tanaka, Tatsuya Ide, Masaru Harada, Ryukichi Kumashiro, Michio Sata
Pages: 109-114
Published online on: 01 July 2005

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Article

Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner

Kazunori Yukawa, Tetsuji Tanaka, Tao Bai, Takashi Ueyama, Kyoko Owada-Makabe, Yuji Tsubota, Masanobu Maeda, Kazuhiro Suzuki, Hitoshi Kikutani, Atsushi Kumanogoh
Pages: 115-118
Published online on: 01 July 2005

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Article

Evidence of dual function of macrophage migration inhibitory factor relevant to tumor progression and regression

Tsuyoshi Fukushima, Jun Nishihira, Takashi Yoshiki, Kazuya Iwabuchi, Chikako Iwabuchi, Yoshiki Yamasaki, Masao Kondo, Bailong Sun, Yuji Sato, Satoru Todo
Pages: 119-126
Published online on: 01 July 2005

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Review

Two secretory immune systems (mucosal and barrier) in human intrauterine development, normal and pathological (Review)

Itshak Zusman, Pavel Gurevich, Herzl Ben-Hur
Pages: 127-133
Published online on: 01 July 2005

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Article

CGH analysis of familial non-BRCA1/BRCA2 breast tumors and mutation screening of a candidate locus on chromosome 17q11.2-12

Paula Maguire, Kerstin Holmberg, Maria Kost-Alimova, Stefan Imreh, Lambert Skoog, Annika Lindblom
Pages: 135-141
Published online on: 01 July 2005

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Article

Kinetic fluorescence rt-pcr is highly sensitive for detection of germ-cell-tumor-specific transcripts in peripheral blood

M. Schrader, H. Krause, S. Weikert, B. Straub, M. Schostak, F. Christoph, K. Miller
Pages: 143-147
Published online on: 01 July 2005

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Article

The influence of lidocaine and verapamil on the proliferation, CD44 expression and apoptosis behavior of human chondrocytes

D. Wohlrab, M. Vocke, T. Klapperstück, W. Hein
Pages: 149-157
Published online on: 01 July 2005

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Article

Vascular endothelial growth factor and basic fibroblast growth factor are released by squamous cell carcinoma cells after irradiation and increase resistance to subsequent irradiation

Jürgen Brieger, Petra Schroeder, Jan Gosepath, Wolf J. Mann
Pages: 159-164
Published online on: 01 July 2005

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Article

Antibodies raised against N'-terminal Pseudomonas aeruginosa flagellin prevent mortality in lethal murine models of infection

Lewis F. Neville, Yoav Barnea, Orly Hammer-Munz, Eyal Gur, Boris Kuzmenko, Hamutal Kahel-Raifer, Rachel Eren, Adi Elkeles, Kanneganti G.K. Murthy, Csaba Szabó, Andrew L. Salzman, Shlomo Dagan, Yehuda Carmeli, Shiri Navon-Venezia
Pages: 165-171
Published online on: 01 July 2005

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Article

Combined periprocedural evaluation of CRP and TNF-α enhances the prediction of clinical restenosis and major adverse cardiac events in patients undergoing percutaneous coronary interventions

Jacek Kubica, Marek Kozinski, Anna Krzewina-Kowalska, Magdalena Zbikowska-Gotz, Grazyna Dymek, Adam Sukiennik, Radoslaw Piasecki, Maria Bogdan, Grzegorz Grzesk, Maciej Chojnicki, Andrzej Dziedziczko, Grazyna Sypniewska
Pages: 173-180
Published online on: 01 July 2005

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Article

Comparative genomics on Shisa orthologs

Yuriko Katoh, Masaru Katoh
Pages: 181-185
Published online on: 01 July 2005

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Journal Cover
March-2026 Volume 57 Issue 3

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Ginkgolide C alleviates atherosclerosis via activating Nrf2 to inhibit ROS‑dependent NLRP3 inflammasome activation

Rui Zhang
Article Number: 75
Published online on: 27 January 2026

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Review Open Access

MicroRNA‑microbiome cross‑kingdom networks drive inflammatory bowel disease through dynamic regulatory ecosystems (Review)

Liping Liang, Xiaoyan Liu, Bang Li, Huyi Lei, Zibo Tang, Shijie Mai, Chenghai Yang, Yongjian Zhou, Shaoheng Zhang, Le Liu
Article Number: 74
Published online on: 27 January 2026

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Review Open Access

Mechanistic insights into pancreatic cancer progression from circadian rhythm disruption and gut microbiota dysbiosis (Review)

Yang Liu, Yongfeng Li, Heng Ma, Shichang Deng, Chao Cheng
Article Number: 73
Published online on: 26 January 2026

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Retraction Open Access

[Retracted] miR‑124‑3p inhibits the viability and motility of glioblastoma multiforme by targeting RhoG  

Shan Cai, Chao-Jia Shi, Jian-Xiang Lu, Yan-Pei Wang, Tian Yuan, Xiang-Peng Wang
Article Number: 72
Published online on: 26 January 2026

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Review Open Access

Natural products as multi‑target therapies for sepsis‑induced myocardial dysfunction (Review)

Fei Tang, Dong Liu, Shi-Chao Zhu, Hui-Min Zhou, Xue-Wen Qiu
Article Number: 71
Published online on: 22 January 2026

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Review Open Access

MTHFR‑folate axis as a modulator of the epigenetic landscape in autoimmune diseases (Review)

Pablo Michael Navarro‑Rodríguez, Ramón Francisco Bajeca‑Serrano, Francisco Javier Turrubiates‑Hernández, Hazael Ramiro Ceja‑Gálvez, Jorge Hernández‑Bello, Cristian Oswaldo Hernández‑Ramírez, Saúl Ramírez‑de Los Santos, José Francisco Muñoz‑Valle
Article Number: 70
Published online on: 22 January 2026

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Article Open Access

Natural compound 5,7,8‑trimethoxyflavone mitigates radiation‑induced lung injury by suppressing EMT and PI3K/Akt pathway

Cui-Cui Gong, Hua-Kang Li, Yuan-Zhen Mi, Jun-Yang Chen, Zeng-Yi Fang, Shun-Lian Fu, Li Quan, Bing Lin, Jin-Yi Lang, Qiu Chen, Ke Xu, Mei-Hua Chen
Article Number: 69
Published online on: 21 January 2026

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Review Open Access

Epigenetic dysregulation of B‑cells in autoimmune diseases and lymphomas (Review)

Yuxing Li, Yujiao Gong, Jiaxing Zhao, Rensen Ran
Article Number: 68
Published online on: 21 January 2026

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Review Open Access

Research progress on the effects of macrophage‑derived exosomes on muscle factors IGF‑1 and FGF‑2 mediating musculoskeletal crosstalk molecular signaling pathway on bone metabolism (Review)

Ruo-Mei Cui, Mai Zheng, Jian-Bin Hong, Zheng-Xiang Wang, Yu-Fang Cun, Shu-Ji Gao, Yan-Lin Zhu, Zi-Bin Yang, Ming-Wei Liu
Article Number: 67
Published online on: 21 January 2026

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Expression of Concern Open Access

[Expression of Concern] Long non‑coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β‑catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Article Number: 66
Published online on: 21 January 2026

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Review Open Access

Mangiferin in human disease: Multifaceted mechanisms and applications (Review)

Yaling Dai, Qiuling Huang, Mengquan Tan, Zhifu Wang, Cai Jiang, Zheng Liu, Shenghang Zhang, Siyuan Song
Article Number: 65
Published online on: 21 January 2026

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Article

Deciphering the CAF‑LCN2 axis: Key to overcoming anti‑PD‑L1 immunotherapy resistance in lung cancer

Dan Xiao, Jing Yang, Jianying Zhou, Zhenzhen Hu, Ting Zhang
Article Number: 64
Published online on: 19 January 2026

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Retraction Open Access

[Retracted] DDAH2 alleviates myocardial fibrosis in diabetic cardiomyopathy through activation of the DDAH/ADMA/NOS/NO pathway in rats

Zhen-Dong Zhu, Ji-Ming Ye, Xue-Mei Fu, Xue-Chang Wang, Ji-Yun Ye, Xin-Ran Wu, Peng Hua, Yu-Qiong Liao, Wei Xuan, Jin-Lan Duan, Wei-Yuan Li, Hui Fu, Zhong-Hua Xia, Xuan Zhang
Article Number: 63
Published online on: 19 January 2026

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Review Open Access

Beyond hepatic stellate cell heterogeneity: Resolving fibrosis, restoring regeneration (Review)

Chang Gao, Guiqing Chen, Hongyan Jia, Hong Zhu, Yun Cai, Dakai Yang, Kai Zhao
Article Number: 62
Published online on: 14 January 2026

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Correction Open Access

[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 61
Published online on: 14 January 2026

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Review Open Access

Harnessing MSC‑derived exosomes to modulate the pathophysiology of ASD: Recent advances and therapeutic implications (Review)

Zhaojian Sun, Nouman Amjad, Majid Muhammad, Zhiyuan Li
Article Number: 60
Published online on: 13 January 2026

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Retraction Open Access

[Retracted] Mechanism of cell death induced by silica nanoparticles in hepatocyte cells is by apoptosis

Ye Yang, Xinjing Du, Qiang Wang, Jianwei Liu, Enguo Zhang, Linlin Sai, Cheng Peng, Martin F. Lavin, Abrey Jie Yeo, Xu Yang, Hua Shao, Zhongjun Du
Article Number: 59
Published online on: 12 January 2026

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Review Open Access

ZG16B: A key regulator of tumor progression and immune microenvironment modulation in cancer (Review)

Xing-Ming Chen, Yu-Bo Liang, Jin-Xiang Zuo, Zi-Sheng Yang, Le-Yu Zhang, Xin-Yu Zhang, Ping Wan, Yang Ke
Article Number: 58
Published online on: 09 January 2026

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Retraction Open Access

[Retracted] Silica nanoparticles induce cardiomyocyte apoptosis via the mitochondrial pathway in rats following intratracheal instillation

Zhongjun Du, Shangya Chen, Guanqun Cui, Ye Yang, Enguo Zhang, Qiang Wang, Martin F. Lavin, Abrey J. Yeo, Cunxiang Bo, Yu Zhang, Chao Li, Xiaoshan Liu, Xu Yang, Cheng Peng, Hua Shao
Article Number: 57
Published online on: 05 January 2026

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Review Open Access

Role of cuproptosis in digestive system tumors (Review)

Li Zhang, Yongpeng Cheng, Lulu Tang, Jiaxing Zhu, Biguang Tuo
Article Number: 56
Published online on: 02 January 2026

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Review Open Access

Environmental exposure to air pollution and climate: Intersecting the impact on ear and nose health and chemosensory function (Review)

Yu-Chen Zhang, Lei Zhang, Ping-Ting Zhou, Zi-Hui Xie, Wen-Jie Zhang, Min Fan, Yan-Xun Han, Ye-Hai Liu, Yu-Chen Liu
Article Number: 55
Published online on: 31 December 2025

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Review Open Access

Role and mechanisms of ferroptosis in cognitive impairment: From molecular pathways to therapeutic targets (Review)

Shenghui Ge, Deyue Kong, Shuyue Fan, Yi Luo, Xiao Yin, Zehua Jin, Wenqing Xia, Jianhua Ma
Article Number: 54
Published online on: 30 December 2025

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Review Open Access

The GPR124‑Wnt‑PPARγ regulatory axis: Molecular mechanisms and therapeutic implications in chronic inflammatory diseases (Review)

Ming-Wang Cui, Si-Yu Tao, Tao Wen, Zhu-Ling Guo
Article Number: 53
Published online on: 30 December 2025

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Review Open Access

Advances in RPGR gene therapy for X‑linked retinitis pigmentosa: From preclinical insights to clinical application (Review)

Yushan Long, Jia Qi, Wenliang Zhang, Huan Qin, Kai Yao
Article Number: 52
Published online on: 30 December 2025

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Journal Cover
April-2026 Volume 57 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Role of vascular smooth muscle cell pathobiology in sepsis‑induced vasoplegia (Review)

Hang Ruan, Xiao-Yan Shen, Shi-Yan Liu, Shu-Sheng Li
Article Number: 87
Published online on: 06 February 2026

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Signalling pathways regulated by FSTL1 in inflammation and potential therapeutic applications (Review)

Changliang Ma, Jingxin Li, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Wencui Li, Zhiqin Deng, Zhe Zhao
Article Number: 86
Published online on: 05 February 2026

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Article Open Access

Hypothermic machine perfusion protects DCD graft liver from ischemia‑reperfusion injury by enhancing macrophage efferocytosis via KLF2‑NLRP3 signaling

Qin Deng, Zhongzhong Liu, Qifa Ye, Jia Liu, Zhihui Fu, Xingjian Zhang, Jun Luo, Zhongshan Lu, Pengpeng Yue, Jiansheng Xiao, Qi Xiao
Article Number: 85
Published online on: 05 February 2026

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Mechanistic advances in exercise‑mediated regulation of autophagy dysfunction in Alzheimer's disease (Review)

Wei Li, Wen-Hong Wang, Yi Song, Xu-Jiong Li, Yan Li, Xia Wang, Ting-Ting Tian, Xiao Huang, Li Zhao
Article Number: 84
Published online on: 04 February 2026

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Correction Open Access

[Corrigendum] p57KIP2‑mediated inhibition of human trophoblast apoptosis and promotion of invasion in vitro

Guo-Qian He, Guang-Yu Liu, Wen-Ming Xu, Hui-Juan Liao, Xing-Hui Liu, Guo-Lin He
Article Number: 83
Published online on: 04 February 2026

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Lipid droplets beyond storage: Cellular metabolic modulator in the diabetic heart (Review)

Yongchun Liang, Xinbiao Fan, Xiaofei Geng, Yunfeng Jia, Wenyu Shang, Xitong Sun, Jun Ge, Guijun Ye, Boyu Zhu, Zheng Zhang, Yuxin Kang, Xiaoyu Shan, Junping Zhang
Article Number: 82
Published online on: 03 February 2026

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Review Open Access

IMP metabolic mechanisms and IMPDH targeting strategies in tumor metabolic reprogramming and therapy (Review)

Hao Zhu, Hao Wang, Xia Li, Weisong Zhang, Yihao Wang, Qingze Tan, Dongxu Ying, Zhan Shi, Jianxiang Song
Article Number: 81
Published online on: 03 February 2026

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Article Open Access

Ebastine targets HER2/HER3 signaling and cancer stem cell traits to overcome trastuzumab resistance in HER2‑positive breast cancer

Eunsun Jung, Ji Young Kim, Dongmi Ko, Juyeon Seo, Sang Yoon Lee, Daeun Lee, Subeen Kim, Minsu Park, Seongjae Kim, Soeun Park, Kyoungmin Lee, Yong Koo Kang, Kee Dal Nam, Yoon-Jae Kim, Jae Hong Seo
Article Number: 80
Published online on: 02 February 2026

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Correction Open Access

[Corrigendum] Inhibition of acid‑sensing ion channel 1a attenuates acid‑induced activation of autophagy via a calcium signaling pathway in articular chondrocytes

Wen-Fan Gao, Ya-Yun Xu, Jin-Fang Ge, Fei-Hu Chen
Article Number: 79
Published online on: 02 February 2026

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Review Open Access

Immunological mechanisms and novel therapeutic strategies for sepsis‑associated acute kidney injury (Review)

Lu Xu, Wei Jiang, Lin Song, Jing Wang, Jiangquan Yu, Ruiqiang Zheng
Article Number: 78
Published online on: 30 January 2026

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Correction Open Access

[Corrigendum] Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Article Number: 77
Published online on: 29 January 2026

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Review Open Access

Spatial metabolomics: A new tool for unravelling the metabolic disorders and heterogeneity in diabetic kidney disease (Review)

Hanfei Li, Yuxi Li, Bo Zhang, Wenhao Cheng, Guowei Ma, Jin Rong, Shiru Duan, Di Feng, Tingting Zhao
Article Number: 76
Published online on: 29 January 2026

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