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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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August 2005 Volume 16 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

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Medicine International

An International Open Access Journal Devoted to General Medicine.

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Article

In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides

  • Authors:
    • Stavroula Baritaki
    • Matthias T. Dittmar
    • Demetrios A. Spandidos
    • Elias Krambovitis

  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Applied Biochemistry, IMBB, FORTH, Vassilika Vouton, P.O. Box 1527, GR 711 10 Heraklion, Crete, Greece
  • Pages: 333-336
    |
    Published online on: August 1, 2005
       https://doi.org/10.3892/ijmm.16.2.333
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Abstract

The aim of the present study was to investigate the inhibitory effect of synthetic peptides derived from the principle neutralizing domain of the V3 loop of the HIV-1 gp120 in the infectivity rates of HIV-1 variants with different tropism. Assessment of the viral infectivity was determined by detection of soluble HIV p24gag antigen in the culture supernatants of PM-1 T cells and primary macrophages after in vitro infection with the R5, Ba-L and X4, NL4.3 variants in the presence or absence of soluble V3-derived synthetic peptides. Our results showed a clear inhibition of Ba-L infectivity in both the PM-1 T cells and primary macrophages. The degree of inhibition was related to the number of basic amino acids in the peptide. The most effective inhibitory peptide, at a concentration of 50 ng/ml, was the one with the highest cationic potential, achieving over 60% inhibition to the PM-1 T cell line and over 90% to primary macrophages. The same peptides did not affect the NL4.3 infectivity. In addition to our previously reported observations on the electrostatic nature of the V3-CCR5 interaction, we show here that V3-like peptides from the more electropositive X4 variants may be useful as effective antagonists and potential infectivity blockers of the R5 variants.

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Copy and paste a formatted citation
Spandidos Publications style
Baritaki S, Dittmar MT, Spandidos DA and Krambovitis E: In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides. Int J Mol Med 16: 333-336, 2005.
APA
Baritaki, S., Dittmar, M.T., Spandidos, D.A., & Krambovitis, E. (2005). In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides. International Journal of Molecular Medicine, 16, 333-336. https://doi.org/10.3892/ijmm.16.2.333
MLA
Baritaki, S., Dittmar, M. T., Spandidos, D. A., Krambovitis, E."In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides". International Journal of Molecular Medicine 16.2 (2005): 333-336.
Chicago
Baritaki, S., Dittmar, M. T., Spandidos, D. A., Krambovitis, E."In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides". International Journal of Molecular Medicine 16, no. 2 (2005): 333-336. https://doi.org/10.3892/ijmm.16.2.333
Copy and paste a formatted citation
x
Spandidos Publications style
Baritaki S, Dittmar MT, Spandidos DA and Krambovitis E: In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides. Int J Mol Med 16: 333-336, 2005.
APA
Baritaki, S., Dittmar, M.T., Spandidos, D.A., & Krambovitis, E. (2005). In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides. International Journal of Molecular Medicine, 16, 333-336. https://doi.org/10.3892/ijmm.16.2.333
MLA
Baritaki, S., Dittmar, M. T., Spandidos, D. A., Krambovitis, E."In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides". International Journal of Molecular Medicine 16.2 (2005): 333-336.
Chicago
Baritaki, S., Dittmar, M. T., Spandidos, D. A., Krambovitis, E."In vitro inhibition of R5 HIV-1 infectivity by X4 V3-derived synthetic peptides". International Journal of Molecular Medicine 16, no. 2 (2005): 333-336. https://doi.org/10.3892/ijmm.16.2.333
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